WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 317360
CAS#: 33386-08-2 (HCl)
Description: Buspirone is an anxiolytic psychotropic drug of the azapirone chemical class. It is primarily used to treat generalized anxiety disorder (GAD). Unlike most drugs predominantly used to treat anxiety, buspirone's pharmacology is not related to benzodiazepines or barbiturates, and so does not carry the risk of physical dependence and withdrawal symptoms for which those drug classes are known.
MedKoo Cat#: 317360
Name: Buspirone HCl
CAS#: 33386-08-2 (HCl)
Chemical Formula: C21H32ClN5O2
Exact Mass:
Molecular Weight: 421.97
Elemental Analysis: C, 59.77; H, 7.64; Cl, 8.40; N, 16.60; O, 7.58
Related CAS #: 36505-84-7 (free base) 33386-08-2 (HCl)
Synonym: Buspirone HCl; Buspirone hydrochloride; Buspirone, Buspar, MJ 9022 1, MJ-9022-1, MJ90221, MJ9022 1, MJ9022-1
IUPAC/Chemical Name: 8-(4-(4-(pyrimidin-2-yl)piperazin-1-yl)butyl)-8-azaspiro[4.5]decane-7,9-dione hydrochloride
InChi Key: RICLFGYGYQXUFH-UHFFFAOYSA-N
InChi Code: InChI=1S/C21H31N5O2.ClH/c27-18-16-21(6-1-2-7-21)17-19(28)26(18)11-4-3-10-24-12-14-25(15-13-24)20-22-8-5-9-23-20;/h5,8-9H,1-4,6-7,10-17H2;1H
SMILES Code: O=C(N(CCCCN1CCN(C2=NC=CC=N2)CC1)C(C3)=O)CC43CCCC4.Cl
Appearance: White crystalline powder.
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 421.97 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Howland RH. Buspirone: Back to the Future. J Psychosoc Nurs Ment Health Serv.
2015 Nov 1;53(11):21-4. doi: 10.3928/02793695-20151022-01. PubMed PMID: 26535760.
2: Kingsberg SA, Clayton AH, Pfaus JG. The Female Sexual Response: Current
Models, Neurobiological Underpinnings and Agents Currently Approved or Under
Investigation for the Treatment of Hypoactive Sexual Desire Disorder. CNS Drugs.
2015 Oct 30. [Epub ahead of print] PubMed PMID: 26519340.
3: Kuchiiwa T, Kuchiiwa S. Evaluation of aggressiveness of female mice using a
semi-automated apparatus for measurement of aggressive biting behavior toward an
inanimate object. J Neurosci Methods. 2015 Oct 17;257:179-184. doi:
10.1016/j.jneumeth.2015.10.005. [Epub ahead of print] PubMed PMID: 26484786.
