Tymazoline HCl

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 318963

CAS#: 28120-03-8 (hydrochloride)

Description: Tymazoline (trade name Thymazen in Poland) is a nasal decongestant that can be used to treat rhinitis. It acts as an antihistaminic and sympathomimetic, reducing swelling, inflammation and mucosal secretions.

Chemical Structure

Tymazoline HCl
CAS# 28120-03-8 (hydrochloride)

Theoretical Analysis

MedKoo Cat#: 318963
Name: Tymazoline HCl
CAS#: 28120-03-8 (hydrochloride)
Chemical Formula: C14H21ClN2O
Exact Mass:
Molecular Weight: 268.785
Elemental Analysis: C, 62.56; H, 7.88; Cl, 13.19; N, 10.42; O, 5.95

Price and Availability

Size Price Availability Quantity
200.0mg USD 450.0 2 Weeks
500.0mg USD 650.0 2 Weeks
1.0g USD 950.0 2 Weeks
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Related CAS #: 28120-03-8 (hydrochloride)   24243-97-8 (free base)  

Synonym: D08658; Tymazoline HCl, trade name: Thymazen; Pernazene.

IUPAC/Chemical Name: 2-[(5-methyl-2-propan-2-ylphenoxy)methyl]-4,5-dihydro-1H-imidazole hydrochloride


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 268.785 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Antoniou CG, Markopoulou CK, Kouskoura MG, Koundourellis JE. Study and
development of reversed-phase HPLC systems for the determination of
2-imidazolines in the presence of preservatives in pharmaceutical preparations. J
AOAC Int. 2011 May-Jun;94(3):703-12. PubMed PMID: 21796997.

2: Levrier J, Molon-Noblot S, Duval D, Lloyd KG. A new ex vivo method for the
study of nasal drops on ciliary function. Fundam Clin Pharmacol.
1989;3(5):471-82. PubMed PMID: 2481638.