Carbamazepine
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MedKoo CAT#: 317368

CAS#: 298-46-4

Description: Carbamazepine is a medication used primarily in the treatment of epilepsy and neuropathic pain. For seizures it works as well as phenytoin and valproate. It is not effective for absence seizures or myoclonic seizures. It may be used in schizophrenia along with other medications and as a second line agent in bipolar disorder. It is taken two to four times per day. A controlled release formulation is available for which there is tentative evidence showing less side effects.


Chemical Structure

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Carbamazepine
CAS# 298-46-4

Theoretical Analysis

MedKoo Cat#: 317368
Name: Carbamazepine
CAS#: 298-46-4
Chemical Formula: C15H12N2O
Exact Mass: 236.09496
Molecular Weight: 236.27
Elemental Analysis: C, 76.25; H, 5.12; N, 11.86; O, 6.77

Price and Availability

Size Price Availability Quantity
1.0g USD 120.0 2 Weeks
2.0g USD 190.0 2 Weeks
5.0g USD 250.0 2 Weeks
10.0g USD 450.0 2 Weeks
25.0g USD 650.0 2 Weeks
50.0g USD 950.0 2 Weeks
100.0g USD 1650.0 2 Weeks
200.0g USD 2650.0 2 Weeks
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Synonym: Carbamazepine, Tegretol, Epitol

IUPAC/Chemical Name: benzo[b][1]benzazepine-11-carboxamide

InChi Key: RYLOOVOCHDAWIL-UHFFFAOYSA-N

InChi Code: InChI=1S/C15H12N2O/c16-15(18)12-9-10-5-1-3-7-13(10)17-14-8-4-2-6-11(12)14/h1-9,17H,(H2,16,18)

SMILES Code: O=C(C1=CC2=CC=CC=C2NC3=CC=CC=C13)N

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 236.27 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Xiao Y, Gan L, Wang J, Luo M, Luo H. Vigabatrin versus carbamazepine
monotherapy for epilepsy. Cochrane Database Syst Rev. 2015 Nov 18;11:CD008781.
[Epub ahead of print] Review. PubMed PMID: 26580100.

2: Akyol L, Aslan K, Özgen M, Sayarlioglu M. A rare comorbidity: neurosarcoidosis
and cutaneous sarcoidosis. BMJ Case Rep. 2015 Nov 17;2015. pii: bcr2015211439.
doi: 10.1136/bcr-2015-211439. PubMed PMID: 26578505.

3: Ortiz ÓM. [Drug Abuse Comorbidity in Bipolar Disorder]. Rev Colomb Psiquiatr.
2012 Jun;41(2):371-383. doi: 10.1016/S0034-7450(14)60011-1. Epub 2014 May 10.
Review. Spanish. PubMed PMID: 26573500.

4: Gjestad C, Huynh DK, Haslemo T, Molden E. 4β-Hydroxycholesterol correlates
with dose but not steady-state concentration of carbamazepine: indication of
intestinal CYP3A in biomarker formation? Br J Clin Pharmacol. 2015 Nov 17. doi:
10.1111/bcp.12833. [Epub ahead of print] PubMed PMID: 26574235.