Betamethasone Valerate

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 317319

CAS#: 2152-44-5

Description: Betamethasone Valerate is the 17-valerate derivative of Betamethasone. Betamethasone Valerate acts as a moderately potent glucocorticoid steroid with anti-inflammatory and immunosuppressive properties. Betamethasone valerate binds to specific intracellular glucocorticoid receptors and subsequently binds to DNA to modify gene expression. The synthesis of certain anti-inflammatory proteins is induced while the synthesis of certain inflammatory mediators is inhibited.

Chemical Structure

Betamethasone Valerate
CAS# 2152-44-5

Theoretical Analysis

MedKoo Cat#: 317319
Name: Betamethasone Valerate
CAS#: 2152-44-5
Chemical Formula: C27H37FO6
Exact Mass: 476.2574
Molecular Weight: 476.5854
Elemental Analysis: C, 68.05; H, 7.83; F, 3.99; O, 20.14

Price and Availability

Size Price Availability Quantity
100.0mg USD 450.0 2 weeks
200.0mg USD 750.0 2 weeks
500.0mg USD 950.0 2 weeks
1.0g USD 1450.0 2 weeks
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Synonym: Betamethasone Valerate; Betoid; Valison; 9α-Fluo; Valisone; Bedermin; Betneval; Beta-Val; Bextasol; Dermosol; Stanoval

IUPAC/Chemical Name: (8S,9R,10S,11S,13S,14S,16S,17R)-9-fluoro-11-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl pentanoate


InChi Code: InChI=1S/C27H37FO6/c1-5-6-7-23(33)34-27(22(32)15-29)16(2)12-20-19-9-8-17-13-18(30)10-11-24(17,3)26(19,28)21(31)14-25(20,27)4/h10-11,13,16,19-21,29,31H,5-9,12,14-15H2,1-4H3/t16-,19-,20-,21-,24-,25-,26-,27-/m0/s1

SMILES Code: O=C1C=C[C@@]2([C@]3([C@H](C[C@@]4([C@](OC(CCCC)=O)([C@H](C[C@]4([C@@]3(CCC2=C1)[H])[H])C)C(CO)=O)C)O)F)C

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 476.5854 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Maccari F. Improvement of inflammatory dermatoses severity and quality of life
in patients treated with a betamethasone valerate plaster (LIBERE study). J
Dermatolog Treat. 2015 Jun 15:1-5. [Epub ahead of print] PubMed PMID: 25898980.

2: Lotfy HM, Salem H, Abdelkawy M, Samir A. Spectrophotometric methods for
simultaneous determination of betamethasone valerate and fusidic acid in their
binary mixture. Spectrochim Acta A Mol Biomol Spectrosc. 2015 Apr 5;140:294-304.
doi: 10.1016/j.saa.2014.12.059. Epub 2015 Jan 9. PubMed PMID: 25615682.

3: Chittock J, Brown K, Cork MJ, Danby SG. Comparing the Effect of a Twice-weekly
Tacrolimus and Betamethasone Valerate Dose on the Subclinical Epidermal Barrier
Defect in Atopic Dermatitis. Acta Derm Venereol. 2015 Jun 24;95(6):653-8. doi:
10.2340/00015555-2048. PubMed PMID: 25594610.

4: Danby SG, Chittock J, Brown K, Albenali LH, Cork MJ. The effect of tacrolimus
compared with betamethasone valerate on the skin barrier in volunteers with
quiescent atopic dermatitis. Br J Dermatol. 2014 Apr;170(4):914-21. doi:
10.1111/bjd.12778. PubMed PMID: 24328907.

5: Ortonne JP, Esposito M, Chimenti S, Kapińska-Mrowiecka M, Grodzińska A, Naldi
L, Frangione V. Betamethasone valerate dressing is non-inferior to
calcipotriol-betamethasone dipropionate ointment in the treatment of patients
with mild-to-moderate chronic plaque psoriasis: results of a randomized
assessor-blinded multicentre trial. J Eur Acad Dermatol Venereol. 2014
Sep;28(9):1226-34. doi: 10.1111/jdv.12270. Epub 2013 Oct 29. PubMed PMID:
24256460; PubMed Central PMCID: PMC4282443.

6: Deo KS, Dash KN, Sharma YK, Virmani NC, Oberai C. Kojic Acid vis-a-vis its
Combinations with Hydroquinone and Betamethasone Valerate in Melasma: A
Randomized, Single Blind, Comparative Study of Efficacy and Safety. Indian J
Dermatol. 2013 Jul;58(4):281-5. doi: 10.4103/0019-5154.113940. PubMed PMID:
23918998; PubMed Central PMCID: PMC3726874.

7: Pratap DV, Philip M, Rao NT, Jerajani HR, Kumar SA, Kuruvila M, Moodahadu LS,
Dhawan S. Evaluation of Efficacy, Safety, and Tolerability of Fixed Dose
Combination (FDC) of Halometasone 0.05% and Fusidic Acid 2% W/W Topical Cream
Versus FDC of Betamethasone Valerate 0.12% and Neomycin Sulphate 0.5% W/W Topical
Cream in the Treatment of Infected Eczematous Dermatosis in Indian Subjects: A
Randomized Open-Label Comparative Phase III Multi-Centric Trial. Indian J
Dermatol. 2013 Mar;58(2):117-23. doi: 10.4103/0019-5154.108041. PubMed PMID:
23716800; PubMed Central PMCID: PMC3657210.

8: Özcan I, Azizoğlu E, Senyiğit T, Özyazici M, Özer Ö. Comparison of PLGA and
lecithin/chitosan nanoparticles for dermal targeting of betamethasone valerate. J
Drug Target. 2013 Jul;21(6):542-50. doi: 10.3109/1061186X.2013.769106. Epub 2013
Feb 8. PubMed PMID: 23390922.

9: Khattak SU, Sheikh D, Ahmad I, Usmanghani K. Kinetics of thermal degradation
of betamethasone valerate and betamethasone dipropionate in different media.
Indian J Pharm Sci. 2012 Mar;74(2):133-40. doi: 10.4103/0250-474X.103845. PubMed
PMID: 23325994; PubMed Central PMCID: PMC3546330.

10: Sookpotarom P, Asawutmangkul C, Srinithiwat B, Leethochawalit S, Vejchapipat
P. Is half strength of 0.05 % betamethasone valerate cream still effective in the
treatment of phimosis in young children? Pediatr Surg Int. 2013 Apr;29(4):393-6.
doi: 10.1007/s00383-012-3253-9. PubMed PMID: 23292538.

11: Uaboonkul T, Nakakes A, Ayuthaya PK. A randomized control study of the
prevention of hyperpigmentation post Q-switched Nd:YAG laser treatment of Hori
nevus using topical fucidic acid plus betamethasone valerate cream versus fucidic
acid cream. J Cosmet Laser Ther. 2012 Jun;14(3):145-9. doi:
10.3109/14764172.2012.682066. PubMed PMID: 22471899.

12: Kuldeep C, Singhal H, Khare AK, Mittal A, Gupta LK, Garg A. Randomized
comparison of topical betamethasone valerate foam, intralesional triamcinolone
acetonide and tacrolimus ointment in management of localized alopecia areata. Int
J Trichology. 2011 Jan;3(1):20-4. doi: 10.4103/0974-7753.82123. PubMed PMID:
21769231; PubMed Central PMCID: PMC3129118.

13: Naldi L, Yawalkar N, Kaszuba A, Ortonne JP, Morelli P, Rovati S, Mautone G.
Efficacy and safety of the Betamethasone valerate 0.1% plaster in
mild-to-moderate chronic plaque psoriasis: a randomized, parallel-group,
active-controlled, phase III study. Am J Clin Dermatol. 2011 Jun 1;12(3):191-201.
doi: 10.2165/11539780-000000000-00000. PubMed PMID: 21284407.

14: Somuramasami J, Wei YC, Soliman EF, Rustum AM. Static headspace gas
chromatographic method for the determination of low and high boiling residual
solvents in Betamethasone valerate. J Pharm Biomed Anal. 2011 Jan 5;54(1):242-7.
doi: 10.1016/j.jpba.2010.08.003. Epub 2010 Aug 13. PubMed PMID: 20828963.

15: Saraceno R, Chiricozzi A, Nisticò SP, Tiberti S, Chimenti S. An occlusive
dressing containing betamethasone valerate 0.1% for the treatment of prurigo
nodularis. J Dermatolog Treat. 2010 Nov;21(6):363-6. doi:
10.3109/09546630903386606. PubMed PMID: 20536273.

16: Vozza A, Di Girolamo F, Montesarchio G, Capuano A, Ascierto PA, Vozza G.
Kerion Celsi favored by the use of a tretinoin+minoxidil+betamethasone valerate
lotion in a 28-year-old woman. G Ital Dermatol Venereol. 2010 Apr;145(2):313-5.
PubMed PMID: 20467404.

17: Thawornchaisit P, Harncharoen K. A comparative study of tar and betamethasone
valerate in chronic plaque psoriasis: a study in Thailand. J Med Assoc Thai. 2007
Oct;90(10):1997-2002. PubMed PMID: 18041415.

18: Xhauflaire-Uhoda E, Thirion L, Piérard-Franchimont C, Piérard GE. Comparative
effect of tacrolimus and betamethasone valerate on the passive sustainable
hydration of the stratum corneum in atopic dermatitis. Dermatology.
2007;214(4):328-32. PubMed PMID: 17460405.

19: Hajheydari Z, Jamshidi M, Akbari J, Mohammadpour R. Combination of topical
garlic gel and betamethasone valerate cream in the treatment of localized
alopecia areata: a double-blind randomized controlled study. Indian J Dermatol
Venereol Leprol. 2007 Jan-Feb;73(1):29-32. PubMed PMID: 17314444.

20: Kitsukawa S, Ito T, Hosoda S, Samejima T, Otsuru N, Matsumoto T, Yamamoto Y,
Noda K, Matsumoto T, Aizawa T. [Early effect of non-surgical treatment using
betamethasone valerate ointment for phimosis in childhood]. Hinyokika Kiyo. 2006
May;52(5):337-41. Japanese. PubMed PMID: 16758721.