WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 317357
CAS#: 15148-80-8 (HCl)
Description: Bupranolol is a non-selective beta blocker without intrinsic sympathomimetic activity (ISA), but with strong membrane stabilizing activity. Its potency is similar to propranolol. Bupranolol is quickly and completely absorbed from the gut. Over 90% undergo first-pass metabolism. Bupranolol has a plasma half life of about two to four hours, with levels never reaching 1 µg/l in therapeutic doses. The main metabolite is carboxybupranolol, 4-chloro-3-[3-(1,1-dimethylethylamino)-2-hydroxy-propyloxy]benzoic acid – that is, the methyl group at the benzene ring is oxidized to a carboxyl group –, of which 88% are eliminated renally within 24 hours.
MedKoo Cat#: 317357
Name: Bupranolol HCl
CAS#: 15148-80-8 (HCl)
Chemical Formula: C14H23Cl2NO2
Exact Mass: 271.13391
Molecular Weight: 308.243
Elemental Analysis: C, 54.55; H, 7.52; Cl, 23.00; N, 4.54; O, 10.38
Bupranolol HCl, purity > 98%, is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to firstname.lastname@example.org to inquire quote.
Related CAS #: 15148-80-8 (HCl) 23284-25-5 (free base)
Synonym: KL255, KL 255, KL-255, Bupranolol; Bupranolol Hdrochloride
IUPAC/Chemical Name: 1-(tert-butylamino)-3-(2-chloro-5-methylphenoxy)propan-2-ol hydrochloride
InChi Key: WJUUZHQWGKSLIJ-UHFFFAOYSA-N
InChi Code: InChI=1S/C14H22ClNO2.ClH/c1-10-5-6-12(15)13(7-10)18-9-11(17)8-16-14(2,3)4;/h5-7,11,16-17H,8-9H2,1-4H3;1H
SMILES Code: OC(COC1=CC(C)=CC=C1Cl)CNC(C)(C)C.[H]Cl
The following data is based on the product molecular weight 308.243 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Martin LJ, Piltonen MH, Gauthier J, Convertino M, Acland EL, Dokholyan NV,
Mogil JS, Diatchenko L, Maixner W. Differences in the antinociceptive effects and
binding properties of propranolol and bupranolol enantiomers. J Pain. 2015 Oct 5.
pii: S1526-5900(15)00877-9. doi: 10.1016/j.jpain.2015.09.004. [Epub ahead of
print] PubMed PMID: 26456674.
2: Ma Y, Zhang H, Rahman ZU, Wang W, Li X, Chen H, Chen X. Sensitive
enantioanalysis of β-blockers via field-amplified sample injection combined with
water removal in microemulsion electrokinetic chromatography. Electrophoresis.
2014 Oct;35(19):2772-7. doi: 10.1002/elps.201400008. Epub 2014 Jun 20. PubMed