Captopril
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 317366

CAS#: 62571-86-2

Description: Captopril is an angiotensin-converting enzyme (ACE) inhibitor used for the treatment of hypertension and some types of congestive heart failure. Captopril was the first ACE inhibitor developed and was considered a breakthrough both because of its novel mechanism of action and also because of the revolutionary development process. Captopril was discovered and developed at Squibb and Sons Pharmaceuticals based on concepts pioneered by Nobel Laureate John Vane.

Chemical Structure

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Captopril
CAS# 62571-86-2
Handing Instruction

Theoretical Analysis

MedKoo Cat#: 317366
Name: Captopril
CAS#: 62571-86-2
Chemical Formula: C9H15NO3S
Exact Mass: 217.07726
Molecular Weight: 217.29
Elemental Analysis: C, 49.75; H, 6.96; N, 6.45; O, 22.09; S, 14.76

Size Price Shipping out time Quantity
1g USD 190 2 Weeks
2g USD 350 2 Weeks
5g USD 550 2 Weeks
10g USD 850 2 Weeks
20g USD 1450 2 Weeks
Inquire bulk and customized quantity
Pricing updated 2021-03-01. Prices are subject to change without notice.

Captopril, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.

Synonym: Captopril, Capoten, SQ14225, SQ 14225, SQ-14225, SQ14,225, SQ 14,225, SQ-14,225

IUPAC/Chemical Name: (2S)-1-[(2S)-2-methyl-3-sulfanylpropanoyl]pyrrolidine-2-carboxylic acid

InChi Key: FAKRSMQSSFJEIM-BQBZGAKWSA-N

InChi Code: InChI=1S/C9H15NO3S/c1-6(5-14)8(11)10-4-2-3-7(10)9(12)13/h6-7,14H,2-5H2,1H3,(H,12,13)/t6-,7-/m0/s1

SMILES Code: O=C([C@H]1N(C([C@H](C)CS)=O)CCC1)O

Appearance:
White to off-white solid powder.

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001

Handling Instructions:
View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 217.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

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1: Martínez-Aguilar L, Lezama-Martínez D, Orozco-Cortés NV, González-Espinosa C,
Flores-Monroy J, Valencia-Hernández I. Antihypertensive properties of a the novel
morphologic derivative (4-tert-buthyl-2,6-bis (thiomorpholine-4-ilmethyl)phenol).
J Cardiovasc Pharmacol. 2015 Nov 11. [Epub ahead of print] PubMed PMID: 26566152.

2: Gornowicz-Porowska J, Dmochowski M, Pietkiewicz P, Bowszyc-Dmochowska M.
Mucosal-dominant pemphigus vulgaris in a captopril-taking woman with angioedema.
An Bras Dermatol. 2015 Oct;90(5):748-51. doi: 10.1590/abd1806-4841.20153390.
PubMed PMID: 26560224; PubMed Central PMCID: PMC4631244.

3: Tang Y, Hu X, Lu X. Captopril, an angiotensin-converting enzyme inhibitor,
possesses chondroprotective efficacy in a rat model of osteoarthritis through
suppression local renin-angiotensin system. Int J Clin Exp Med. 2015 Aug
15;8(8):12584-92. eCollection 2015. PubMed PMID: 26550169; PubMed Central PMCID:
PMC4612854.

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Captopril

1g / USD 190