Bevantolol Hydrochloride | CAS# 42864-78-8 | Beta-1 Adrenoceptor Antagonist

Bevantolol Hydrochloride
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 317322

CAS#: 42864-78-8 (HCl)

Description: Bevantolol Hydrochloride is a beta-1 adrenoceptor antagonist that has been shown to be as effective as other beta blockers for the treatment of angina pectoris and hypertension.

Chemical Structure

Bevantolol Hydrochloride

CAS# 42864-78-8 (HCl)

Instruction

Theoretical Analysis

MedKoo Cat#: 317322
Name: Bevantolol Hydrochloride
CAS#: 42864-78-8 (HCl)
Chemical Formula: C20H28ClNO4
Exact Mass: 0.00
Molecular Weight: 381.890
Elemental Analysis: C, 62.90; H, 7.39; Cl, 9.28; N, 3.67; O, 16.76

Price and Availability

Size	Price	Availability
250mg	USD 350	2 weeks
1g	USD 1050	2 weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Related CAS #: 59170-23-9 (free base) 42864-78-8 (HCl)

Synonym: Bevantolol Hydrochloride; Bevantolol HCl; Vantol; Cl 775; Cl775; Cl 775.

IUPAC/Chemical Name: 1-[2-(3,4-dimethoxyphenyl)ethylamino]-3-(3-methylphenoxy)propan-2-ol;hydrochloride

InChi Key: FJTKCFSPYUMXJB-UHFFFAOYSA-N

InChi Code: InChI=1S/C20H27NO4.ClH/c1-15-5-4-6-18(11-15)25-14-17(22)13-21-10-9-16-7-8-19(23-2)20(12-16)24-3;/h4-8,11-12,17,21-22H,9-10,13-14H2,1-3H3;1H

SMILES Code: OC(COC1=CC=CC(C)=C1)CNCCC2=CC=C(OC)C(OC)=C2.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 381.89 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Kaplan HR. Bevantolol hydrochloride--preclinical pharmacologic profile. Angiology. 1986 Mar;37(3 Pt 2):254-62. doi: 10.1177/000331978603700319. PMID: 2871786.

2: Löfdahl CG, Svedmyr K, Svedmyr N. Selectivity of bevantolol hydrochloride, a beta 1-adrenoceptor antagonist, in asthmatic patients. Pharmacotherapy. 1984 Jul-Aug;4(4):205-10. doi: 10.1002/j.1875-9114.1984.tb03359.x. PMID: 6148733.

3: Takita M, Kigoshi S, Muramatsu I. Selectivity of bevantolol hydrochloride towards alpha- and beta-adrenoceptor subtypes in rat cerebral cortex. Jpn J Pharmacol. 1992 Feb;58(2):193-6. doi: 10.1254/jjp.58.193. PMID: 1354761.

4: Frishman WH, Goldberg RJ, Benfield P. Bevantolol. A preliminary review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in hypertension and angina pectoris. Drugs. 1988 Jan;35(1):1-21. doi: 10.2165/00003495-198835010-00001. PMID: 2894292.

5: Vaughan Williams EM. Bevantolol: a beta-1 adrenoceptor antagonist with unique additional actions. J Clin Pharmacol. 1987 Jul;27(7):450-60. doi: 10.1002/j.1552-4604.1987.tb03049.x. PMID: 2888789.

6: Kaplan HR. Pharmacology of bevantolol hydrochloride. Am J Cardiol. 1986 Nov 26;58(12):3E-7E. doi: 10.1016/0002-9149(86)90590-4. PMID: 2878599.

7: Ren L, Wang Z, Lou Y, Zheng L, Zheng H, Yin C. Determination of bevantolol in human plasma using liquid chromatography-electrospray ionization tandem mass spectrometry and its application to a bioequivalence study. J Chromatogr B Analyt Technol Biomed Life Sci. 2014 May 15;959:16-21. doi: 10.1016/j.jchromb.2014.03.040. Epub 2014 Apr 13. PMID: 24747519.

8: Oh JW, Trung TQ, Sin KS, Kang JS, Kim KH. Determination of bevantolol enantiomers in human plasma by coupled achiral-chiral high performance-liquid chromatography. Chirality. 2007 Jul;19(7):528-35. doi: 10.1002/chir.20410. PMID: 17457831.

9: Bowles MJ, Khurmi NS, O'Hara MJ, Raftery EB. Usefulness of bevantolol for chronic, stable angina pectoris. Am J Cardiol. 1986 Nov 26;58(12):28E-34E. doi: 10.1016/0002-9149(86)90595-3. PMID: 2878598.

10: Farnham DJ. Effectiveness of bevantolol in the treatment of angina--a placebo-controlled study. Angiology. 1986 Mar;37(3 Pt 2):226-32. doi: 10.1177/000331978603700314. PMID: 2871782.

11: Latts JR. Clinical pharmacokinetics and metabolism of bevantolol. Angiology. 1986 Mar;37(3 Pt 2):221-5. doi: 10.1177/000331978603700313. PMID: 2871781.

12: Dukes ID, Vaughan Williams EM. Cardiovascular effects of bevantolol, a selective beta 1-adrenoceptor antagonist with a novel pharmacological profile. Br J Pharmacol. 1985 Feb;84(2):365-80. doi: 10.1111/j.1476-5381.1985.tb12921.x. PMID: 2858236; PMCID: PMC1987306.

13: Gamez J, Calopa M, Muñoz E, Ferré A, Huertas O, McAllister K, Reig N, Scart- Grès C, Insa R, Kulisevsky J. A proof-of-concept study with SOM3355 (bevantolol hydrochloride) for reducing chorea in Huntington's disease. Br J Clin Pharmacol. 2023 May;89(5):1656-1664. doi: 10.1111/bcp.15635. Epub 2022 Dec 28. PMID: 36494329.

14: Fairhurst GJ. Comparison of bevantolol and atenolol for systemic hypertension. Am J Cardiol. 1986 Nov 26;58(12):25E-27E. doi: 10.1016/0002-9149(86)90594-1. PMID: 2878597.

15: Bray JS. Safety profile of bevantolol. Angiology. 1986 Mar;37(3 Pt 2):248-53. doi: 10.1177/000331978603700318. PMID: 2871785.

16: Maclean D. Bevantolol vs propranolol: a double-blind controlled trial in essential hypertension. Angiology. 1988 Jun;39(6):487-96. doi: 10.1177/000331978803900601. PMID: 2897812.

17: Noshiro T, Miura Y, Yoshinaga K, Iimura O, Inagaki Y, Saruta T, Ishii M, Yamazaki N, Arakawa K. Clinical evaluation of bevantolol hydrochloride in patients with severe hypertension. The Cooperative Study Group on Bevantolol in Japan. Int J Clin Pharmacol Ther. 1995 Apr;33(4):240-5. PMID: 7620695.

18: Shiraishi K, Moriya M, Miyake N, Takayanagi I. Alpha 1-adrenoceptor blocking activities of bevantolol hydrochloride(NC-1400) and labetalol in rat isolated thoracic aorta--do they distinguish between subtypes? Gen Pharmacol. 1992 Sep;23(5):843-5. doi: 10.1016/0306-3623(92)90235-c. PMID: 1358746.

19: Long PH, Trung TQ, Oh JW, Kim KH. Chiral purity test of bevantolol by capillaryelectrophoresis and high performance liquid chromatography. Arch Pharm Res. 2006 Sep;29(9):808-13. doi: 10.1007/BF02974083. PMID: 17024856.

20: Wong GW, Boyda HN, Wright JM. Blood pressure lowering efficacy of beta-1 selective beta blockers for primary hypertension. Cochrane Database Syst Rev. 2016 Mar 10;3(3):CD007451. doi: 10.1002/14651858.CD007451.pub2. PMID: 26961574; PMCID: PMC6486283.

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