Butoconazole Nitrate
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 317362

CAS#: 64872-77-1

Description: Butoconazole is an imidazole antifungal used in gynecology. It is administered as a vaginal cream.


Chemical Structure

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Butoconazole Nitrate
CAS# 64872-77-1

Theoretical Analysis

MedKoo Cat#: 317362
Name: Butoconazole Nitrate
CAS#: 64872-77-1
Chemical Formula: C19H18Cl3N3O3S
Exact Mass:
Molecular Weight: 474.781
Elemental Analysis: C, 48.07; H, 3.82; Cl, 22.40; N, 8.85; O, 10.11; S, 6.75

Price and Availability

Size Price Availability Quantity
10.0mg USD 60.0 2 Weeks
25.0mg USD 70.0 2 Weeks
50.0mg USD 80.0 2 Weeks
100.0mg USD 90.0 2 Weeks
200.0mg USD 120.0 2 Weeks
500.0mg USD 150.0 2 Weeks
1.0g USD 250.0 2 Weeks
2.0g USD 450.0 2 Weeks
5.0g USD 950.0 2 Weeks
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Synonym: Butoconazole, Gynazole-1, Mycelex-3, RS35887, RS-35887, RS 35887; Butoconazole Nitrate

IUPAC/Chemical Name: 1-[4-(4-chlorophenyl)-2-(2,6-dichlorophenyl)sulfanylbutyl]imidazole nitrate

InChi Key: ZHPWRQIPPNZNML-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H17Cl3N2S.HNO3/c20-15-7-4-14(5-8-15)6-9-16(12-24-11-10-23-13-24)25-19-17(21)2-1-3-18(19)22;2-1(3)4/h1-5,7-8,10-11,13,16H,6,9,12H2;(H,2,3,4)

SMILES Code: ClC1=C(SC(CCC2=CC=C(Cl)C=C2)CN3C=CN=C3)C(Cl)=CC=C1.O[N+]([O-])=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 474.781 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Jia MM, Zhou Y, He XM, Wu YL, Li HQ, Chen H, Li WY. Development of a liquid
chromatography-tandem mass spectrometry method for determination of butoconazole
nitrate in human plasma and its application to a pharmacokinetic study. J
Huazhong Univ Sci Technolog Med Sci. 2014 Jun;34(3):431-6. doi:
10.1007/s11596-014-1296-y. Epub 2014 Jun 18. PubMed PMID: 24939312.

2: Heng LZ, Chen Y, Tan TC. Treatment of recurrent vulvo-vaginal candidiasis with
sustained-released butoconazole pessary. Singapore Med J. 2012
Dec;53(12):e269-71. PubMed PMID: 23268172.

3: Expert Board of Polish Gynecological Society. [The statement of Polish
Gynecological Society Experts on the treatment of acute vulvovaginal candidiasis
with prolonged releasing 2% butoconazole nitrate vaginal cream--state of art in
2008]. Ginekol Pol. 2009 Apr;80(4):303-11. Polish. PubMed PMID: 19507567.