Bupranolol HCl

WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 317357

CAS#: 15148-80-8 (HCl)

Description: Bupranolol is a non-selective beta blocker without intrinsic sympathomimetic activity (ISA), but with strong membrane stabilizing activity. Its potency is similar to propranolol. Bupranolol is quickly and completely absorbed from the gut. Over 90% undergo first-pass metabolism. Bupranolol has a plasma half life of about two to four hours, with levels never reaching 1 µg/l in therapeutic doses. The main metabolite is carboxybupranolol, 4-chloro-3-[3-(1,1-dimethylethylamino)-2-hydroxy-propyloxy]benzoic acid – that is, the methyl group at the benzene ring is oxidized to a carboxyl group –, of which 88% are eliminated renally within 24 hours.

Chemical Structure

Bupranolol HCl

CAS# 15148-80-8 (HCl)

Handing Instruction

Theoretical Analysis

MedKoo Cat#: 317357
Name: Bupranolol HCl
CAS#: 15148-80-8 (HCl)
Chemical Formula: C14H23Cl2NO2
Exact Mass: 271.13391
Molecular Weight: 308.243
Elemental Analysis: C, 54.55; H, 7.52; Cl, 23.00; N, 4.54; O, 10.38

Size	Price	Shipping out time	Quantity
Inquire bulk and customized quantity Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Pricing updated 2021-03-07. Prices are subject to change without notice.

Bupranolol HCl, purity > 98%, is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.

Related CAS #: 15148-80-8 (HCl) 23284-25-5 (free base)

Synonym: KL255, KL 255, KL-255, Bupranolol; Bupranolol Hdrochloride

IUPAC/Chemical Name: 1-(tert-butylamino)-3-(2-chloro-5-methylphenoxy)propan-2-ol hydrochloride

InChi Key: WJUUZHQWGKSLIJ-UHFFFAOYSA-N

InChi Code: InChI=1S/C14H22ClNO2.ClH/c1-10-5-6-12(15)13(7-10)18-9-11(17)8-16-14(2,3)4;/h5-7,11,16-17H,8-9H2,1-4H3;1H

SMILES Code: OC(COC1=CC(C)=CC=C1Cl)CNC(C)(C)C.[H]Cl

Appearance:

Solid powder

Purity:

>98% (or refer to the Certificate of Analysis)

Shipping Condition:

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:

Soluble in DMSO, not in water

Shelf Life:

>2 years if stored properly

Drug Formulation:

This drug may be formulated in DMSO

Stock Solution Storage:

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:

2934.99.9001

Handling Instructions:

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 308.243 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Reconstitution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

1: Martin LJ, Piltonen MH, Gauthier J, Convertino M, Acland EL, Dokholyan NV,
Mogil JS, Diatchenko L, Maixner W. Differences in the antinociceptive effects and
binding properties of propranolol and bupranolol enantiomers. J Pain. 2015 Oct 5.
pii: S1526-5900(15)00877-9. doi: 10.1016/j.jpain.2015.09.004. [Epub ahead of
print] PubMed PMID: 26456674.

2: Ma Y, Zhang H, Rahman ZU, Wang W, Li X, Chen H, Chen X. Sensitive
enantioanalysis of β-blockers via field-amplified sample injection combined with
water removal in microemulsion electrokinetic chromatography. Electrophoresis.
2014 Oct;35(19):2772-7. doi: 10.1002/elps.201400008. Epub 2014 Jun 20. PubMed
PMID: 24798241.

Your view history

Bupranolol HCl

10mg / Not available