Buspirone HCl

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 317360

CAS#: 33386-08-2 (HCl)

Description: Buspirone is an anxiolytic psychotropic drug of the azapirone chemical class. It is primarily used to treat generalized anxiety disorder (GAD). Unlike most drugs predominantly used to treat anxiety, buspirone's pharmacology is not related to benzodiazepines or barbiturates, and so does not carry the risk of physical dependence and withdrawal symptoms for which those drug classes are known.

Chemical Structure

Buspirone HCl
CAS# 33386-08-2 (HCl)

Theoretical Analysis

MedKoo Cat#: 317360
Name: Buspirone HCl
CAS#: 33386-08-2 (HCl)
Chemical Formula: C21H32ClN5O2
Exact Mass:
Molecular Weight: 421.97
Elemental Analysis: C, 59.77; H, 7.64; Cl, 8.40; N, 16.60; O, 7.58

Price and Availability

Size Price Availability Quantity
1.0g USD 190.0 2 Weeks
5.0g USD 480.0 2 Weeks
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Related CAS #: 36505-84-7 (free base)   33386-08-2 (HCl)    

Synonym: Buspirone HCl; Buspirone hydrochloride; Buspirone, Buspar, MJ 9022 1, MJ-9022-1, MJ90221, MJ9022 1, MJ9022-1

IUPAC/Chemical Name: 8-(4-(4-(pyrimidin-2-yl)piperazin-1-yl)butyl)-8-azaspiro[4.5]decane-7,9-dione hydrochloride


InChi Code: InChI=1S/C21H31N5O2.ClH/c27-18-16-21(6-1-2-7-21)17-19(28)26(18)11-4-3-10-24-12-14-25(15-13-24)20-22-8-5-9-23-20;/h5,8-9H,1-4,6-7,10-17H2;1H


Appearance: White crystalline powder.

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 421.97 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Howland RH. Buspirone: Back to the Future. J Psychosoc Nurs Ment Health Serv.
2015 Nov 1;53(11):21-4. doi: 10.3928/02793695-20151022-01. PubMed PMID: 26535760.

2: Kingsberg SA, Clayton AH, Pfaus JG. The Female Sexual Response: Current
Models, Neurobiological Underpinnings and Agents Currently Approved or Under
Investigation for the Treatment of Hypoactive Sexual Desire Disorder. CNS Drugs.
2015 Oct 30. [Epub ahead of print] PubMed PMID: 26519340.

3: Kuchiiwa T, Kuchiiwa S. Evaluation of aggressiveness of female mice using a
semi-automated apparatus for measurement of aggressive biting behavior toward an
inanimate object. J Neurosci Methods. 2015 Oct 17;257:179-184. doi:
10.1016/j.jneumeth.2015.10.005. [Epub ahead of print] PubMed PMID: 26484786.