Benzthiazide
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 317316

CAS#: 91-33-8

Description: Benzthiazide is a research compound with diuretic and antihypertensive properties used in the treatment of high blood pressure and edema.


Chemical Structure

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Benzthiazide
CAS# 91-33-8

Theoretical Analysis

MedKoo Cat#: 317316
Name: Benzthiazide
CAS#: 91-33-8
Chemical Formula: C15H14ClN3O4S3
Exact Mass: 430.9835
Molecular Weight: 431.94
Elemental Analysis: C, 41.71; H, 3.27; Cl, 8.21; N, 9.73; O, 14.82; S, 22.27

Price and Availability

Size Price Availability Quantity
1.0g USD 350.0 2 weeks
2.0g USD 550.0 2 weeks
5.0g USD 750.0 2 weeks
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Synonym: Benzthiazide; Benzothiazide; Dihydrex; Aquatag; Diucen; Exna; Edemax; Foven; Dytide

IUPAC/Chemical Name: Benzthazide; 3-[(benzylsulfanyl)methyl]-6-chloro-4H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide

InChi Key: NDTSRXAMMQDVSW-UHFFFAOYSA-N

InChi Code: InChI=1S/C15H14ClN3O4S3/c16-11-6-12-14(7-13(11)25(17,20)21)26(22,23)19-15(18-12)9-24-8-10-4-2-1-3-5-10/h1-7H,8-9H2,(H,18,19)(H2,17,20,21)

SMILES Code: O=S(N=C1CSCC2=CC=CC=C2)(C3=CC(S(=O)(N)=O)=C(Cl)C=C3N1)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 431.94 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Adler RA, Costanzo LS, Stauffer ME. Hypercalciuria in hyperprolactinemic rats:
effects of benzthiazide. Metabolism. 1986 Jul;35(7):668-72. PubMed PMID: 3724459.

2: Shah VP, Keys CA, King DM, Prasad VK, Cabana BE. Thiazides XIII: Dissolution
testing: a bioavailability predictor for benzthiazide tablets. Biopharm Drug
Dispos. 1982 Jul-Sep;3(3):283-5. PubMed PMID: 7139068.

3: Meyer MC, Hwang P, Straughn AB, Rotenberg K. HPLC determination of
benzthiazide in biologic material. Biopharm Drug Dispos. 1982 Jan-Mar;3(1):1-9.
PubMed PMID: 7082774.

4: Yajnik VH, Doshi HV, Patel SC, Doshi KJ. Combined treatment with triamterene
and benzthiazide in cases of hypertension. J Assoc Physicians India. 1977
Jan;25(1):31-6. PubMed PMID: 924952.

5: Fazzari FR. Collaborative study of assay for benzthiazide and
hydrochlorothiazide in pharmaceuticals. J Assoc Off Anal Chem. 1972
Jan;55(1):161-2. PubMed PMID: 4666837.

6: Shah CP, Shah BR, Sanghavi NG, Shah JB, Trivedi PM. Treatment of oedema with a
combination of triamterene with benzthiazide. J Assoc Physicians India. 1969
Oct;17(10):605-13. PubMed PMID: 5344774.

7: Thomas J, Thomas E, Desgrez P. [Association of phytic acid and benzthiazide in
renal lithiasis]. Rein Foie. 1966;8:171-85. French. PubMed PMID: 5914037.

8: Gylding-Sabroe JP, Borch Nielsen H. [Triamterene and benzthiazide in long-term
treatment of edemas]. Nord Med. 1965 Nov 25;74(47):1195-8. Danish. PubMed PMID:
5848420.

9: Thomas J, Thomas E, Desgrez P. [Hypocalciuric action of benzthiazide evaluated
on 50 cases of hypercalciuric renal lithiasis. Concomitant study of phosphate,
magnesium and urate elimination and of the behavior of titratable acidity and
urinary pH]. Therapie. 1965 Nov-Dec;20(6):1443-61. French. PubMed PMID: 5855992.

10: Thompson RA, Crowley MF. Trial of a triamterene-benzthiazide combination
(Dytide). Postgrad Med J. 1965 Nov;41(481):706-11. PubMed PMID: 5320489; PubMed
Central PMCID: PMC2483201.

11: EDGE JR, ADISESH LT. COMBINED BENZTHIAZIDE AND TRIAMTERENE FOR RESISTANT
EDEMA. Appl Ther. 1965 Feb;7:117-9. PubMed PMID: 14264860.

12: TOURNIAIRE A, BLUM J, GUYOT R. [EFFECT OF THE MICRONIZED
SPIRONOLACTONE-BENZTHIAZIDE ASSOCIATION ON CONGESTIVE CARDIAC INSUFFICIENCY. TEST
OF CONTINUOUS TREATMENT]. Lyon Med. 1964 Nov 22;212:1159-80. French. PubMed PMID:
14233310.

13: SOULIE P, COLONNA D. [THE BENZTHIAZIDE-TRIAMTERENE COMBINATION. CLINICAL
EXPERIMENTATION IN CARDIOLOGY]. Arch Mal Coeur Vaiss. 1964 Aug;57:942-52. French.
PubMed PMID: 14192889.

14: HOLT MC. USE OF METHOSERPIDINE-BENZTHIAZIDE COMBINATION IN THE TREATMENT OF
ESSENTIAL HYPERTENSION. Br J Clin Pract. 1964 Apr;19:199-204. PubMed PMID:
14272419.

15: WAREMBOURG H, BASIN B. [CLINICAL AND BIOLOGICAL STUDY OF A DIURETIC
PREPARATION COMBINING TRIAMINOPTERIDINE AND BENZTHIAZIDE]. Lille Med. 1964
Mar;37:277-84. French. PubMed PMID: 14141055.

16: DELAHAYE JP, VALLON C, PELLET M, GONIN A. [THERAPEUTIC TRIAL OF TRIAMTERENE
AND TRIAMTERENE-BENZTHIAZIDE IN CARDIOLOGY]. J Med Lyon. 1964 Jan 20;45:185-92.
French. PubMed PMID: 14113141.

17: POTTON F, DESSIMOND JL. [HYPOCALCIURIC EFFECT OF BENZTHIAZIDE]. Lyon Med.
1963 Nov 24;210:1043-72. French. PubMed PMID: 14099113.

18: MIROUZE J, JAFFIOL C. [IMPORTANCE OF BENZTHIAZIDE, AN ORIGINAL SULFONAMIDE
DIURETIC]. Gaz Med Fr. 1963 Sep 25;70:2765-9. French. PubMed PMID: 14121074.

19: GOLASZEWSKI J, HEALY JM. A clinical evaluation of a combination of two oral
diuretics--triamterene and benzthiazide. Br J Dis Chest. 1963 Jan;57:53-8. PubMed
PMID: 13948632.

20: DIEBOLD A, CAPDEVILLE R. [Arterial hypertension. Clinical experimentation
with a new hypotensive comination: 10-methoxydeserpidine-benzthiazide-potassium
chloride]. Presse Med. 1962 Dec 22;70:2703-4. French. PubMed PMID: 14027747.