Betaxolol Hydrochloride

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 317320

CAS#: 63659-19-8

Description: Betaxolol Hydrochloride is the hydrochloride salt form of betaxolol, a β1-AR selective adrenergic receptor antagonist. Betaxolol hydrochloride acts on the heart and circulatory system and decreases cardiac contractility and rate, and cardiac output levels. When applied topically in the eye, it lowers intraocular pressure by reducing aqueous humor secretion.

Chemical Structure

Betaxolol Hydrochloride
CAS# 63659-19-8

Theoretical Analysis

MedKoo Cat#: 317320
Name: Betaxolol Hydrochloride
CAS#: 63659-19-8
Chemical Formula: C18H30ClNO3
Exact Mass:
Molecular Weight: 343.89
Elemental Analysis: C, 62.87; H, 8.79; Cl, 10.31; N, 4.07; O, 13.96

Price and Availability

Size Price Availability Quantity
5.0mg USD 135.0 2 weeks
10.0mg USD 160.0 2 weeks
50.0mg USD 225.0 2 weeks
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Synonym: Betaxolol Hydrochloride; Betaxolol HCL; Betoptima; Kerlone; Betoptic; Kerlon; ALO 140102; ALO-1401-02; ALO140102

IUPAC/Chemical Name: Chemical Name: 1-[4-[2-(Cyclopropylmethoxy)ethyl]phenoxy]-3-isopropylamino-2-propanol hydrochloride


InChi Code: InChI=1S/C18H29NO3.ClH/c1-14(2)19-11-17(20)13-22-18-7-5-15(6-8-18)9-10-21-12-16-3-4-16;/h5-8,14,16-17,19-20H,3-4,9-13H2,1-2H3;1H


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 343.89 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Auvity S, Chiadmi F, Cisternino S, Fontan JE, Schlatter J. A Rapid Stability-Indicating RP-HPLC Method for the Determination of Betaxolol Hydrochloride in Pharmaceutical Tablets. Anal Chem Insights. 2013;8:1-7. doi: 10.4137/ACI.S11256. Epub 2013 Mar 11. PubMed PMID: 23531643; PubMed Central
PMCID: PMC3603494.

2: Jain K, Kumar RS, Sood S, Dhyanandhan G. Betaxolol hydrochloride loaded chitosan nanoparticles for ocular delivery and their anti-glaucoma efficacy. Curr Drug Deliv. 2013 Oct;10(5):493-9. PubMed PMID: 23410069.

3: Plager DA, Whitson JT, Netland PA, Vijaya L, Sathyan P, Sood D, Krishnadas SR, Robin AL, Gross RD, Scheib SA, Scott H, Dickerson JE; BETOPTIC S Pediatric Study Group. Betaxolol hydrochloride ophthalmic suspension 0.25% and timolol gel-forming solution 0.25% and 0.5% in pediatric glaucoma: a randomized clinical trial. J AAPOS. 2009 Aug;13(4):384-90. doi: 10.1016/j.jaapos.2009.04.017. PubMed PMID: 19683191.