WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 317364
Description: Candesartan is an angiotensin II receptor antagonist used mainly for the treatment of hypertension. Candesartan is marketed as the cyclohexyl 1-hydroxyethyl carbonate (cilexetil) ester, known as candesartan cilexetil. Candesartan cilexetil is metabolised completely by esterases in the intestinal wall during absorption to the active candesartan moieity. The use of a prodrug form increases the bioavailability of candesartan. Despite this, absolute bioavailability is relatively poor at 15% (candesartan cilexetil tablets) to 40% (candesartan cilexetil solution). Its IC50 is 15 µg/kg.
MedKoo Cat#: 317364
Chemical Formula: C24H20N6O3
Exact Mass: 440.15969
Molecular Weight: 440.45
Elemental Analysis: C, 65.45; H, 4.58; N, 19.08; O, 10.90
Synonym: Candesartan, CV11974, CV-1197, CV 11974, Trade names: Blopress, Atacand, Amias, and Ratacand
IUPAC/Chemical Name: 2-ethoxy-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]benzimidazole-4-carboxylic acid
InChi Key: HTQMVQVXFRQIKW-UHFFFAOYSA-N
InChi Code: InChI=1S/C24H20N6O3/c1-2-33-24-25-20-9-5-8-19(23(31)32)21(20)30(24)14-15-10-12-16(13-11-15)17-6-3-4-7-18(17)22-26-28-29-27-22/h3-13H,2,14H2,1H3,(H,31,32)(H,26,27,28,29)
SMILES Code: O=C(C1=C2N(CC3=CC=C(C4=CC=CC=C4C5=NNN=N5)C=C3)C(OCC)=NC2=CC=C1)O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 440.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Wolska E, Kluk A, Zarazińska M, Boniecka M, Sznitowska M. Choice of excipients
for gelly-like pulp prepared ex tempore "on a spoon"- "placebo" and with sartans.
Drug Dev Ind Pharm. 2015 Nov 7:1-10. [Epub ahead of print] PubMed PMID: 26548554.
2: Enatsu N, Miyake H, Chiba K, Fujisawa M. Candesartan Mediated Amelioration of
Cisplatin-Induced Testicular Damage Is Associated with Alterations in Expression
Patterns of Nephrin and Podocin. Biomed Res Int. 2015;2015:273784. doi:
10.1155/2015/273784. Epub 2015 Oct 11. PubMed PMID: 26539476; PubMed Central
3: Quiñones MM, Maldonado L, Velazquez B, Porter JT. Candesartan ameliorates
impaired fear extinction induced by innate immune activation. Brain Behav Immun.
2015 Oct 28. pii: S0889-1591(15)30043-X. doi: 10.1016/j.bbi.2015.10.017. [Epub
ahead of print] PubMed PMID: 26520214.