WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 317365
CAS#: 118785-03-8
Description: Candoxatril is the orally active prodrug of candoxatrilat (UK-73967) human neutral endopeptidase (Neprilysin) as the neutral endopeptidase 24.11 complexed (RB-101) with phosphoramidon degrades and inactivates a number of bioactive peptides. Two multiply connected folding domains of the neutral endopeptidase locus splicing of exons 1, 2a, or 2b to the common exon 3 composed of 24 exons of the human CALLA/NEP gene containing the active site, it is known as peptidase family M13 the gluzincins a faint but significant structural relationship of the metzincins to the thermolysin-like enzymes, Zincin is the simplest descriptor of biological space.
MedKoo Cat#: 317365
Name: Candoxatril
CAS#: 118785-03-8
Chemical Formula: C29H41NO7
Exact Mass: 515.2883
Molecular Weight: 515.64
Elemental Analysis: C, 67.55; H, 8.01; N, 2.72; O, 21.72
Candoxatril purity 98% is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.
Synonym: UK 79300, UK-79300, UK79300, Candoxatril
IUPAC/Chemical Name: 4-[[1-[(2S)-3-(2,3-dihydro-1H-inden-5-yloxy)-2-(2-methoxyethoxymethyl)-3-oxopropyl]cyclopentanecarbonyl]amino]cyclohexane-1-carboxylic acid
InChi Key: ZTWZVMIYIIVABD-RZMWZJFBSA-N
InChi Code: InChI=1S/C29H41NO7/c1-35-15-16-36-19-23(27(33)37-25-12-9-20-5-4-6-22(20)17-25)18-29(13-2-3-14-29)28(34)30-24-10-7-21(8-11-24)26(31)32/h9,12,17,21,23-24H,2-8,10-11,13-16,18-19H2,1H3,(H,30,34)(H,31,32)/t21?,23-,24?/m0/s1
SMILES Code: O=C(C1CCC(NC(C2(C[C@@H](COCCOC)C(OC3=CC4=C(CCC4)C=C3)=O)CCCC2)=O)CC1)O
The following data is based on the product molecular weight 515.64 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Singh JS, Lang CC. Angiotensin receptor-neprilysin inhibitors: clinical
potential in heart failure and beyond. Vasc Health Risk Manag. 2015 Jun
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2: Vardeny O, Miller R, Solomon SD. Combined neprilysin and renin-angiotensin
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inhibitor versus angiotensin converting enzyme inhibitor in a rat model of the
metabolic syndrome. J Am Soc Hypertens. 2014 Apr;8(4):227-31. doi:
10.1016/j.jash.2014.01.006. Epub 2014 Jan 24. PubMed PMID: 24560177.