Candesartan
featured

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 317364

CAS#: 139481-59-7

Description: Candesartan is an angiotensin II receptor antagonist used mainly for the treatment of hypertension. Candesartan is marketed as the cyclohexyl 1-hydroxyethyl carbonate (cilexetil) ester, known as candesartan cilexetil. Candesartan cilexetil is metabolised completely by esterases in the intestinal wall during absorption to the active candesartan moieity. The use of a prodrug form increases the bioavailability of candesartan. Despite this, absolute bioavailability is relatively poor at 15% (candesartan cilexetil tablets) to 40% (candesartan cilexetil solution). Its IC50 is 15 µg/kg.


Chemical Structure

img
Candesartan
CAS# 139481-59-7

Theoretical Analysis

MedKoo Cat#: 317364
Name: Candesartan
CAS#: 139481-59-7
Chemical Formula: C24H20N6O3
Exact Mass: 440.15969
Molecular Weight: 440.45
Elemental Analysis: C, 65.45; H, 4.58; N, 19.08; O, 10.90

Price and Availability

Size Price Availability Quantity
100.0mg USD 90.0 Same day
200.0mg USD 150.0 Same day
500.0mg USD 250.0 Same day
1.0g USD 450.0 Same day
2.0g USD 850.0 Same day
Bulk inquiry

Synonym: Candesartan, CV11974, CV-1197, CV 11974, Trade names: Blopress, Atacand, Amias, and Ratacand

IUPAC/Chemical Name: 2-ethoxy-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]benzimidazole-4-carboxylic acid

InChi Key: HTQMVQVXFRQIKW-UHFFFAOYSA-N

InChi Code: InChI=1S/C24H20N6O3/c1-2-33-24-25-20-9-5-8-19(23(31)32)21(20)30(24)14-15-10-12-16(13-11-15)17-6-3-4-7-18(17)22-26-28-29-27-22/h3-13H,2,14H2,1H3,(H,31,32)(H,26,27,28,29)

SMILES Code: O=C(C1=C2N(CC3=CC=C(C4=CC=CC=C4C5=NNN=N5)C=C3)C(OCC)=NC2=CC=C1)O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Certificate of Analysis:

Safety Data Sheet (SDS):

Preparing Stock Solutions

The following data is based on the product molecular weight 440.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Wolska E, Kluk A, Zarazińska M, Boniecka M, Sznitowska M. Choice of excipients
for gelly-like pulp prepared ex tempore "on a spoon"- "placebo" and with sartans.
Drug Dev Ind Pharm. 2015 Nov 7:1-10. [Epub ahead of print] PubMed PMID: 26548554.

2: Enatsu N, Miyake H, Chiba K, Fujisawa M. Candesartan Mediated Amelioration of
Cisplatin-Induced Testicular Damage Is Associated with Alterations in Expression
Patterns of Nephrin and Podocin. Biomed Res Int. 2015;2015:273784. doi:
10.1155/2015/273784. Epub 2015 Oct 11. PubMed PMID: 26539476; PubMed Central
PMCID: PMC4619786.

3: Quiñones MM, Maldonado L, Velazquez B, Porter JT. Candesartan ameliorates
impaired fear extinction induced by innate immune activation. Brain Behav Immun.
2015 Oct 28. pii: S0889-1591(15)30043-X. doi: 10.1016/j.bbi.2015.10.017. [Epub
ahead of print] PubMed PMID: 26520214.