Trovafloxacin mesylate
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MedKoo CAT#: 318961

CAS#: 147059-75-4 (mesylate)

Description: Trovafloxacin was a broad spectrum antibiotic that inhibits the uncoiling of supercoiled DNA in various bacteria by blocking the activity of DNA gyrase and topoisomerase IV. It was withdrawn from the market due to the risk of hepatotoxicity. It had better gram-positive bacterial coverage and less gram-negative coverage than the previous fluoroquinolones.


Chemical Structure

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Trovafloxacin mesylate
CAS# 147059-75-4 (mesylate)

Theoretical Analysis

MedKoo Cat#: 318961
Name: Trovafloxacin mesylate
CAS#: 147059-75-4 (mesylate)
Chemical Formula: C21H19F3N4O6S
Exact Mass:
Molecular Weight: 512.46021
Elemental Analysis: C, 49.22; H, 3.74; F, 11.12; N, 10.93; O, 18.73; S, 6.26

Size Price Shipping out time Quantity
10mg USD 350 2 Weeks
25mg USD 650 2 Weeks
50mg USD 1150 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2021-03-03. Prices are subject to change without notice.

Trovafloxacin mesylate, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.

Related CAS #: 147059-75-4 (mesylate)   147059-72-1 (free base)    

Synonym: CP-99219; CP 99219; CP99219; CP 99,219; CP 99219; CP-99,219; Trovafloxacin mesylate; Band name: Trovan;Turvel.

IUPAC/Chemical Name: 7-[(1S,5R)-6-amino-3-azabicyclo[3.1.0]hexan-3-yl]-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylic acid methanesulfonic acid

InChi Key: DYNZICQDCVYXFW-GIPYJWDTSA-N

InChi Code: InChI=1S/C20H15F3N4O3.CH4O3S/c21-8-1-2-15(13(22)3-8)27-7-12(20(29)30)17(28)9-4-14(23)19(25-18(9)27)26-5-10-11(6-26)16(10)24;1-5(2,3)4/h1-4,7,10-11,16H,5-6,24H2,(H,29,30);1H3,(H,2,3,4)/t10-,11+,16?;

SMILES Code: O=C(C1=CN(C2=CC=C(F)C=C2F)C3=NC(N4C[C@@]5([H])C(N)[C@@]5([H])C4)=C(F)C=C3C1=O)O.CS(=O)(O)=O

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001

Handling Instructions:

Preparing Stock Solutions

The following data is based on the product molecular weight 512.46021 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Shaw PJ, Ganey PE, Roth RA. Idiosyncratic drug-induced liver injury and the role of inflammatory stress with an emphasis on an animal model of trovafloxacin hepatotoxicity. Toxicol Sci. 2010 Nov;118(1):7-18. doi: 10.1093/toxsci/kfq168. Epub 2010 Jun 10. Review. PubMed PMID: 20538741; PubMed Central PMCID: PMC2955207.

2: Mandell LA. [The role of trovafloxacin in the treatment of nosocomial pneumonia]. Medicina (B Aires). 1999;59 Suppl 1:39-46. Review. Spanish. PubMed PMID: 10436553.

3: Azanza JR, Ollero D, Sádaba B, García Quetglas E. [Trovafloxacin]. Rev Med Univ Navarra. 1999 Jan-Mar;43(1):45-57. Review. Spanish. PubMed PMID: 10386346.

4: Garau J. [Is trovafloxacin an antibiotic exclusively for the treatment of respiratory infections?]. Enferm Infecc Microbiol Clin. 1998 Dec;16 Suppl 2:43-6; discussion 47-52. Review. Spanish. PubMed PMID: 10344098.

5: Frías J, de los Angeles Gálvez M. [Pharmacokinetics and safety of trovafloxacin]. Enferm Infecc Microbiol Clin. 1998 Dec;16 Suppl 2:36-42; discussion 47-52. Review. Spanish. PubMed PMID: 10344097.

6: Alghasham AA, Nahata MC. Trovafloxacin: a new fluoroquinolone. Ann Pharmacother. 1999 Jan;33(1):48-60. Review. PubMed PMID: 9972385.

7: Garey KW, Amsden GW. Trovafloxacin: an overview. Pharmacotherapy. 1999 Jan;19(1):21-34. Review. PubMed PMID: 9917076.

8: Pechère JC, Gootz TD. Bacteriological activity of trovafloxacin, a new quinolone, against respiratory tract pathogens. Eur J Clin Microbiol Infect Dis. 1998 Jun;17(6):405-12. Review. PubMed PMID: 9758283.

9: McNabb J, Nicolau D, Quintiliani R, Nightingale C. Trovafloxacin: fourth generation fluoroquinolone. Conn Med. 1998 Aug;62(8):483-7. Review. PubMed PMID: 9753805.

10: Ernst ME, Ernst EJ, Klepser ME. Levofloxacin and trovafloxacin: the next generation of fluoroquinolones? Am J Health Syst Pharm. 1997 Nov 15;54(22):2569-84. Review. PubMed PMID: 9397218.

11: Haria M, Lamb HM. Trovafloxacin. Drugs. 1997 Sep;54(3):435-45; discussion 446. Review. PubMed PMID: 9279505.

12: Brighty KE, Gootz TD. The chemistry and biological profile of trovafloxacin. J Antimicrob Chemother. 1997 Jun;39 Suppl B:1-14. Review. PubMed PMID: 9222064.

13: Goldstein EJ. Possible role for the new fluoroquinolones (levofloxacin, grepafloxacin, trovafloxacin, clinafloxacin, sparfloxacin, and DU-6859a) in the treatment of anaerobic infections: review of current information on efficacy and safety. Clin Infect Dis. 1996 Dec;23 Suppl 1:S25-30. Review. PubMed PMID: 8953103.



Additional Information

Related CAS#
CAS#147059-75-4 ( Trovafloxacin mesylate)
CAS#147059-72-1 ( Trovafloxacin free base).