Bambuterol Hydrochloride
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MedKoo CAT#: 317309

CAS#: 81732-46-9

Description: Bambuterol Hydrochloride is a long acting beta-adrenoceptor agonist used in the treatment of asthma. Bambuterol Hydrochloride acts as a bronchodilator. It inhibits plasma BChE (cholinesterase) during metabolism prolongs suxamethonium-induced neuromuscular blockade.


Chemical Structure

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Bambuterol Hydrochloride
CAS# 81732-46-9

Theoretical Analysis

MedKoo Cat#: 317309
Name: Bambuterol Hydrochloride
CAS#: 81732-46-9
Chemical Formula: C18H30ClN3O5
Exact Mass:
Molecular Weight: 403.9
Elemental Analysis: C, 53.53; H, 7.49; Cl, 8.78; N, 10.40; O, 19.81

Price and Availability

Size Price Availability Quantity
5.0mg USD 50.0 2 Weeks
10.0mg USD 60.0 2 Weeks
25.0mg USD 70.0 2 Weeks
50.0mg USD 80.0 2 Weeks
100.0mg USD 90.0 2 Weeks
200.0mg USD 120.0 2 Weeks
500.0mg USD 150.0 2 Weeks
1.0g USD 250.0 2 Weeks
2.0g USD 450.0 2 Weeks
5.0g USD 950.0 2 Weeks
10.0g USD 1650.0 2 Weeks
20.0g USD 2750.0 2 Weeks
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Synonym: Bambuterol Hydrochloride; UNII-Y1850G1OVC; Bambuterol HCl; CHEBI:59167;DSSTox_CID_25515

IUPAC/Chemical Name: [3-[2-(tert-butylamino)-1-hydroxyethyl]-5-(dimethylcarbamoyloxy)phenyl] N,N-dimethylcarbamate;hydrochloride

InChi Key: LBARATORRVNNQM-UHFFFAOYSA-N

InChi Code: InChI=1S/C18H29N3O5.ClH/c1-18(2,3)19-11-15(22)12-8-13(25-16(23)20(4)5)10-14(9-12)26-17(24)21(6)7;/h8-10,15,19,22H,11H2,1-7H3;1H

SMILES Code: CC(C)(C)NCC(C1=CC(=CC(=C1)OC(=O)N(C)C)OC(=O)N(C)C)O.Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 403.9 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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Impact of Ternary Solvent System in Stability-Indicating Assay Method of
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2: Li T, Cao J, Li Z, Wang X, He P. Broad screening and identification of
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3: Wang Y, Qin F, Xiong Z, Fu X, Ma C. An LC-MS/MS method for simultaneous
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4: Ye Y, Xu H, Quan L, Zhu L, Zeng J, Zhou T, Zou C, Cheng Q, Bu S, Tan W. The
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5: Zhou T, Liu S, Zhao T, Zeng J, He M, Xu B, Qu S, Xu L, Tan W. Chiral analysis
of bambuterol, its intermediate and active drug in human plasma by liquid
chromatography-tandem mass spectrometry: Application to a pharmacokinetic study.
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6: Li Q, Wang J, Zheng YY, Yang L, Zhang Y, Bian L, Zheng J, Li Z, Zhao X, Zhang
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7: Lamie NT. Application of a new spectrophotometric method manipulating ratio
spectra for determination of bambuterol hydrochloride in the presence of its
degradation product terbutaline. Guang Pu Xue Yu Guang Pu Fen Xi. 2015
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8: Huang J, Lu Y, Wan Q, Zhang M, Pei Q, Zhang M, Liu G, Yang G. Simultaneous
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butyrylcholinesterase by the enantiomers of bambuterol and their intermediates.
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10: Gao F, Wu M, Zhang Y, Wang G, Wang Q, He P, Fang Y. Sensitive determination
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pharmacokinetics and bile transformation of R-enantiomer and racemic bambuterol
after single-dose intravenous, oral administration in rats and beagle dogs. Eur J
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12: Petrov KA, Girard E, Nikitashina AD, Colasante C, Bernard V, Nurullin L,
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13: Zhou T, Cheng Q, Zou C, Zhao T, Liu S, Pistolozzi M, Tan E, Xu L, Tan W.
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plasma by hydrophilic interaction ultra-performance liquid chromatography-tandem
mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Sep
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15: Zhou T, Zhao T, Cheng Q, Liu S, Xu L, Tan W. A sensitive LC-MS/MS method for
simultaneous determination of R-bambuterol and its active metabolite
R-terbutaline in human plasma and urine with application to a clinical
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19: Yanamandra R, Vadla CS, Puppala UM, Patro B, Murthy YL, Parimi AR.
Development and Validation of a Rapid RP-UPLC Method for the Simultaneous
Estimation of Bambuterol Hydrochloride and Montelukast Sodium from Tablets.
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PMID: 23325991; PubMed Central PMCID: PMC3546327.

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prodrug administration, using a joined in vitro/in silico-in vivo extrapolation
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