Bupropion HCl
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MedKoo CAT#: 317359

CAS#: 31677-93-7 (HCl)

Description: Bupropion or bupropion hydrochloride, also known formerly as amfebutamone, is a medication primarily used as an antidepressant and smoking cessation aid. It is one of the most frequently prescribed antidepressants in the United States, although in many English-speaking countries, including the United Kingdom, Australia and New Zealand, this is an off-label use. Chemically, bupropion is in the aminoketone family. Bupropion serves as an atypical antidepressant different from most commonly prescribed antidepressants such as selective serotonin reuptake inhibitors (SSRIs). It is an effective antidepressant on its own, but is also popular as an add-on medication in cases of incomplete response to first-line SSRI antidepressants.


Chemical Structure

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Bupropion HCl
CAS# 31677-93-7 (HCl)

Theoretical Analysis

MedKoo Cat#: 317359
Name: Bupropion HCl
CAS#: 31677-93-7 (HCl)
Chemical Formula: C13H19Cl2NO
Exact Mass: 239.10769
Molecular Weight: 276.201
Elemental Analysis: C, 56.53; H, 6.93; Cl, 25.67; N, 5.07; O, 5.79

Size Price Shipping out time Quantity
1g USD 150 2 Weeks
2g USD 250 2 Weeks
5g USD 450 2 Weeks
10g USD 650 2 Weeks
25g USD 950 2 Weeks
50g USD 1650 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2021-03-09. Prices are subject to change without notice.

Bupropion hydrochloride, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received. Delivery time: overnight (USA/Canada); 3-5 days (worldwide). Shipping fee: from $30.00 (USA); from $45.00 (Canada); from $70.00 (international).

Related CAS #: 31677-93-7 (HCl)   34841-39-9 (free base)  

Synonym: Bupropion, Wellbutrin, Zyban; BW 323; BW-323; BW323. NSC 315851.

IUPAC/Chemical Name: 2-(tert-butylamino)-1-(3-chlorophenyl)propan-1-one hydrochloride

InChi Key: HEYVINCGKDONRU-UHFFFAOYSA-N

InChi Code: InChI=1S/C13H18ClNO.ClH/c1-9(15-13(2,3)4)12(16)10-6-5-7-11(14)8-10;/h5-9,15H,1-4H3;1H

SMILES Code: CC(NC(C)(C)C)C(C1=CC=CC(Cl)=C1)=O.[H]Cl

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001

Handling Instructions:

Preparing Stock Solutions

The following data is based on the product molecular weight 276.201 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Teply RM, Packard KA, White ND, Hilleman DE, DiNicolantonio JJ. Treatment of
Depression in Patients with Concomitant Cardiac Disease. Prog Cardiovasc Dis.
2015 Nov 9. pii: S0033-0620(15)30022-0. doi: 10.1016/j.pcad.2015.11.003. [Epub
ahead of print] Review. PubMed PMID: 26562328.

2: Liu YW, Chang C, Chen TY, Chang HA, Kao YC, Tzeng NS. Refractory depression
with catatonic features was remitted with administration of intravenous dopamine
and consequent bupropion as maintenance treatment. Aust N Z J Psychiatry. 2015
Nov 11. pii: 0004867415616697. [Epub ahead of print] PubMed PMID: 26560841.

3: Gartlehner G, Nussbaumer B, Gaynes BN, Forneris CA, Morgan LC,
Kaminski-Hartenthaler A, Greenblatt A, Wipplinger J, Lux LJ, Sonis JH, Hofmann J,
Van Noord MG, Winkler D. Second-generation antidepressants for preventing
seasonal affective disorder in adults. Cochrane Database Syst Rev. 2015 Nov
8;11:CD011268. [Epub ahead of print] Review. PubMed PMID: 26558418.