WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 317362
Description: Butoconazole is an imidazole antifungal used in gynecology. It is administered as a vaginal cream.
MedKoo Cat#: 317362
Name: Butoconazole Nitrate
Chemical Formula: C19H18Cl3N3O3S
Molecular Weight: 474.781
Elemental Analysis: C, 48.07; H, 3.82; Cl, 22.40; N, 8.85; O, 10.11; S, 6.75
Synonym: Butoconazole, Gynazole-1, Mycelex-3, RS35887, RS-35887, RS 35887; Butoconazole Nitrate
IUPAC/Chemical Name: 1-[4-(4-chlorophenyl)-2-(2,6-dichlorophenyl)sulfanylbutyl]imidazole nitrate
InChi Key: ZHPWRQIPPNZNML-UHFFFAOYSA-N
InChi Code: InChI=1S/C19H17Cl3N2S.HNO3/c20-15-7-4-14(5-8-15)6-9-16(12-24-11-10-23-13-24)25-19-17(21)2-1-3-18(19)22;2-1(3)4/h1-5,7-8,10-11,13,16H,6,9,12H2;(H,2,3,4)
SMILES Code: ClC1=C(SC(CCC2=CC=C(Cl)C=C2)CN3C=CN=C3)C(Cl)=CC=C1.O[N+]([O-])=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 474.781 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Jia MM, Zhou Y, He XM, Wu YL, Li HQ, Chen H, Li WY. Development of a liquid
chromatography-tandem mass spectrometry method for determination of butoconazole
nitrate in human plasma and its application to a pharmacokinetic study. J
Huazhong Univ Sci Technolog Med Sci. 2014 Jun;34(3):431-6. doi:
10.1007/s11596-014-1296-y. Epub 2014 Jun 18. PubMed PMID: 24939312.
2: Heng LZ, Chen Y, Tan TC. Treatment of recurrent vulvo-vaginal candidiasis with
sustained-released butoconazole pessary. Singapore Med J. 2012
Dec;53(12):e269-71. PubMed PMID: 23268172.
3: Expert Board of Polish Gynecological Society. [The statement of Polish
Gynecological Society Experts on the treatment of acute vulvovaginal candidiasis
with prolonged releasing 2% butoconazole nitrate vaginal cream--state of art in
2008]. Ginekol Pol. 2009 Apr;80(4):303-11. Polish. PubMed PMID: 19507567.