WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 318960
Description: Trospium chloride is a muscarinic antagonist. Trospium chloride antagonizes the effect of acetylcholine on muscarinic receptors in cholinergically innervated organs including the bladder. Its parasympatholytic action reduces the tonus of smooth muscle in the bladder. Receptor assays showed that trospium chloride has negligible affinity for nicotinic receptors as compared to muscarinic receptors at concentrations obtained from therapeutic doses.
MedKoo Cat#: 318960
Name: Trospium chloride
Chemical Formula: C25H30ClNO3
Molecular Weight: 427.969
Elemental Analysis: C, 70.16; H, 7.07; Cl, 8.28; N, 3.27; O, 11.22
Synonym: IP631; IP-631; IP 631; Trospium chloride, brand name Sanctura; Tropez OD; Trosec; Regurin; Flotros; Spasmex; Spasmoly.
IUPAC/Chemical Name: (1R,3s,5S)-3-(2-hydroxy-2,2-diphenylacetoxy)spiro[bicyclo[3.2.1]octane-8,1'-pyrrolidin]-8-ium chloride
SMILES Code: O=C(C(C1=CC=CC=C1)(O)C2=CC=CC=C2)O[C@@H]3C[C@H]([N+]45CCCC4)CC[C@H]5C3.[Cl-]
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 427.969 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Chapple C. New once-daily formulation for trospium in overactive bladder. Int J Clin Pract. 2010 Oct;64(11):1535-40. doi: 10.1111/j.1742-1241.2010.02493.x. Review. PubMed PMID: 20846201.
2: Biastre K, Burnakis T. Trospium chloride treatment of overactive bladder. Ann Pharmacother. 2009 Feb;43(2):283-95. doi: 10.1345/aph.1L160. Epub 2009 Feb 3. Review. PubMed PMID: 19193592.
3: Staskin DR. Trospium chloride: Distinct among other anticholinergic agents available for the treatment of overactive bladder. Urol Clin North Am. 2006 Nov;33(4):465-73, viii. Review. PubMed PMID: 17011382.
4: Madersbacher H, Rovner E. Trospium chloride: the European experience. Expert Opin Pharmacother. 2006 Jul;7(10):1373-80. Review. PubMed PMID: 16805722.
5: Zinner NR. Trospium chloride: an anticholinergic quaternary ammonium compound for the treatment of overactive bladder. Expert Opin Pharmacother. 2005 Jul;6(8):1409-20. Review. PubMed PMID: 16013990.
6: Singh-Franco D, Machado C, Tuteja S, Zapantis A. Trospium chloride for the treatment of overactive bladder with urge incontinence. Clin Ther. 2005 May;27(5):511-30. Review. PubMed PMID: 15978301.
7: Doroshyenko O, Jetter A, Odenthal KP, Fuhr U. Clinical pharmacokinetics of trospium chloride. Clin Pharmacokinet. 2005;44(7):701-20. Review. PubMed PMID: 15966754.
8: Rovner ES. Trospium chloride in the management of overactive bladder. Drugs. 2004;64(21):2433-46. Review. PubMed PMID: 15482001.
9: Kershen RT, Hsieh M. Preview of new drugs for overactive bladder and incontinence: darifenacin, solifenacin, trospium, and duloxetine. Curr Urol Rep. 2004 Oct;5(5):359-67. Review. PubMed PMID: 15461912.
10: Pak RW, Petrou SP, Staskin DR. Trospium chloride: a quaternary amine with unique pharmacologic properties. Curr Urol Rep. 2003 Dec;4(6):436-40. Review. PubMed PMID: 14622495.
11: Höfner K, Oelke M, Machtens S, Grünewald V. Trospium chloride--an effective drug in the treatment of overactive bladder and detrusor hyperreflexia. World J Urol. 2001 Nov;19(5):336-43. Review. PubMed PMID: 11760782.
12: Füsgen I, Hauri D. Trospium chloride: an effective option for medical treatment of bladder overactivity. Int J Clin Pharmacol Ther. 2000 May;38(5):223-34. Review. PubMed PMID: 10839466.