Benazepril hydrochloride

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 317310

CAS#: 86541-74-4 (HCl)

Description: Benazepril Hydrochloride is the hydrochloride salt of benazepril, a carboxyl-containing angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. Benazeprilat competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II, resulting in vasodilation. Benazeprilat also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow. Benazepril hydrochloride reduces blood pressure and myocardial hypertrophy in spontaneous hypertensive rats.

Chemical Structure

Benazepril hydrochloride
CAS# 86541-74-4 (HCl)

Theoretical Analysis

MedKoo Cat#: 317310
Name: Benazepril hydrochloride
CAS#: 86541-74-4 (HCl)
Chemical Formula: C24H29ClN2O5
Exact Mass:
Molecular Weight: 460.95
Elemental Analysis: C, 62.54; H, 6.34; Cl, 7.69; N, 6.08; O, 17.35

Price and Availability

Size Price Availability Quantity
100.0mg USD 150.0 2 weeks
200.0mg USD 250.0 2 weeks
500.0mg USD 450.0 2 weeks
1.0g USD 650.0 2 weeks
2.0g USD 950.0 2 weeks
5.0g USD 1650.0 2 weeks
Bulk inquiry

Related CAS #: 86541-75-5 (free base)   86541-74-4 (HCl)    

Synonym: Benazepril hydrochloride; Benazepril; benazepril hydrochloride; benzazepril; Briem; CGS-14824-A; CGS-14824A; Cibacène; Cibacen; Labopal; Lotensin

IUPAC/Chemical Name: (3S)-3-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepine-1-acetic acid hydrochloride


InChi Code: InChI=1S/C24H28N2O5.ClH/c1-2-31-24(30)20(14-12-17-8-4-3-5-9-17)25-19-15-13-18-10-6-7-11-21(18)26(23(19)29)16-22(27)28;/h3-11,19-20,25H,2,12-16H2,1H3,(H,27,28);1H/t19-,20-;/m0./s1

SMILES Code: O=C(O)CN1C([C@@H](N[C@H](C(OCC)=O)CCC2=CC=CC=C2)CCC3=CC=CC=C31)=O.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 460.95 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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