Bupivacaine HCl
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MedKoo CAT#: 317356

CAS#: 18010-40-7 (HCl)

Description: Bupivacaine, is a medication used to freeze tissue in a specific area. It is used by injecting it into the area, around a nerve that supplies the area, or into the spinal canal's epidural space. It is available mixed with a small amount of epinephrine to make it last longer. It typically begins working within 15 minutes and lasts for 2 to 8 hours. Bupivacaine binds to the intracellular portion of voltage-gated sodium channels and blocks sodium influx into nerve cells, which prevents depolarization. Without depolarization, no initiation or conduction of a pain signal can occur.


Chemical Structure

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Bupivacaine HCl
CAS# 18010-40-7 (HCl)

Theoretical Analysis

MedKoo Cat#: 317356
Name: Bupivacaine HCl
CAS#: 18010-40-7 (HCl)
Chemical Formula: C18H29ClN2O
Exact Mass: 288.22016
Molecular Weight: 324.893
Elemental Analysis: C, 66.54; H, 9.00; Cl, 10.91; N, 8.62; O, 4.92

Size Price Shipping out time Quantity
1g USD 150 2 Weeks
2g USD 250 2 Weeks
5g USD 450 2 Weeks
10g USD 650 2 Weeks
25g USD 950 2 Weeks
50g USD 1650 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2021-03-08. Prices are subject to change without notice.

Bupivacaine HCl, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.

Related CAS #: 18010-40-7 (HCl)   2180-92-9 (free base)  

Synonym: Bupivacaine, Marcaine; AH-250; HSDB 7790; SKY 0402; SKY0402, Win 11318; AH 250; AH250; HSDB7790; HSDB-7790; SKY-0402; Win-11318; Win11318

IUPAC/Chemical Name: 1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide hydrochloride

InChi Key: SIEYLFHKZGLBNX-UHFFFAOYSA-N

InChi Code: InChI=1S/C18H28N2O.ClH/c1-4-5-12-20-13-7-6-11-16(20)18(21)19-17-14(2)9-8-10-15(17)3;/h8-10,16H,4-7,11-13H2,1-3H3,(H,19,21);1H

SMILES Code: O=C(C1N(CCCC)CCCC1)NC2=C(C)C=CC=C2C

Appearance:
White crystalline powder.

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001

Handling Instructions:

Preparing Stock Solutions

The following data is based on the product molecular weight 324.893 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Li H, Wang B, Wang F, Xu Z, Zhou N, Wang X, Wang K. Effects of epidural
analgesia with different concentrations of bupivacaine plus fentanyl on pain in
patients undergoing thoracic surgery. Int J Clin Exp Med. 2015 Aug
15;8(8):14123-6. eCollection 2015. PubMed PMID: 26550381; PubMed Central PMCID:
PMC4613066.

2: Lin S, Hua J, Xu B, Yang T, He Z, Xu C, Meng H, Zhou B, Song Z. Comparison of
bupivacaine and parecoxib for postoperative pain relief after laparoscopic
cholecystectomy: a randomized controlled trial. Int J Clin Exp Med. 2015 Aug
15;8(8):13824-9. eCollection 2015. PubMed PMID: 26550332; PubMed Central PMCID:
PMC4613017.