WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 317361

CAS#: 101828-21-1 (free base)

Description: Butenafine hydrochloride is an odorless white crystalline powder that is freely soluble in methanol, ethanol, and chloroform, and slightly soluble in water. Like the allylamine antifungals, butenafine works by inhibiting the synthesis of ergosterol by inhibiting squalene epoxidase, an enzyme responsible for the creation of sterols needed in fungal cell membranes. Lacking ergosterol, the cell membranes increase in permeability, allowing their contents to leak out.

Chemical Structure

CAS# 101828-21-1 (free base)

Theoretical Analysis

MedKoo Cat#: 317361
Name: Butenafine
CAS#: 101828-21-1 (free base)
Chemical Formula: C23H27N
Exact Mass: 317.21435
Molecular Weight: 317.47
Elemental Analysis: C, 87.02; H, 8.57; N, 4.41

Price and Availability

Size Price Availability Quantity
10.0mg USD 220.0 2 Weeks
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Synonym: Butenafine, Mentax, Butop, KP363, KP 363, KP-363

IUPAC/Chemical Name: 1-(4-tert-butylphenyl)-N-methyl-N-(naphthalen-1-ylmethyl)methanamine


InChi Code: InChI=1S/C23H27N/c1-23(2,3)21-14-12-18(13-15-21)16-24(4)17-20-10-7-9-19-8-5-6-11-22(19)20/h5-15H,16-17H2,1-4H3


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 317.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

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1: Fu MC, Shang R, Cheng WM, Fu Y. Boron-Catalyzed N-Alkylation of Amines using
Carboxylic Acids. Angew Chem Int Ed Engl. 2015 Jul 27;54(31):9042-6. doi:
10.1002/anie.201503879. Epub 2015 Jul 6. PubMed PMID: 26150397.

2: Pillai AB, Nair JV, Gupta NK, Gupta S. Microemulsion-loaded hydrogel
formulation of butenafine hydrochloride for improved topical delivery. Arch
Dermatol Res. 2015 Sep;307(7):625-33. doi: 10.1007/s00403-015-1573-z. Epub 2015
May 26. PubMed PMID: 26006164.

3: Ely JW, Rosenfeld S, Seabury Stone M. Diagnosis and management of tinea
infections. Am Fam Physician. 2014 Nov 15;90(10):702-10. PubMed PMID: 25403034.

Additional Information

101828-21-1 (Butenafine free base)
101827-46-7 (Butenafine HCl).