Captopril
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MedKoo CAT#: 317366

CAS#: 62571-86-2

Description: Captopril is an angiotensin-converting enzyme (ACE) inhibitor used for the treatment of hypertension and some types of congestive heart failure. Captopril was the first ACE inhibitor developed and was considered a breakthrough both because of its novel mechanism of action and also because of the revolutionary development process. Captopril was discovered and developed at Squibb and Sons Pharmaceuticals based on concepts pioneered by Nobel Laureate John Vane.


Chemical Structure

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Captopril
CAS# 62571-86-2

Theoretical Analysis

MedKoo Cat#: 317366
Name: Captopril
CAS#: 62571-86-2
Chemical Formula: C9H15NO3S
Exact Mass: 217.07726
Molecular Weight: 217.29
Elemental Analysis: C, 49.75; H, 6.96; N, 6.45; O, 22.09; S, 14.76

Price and Availability

Size Price Availability Quantity
1.0g USD 190.0 2 Weeks
2.0g USD 350.0 2 Weeks
5.0g USD 550.0 2 Weeks
10.0g USD 850.0 2 Weeks
20.0g USD 1450.0 2 Weeks
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Synonym: Captopril, Capoten, SQ14225, SQ 14225, SQ-14225, SQ14,225, SQ 14,225, SQ-14,225

IUPAC/Chemical Name: (2S)-1-[(2S)-2-methyl-3-sulfanylpropanoyl]pyrrolidine-2-carboxylic acid

InChi Key: FAKRSMQSSFJEIM-BQBZGAKWSA-N

InChi Code: InChI=1S/C9H15NO3S/c1-6(5-14)8(11)10-4-2-3-7(10)9(12)13/h6-7,14H,2-5H2,1H3,(H,12,13)/t6-,7-/m0/s1

SMILES Code: O=C([C@H]1N(C([C@H](C)CS)=O)CCC1)O

Appearance: White to off-white solid powder.

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 217.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Martínez-Aguilar L, Lezama-Martínez D, Orozco-Cortés NV, González-Espinosa C,
Flores-Monroy J, Valencia-Hernández I. Antihypertensive properties of a the novel
morphologic derivative (4-tert-buthyl-2,6-bis (thiomorpholine-4-ilmethyl)phenol).
J Cardiovasc Pharmacol. 2015 Nov 11. [Epub ahead of print] PubMed PMID: 26566152.

2: Gornowicz-Porowska J, Dmochowski M, Pietkiewicz P, Bowszyc-Dmochowska M.
Mucosal-dominant pemphigus vulgaris in a captopril-taking woman with angioedema.
An Bras Dermatol. 2015 Oct;90(5):748-51. doi: 10.1590/abd1806-4841.20153390.
PubMed PMID: 26560224; PubMed Central PMCID: PMC4631244.

3: Tang Y, Hu X, Lu X. Captopril, an angiotensin-converting enzyme inhibitor,
possesses chondroprotective efficacy in a rat model of osteoarthritis through
suppression local renin-angiotensin system. Int J Clin Exp Med. 2015 Aug
15;8(8):12584-92. eCollection 2015. PubMed PMID: 26550169; PubMed Central PMCID:
PMC4612854.