WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 317366
Description: Captopril is an angiotensin-converting enzyme (ACE) inhibitor used for the treatment of hypertension and some types of congestive heart failure. Captopril was the first ACE inhibitor developed and was considered a breakthrough both because of its novel mechanism of action and also because of the revolutionary development process. Captopril was discovered and developed at Squibb and Sons Pharmaceuticals based on concepts pioneered by Nobel Laureate John Vane.
MedKoo Cat#: 317366
Chemical Formula: C9H15NO3S
Exact Mass: 217.07726
Molecular Weight: 217.29
Elemental Analysis: C, 49.75; H, 6.96; N, 6.45; O, 22.09; S, 14.76
Captopril, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.
Synonym: Captopril, Capoten, SQ14225, SQ 14225, SQ-14225, SQ14,225, SQ 14,225, SQ-14,225
IUPAC/Chemical Name: (2S)-1-[(2S)-2-methyl-3-sulfanylpropanoyl]pyrrolidine-2-carboxylic acid
InChi Key: FAKRSMQSSFJEIM-BQBZGAKWSA-N
InChi Code: InChI=1S/C9H15NO3S/c1-6(5-14)8(11)10-4-2-3-7(10)9(12)13/h6-7,14H,2-5H2,1H3,(H,12,13)/t6-,7-/m0/s1
SMILES Code: O=C([C@H]1N(C([C@H](C)CS)=O)CCC1)O
The following data is based on the product molecular weight 217.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Martínez-Aguilar L, Lezama-Martínez D, Orozco-Cortés NV, González-Espinosa C,
Flores-Monroy J, Valencia-Hernández I. Antihypertensive properties of a the novel
morphologic derivative (4-tert-buthyl-2,6-bis (thiomorpholine-4-ilmethyl)phenol).
J Cardiovasc Pharmacol. 2015 Nov 11. [Epub ahead of print] PubMed PMID: 26566152.
2: Gornowicz-Porowska J, Dmochowski M, Pietkiewicz P, Bowszyc-Dmochowska M.
Mucosal-dominant pemphigus vulgaris in a captopril-taking woman with angioedema.
An Bras Dermatol. 2015 Oct;90(5):748-51. doi: 10.1590/abd1806-4841.20153390.
PubMed PMID: 26560224; PubMed Central PMCID: PMC4631244.
3: Tang Y, Hu X, Lu X. Captopril, an angiotensin-converting enzyme inhibitor,
possesses chondroprotective efficacy in a rat model of osteoarthritis through
suppression local renin-angiotensin system. Int J Clin Exp Med. 2015 Aug
15;8(8):12584-92. eCollection 2015. PubMed PMID: 26550169; PubMed Central PMCID: