WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 522502
Description: AM-3189 is a potent and selective GPR40 Agonist with minimal CNS penetration, superior pharmacokinetic properties and in vivo efficacy comparable to AMG 837. AM-3189 maintains the in vivo efficacy of AMG 837 while displaying a superior pharmacokinetic profile and minimal CNS exposure. Similar to AMG 837, while highly potent on GPR40, AM-3189 was highly selective over the closely related GPCRs, GPR41 and GPR43. 13kdemonstrated low clearance, moderate volume of distribution, and good oral bioavailability. AM-3189 does not penetrate the rat CNS as indicated by a rat brain to plasma ratio of 0.04 at 3 h after an oral dose of 5 mg/kg.
MedKoo Cat#: 522502
Chemical Formula: C27H25ClN2O3
Exact Mass: 460.15537
Molecular Weight: 460.958
Elemental Analysis: C, 70.35; H, 5.47; Cl, 7.69; N, 6.08; O, 10.41
AM-3189, is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to firstname.lastname@example.org to inquire quote.
Synonym: AM-3189; AM 3189; AM3189.
IUPAC/Chemical Name: (S)-3-(4-((4'-chloro-2'-methyl-[1,1'-biphenyl]-3-yl)methoxy)phenyl)-3-(1-methyl-1H-imidazol-2-yl)propanoic acid
InChi Key: GFFXCPIMXLSUGF-VWLOTQADSA-N
InChi Code: InChI=1S/C27H25ClN2O3/c1-18-14-22(28)8-11-24(18)21-5-3-4-19(15-21)17-33-23-9-6-20(7-10-23)25(16-26(31)32)27-29-12-13-30(27)2/h3-15,25H,16-17H2,1-2H3,(H,31,32)/t25-/m0/s1
SMILES Code: ClC1=CC=C(C2=CC=CC(COC3=CC=C([C@@H](C4=NC=CN4C)CC(O)=O)C=C3)=C2)C(C)=C1
The following data is based on the product molecular weight 460.958 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
Zhihua Ma, Daniel C.-H. Lin, Rajiv Sharma, Jinqian Liu, Liusheng Zhu, An-Rong Li, Todd Kohn, Yingcai Wang, Jiwen (Jim) Liu, Michael D. Bartberger, Julio C. Medina, Run Zhuang, Frank Li, Jane Zhang, Jian Luo, Simon Wong, George R. Tonn, Jonathan B. Houze. Discovery of the Imidazole-derived GPR40 Agonist AM-3189. Bioorg. Med. Chem. Lett. In Press, Accepted Manuscript, Available online 17 November 2015.