Tropicamide
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MedKoo CAT#: 318959

CAS#: 1508-75-4

Description: Tropicamide is an antimuscarinic drug that produces short acting mydriasis (dilation of the pupil) and cycloplegia when applied as eye drops. It is used to allow better examination of the lens, vitreous humor, and retina. Due to its relatively short duration of effect (4–8 hours), it is typically used during eye examinations such as the dilated fundus examination, but it may also be used before or after eye surgery. Cycloplegic drops are often also used to treat anterior uveitis, decreasing risk of posterior synechiae and decreasing inflammation in the anterior chamber of the eye.


Chemical Structure

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Tropicamide
CAS# 1508-75-4

Theoretical Analysis

MedKoo Cat#: 318959
Name: Tropicamide
CAS#: 1508-75-4
Chemical Formula: C17H20N2O2
Exact Mass: 284.15248
Molecular Weight: 284.359
Elemental Analysis: C, 71.81; H, 7.09; N, 9.85; O, 11.25

Size Price Shipping out time Quantity
1g USD 150 2 Weeks
2g USD 250 2 Weeks
5g USD 450 2 Weeks
10g USD 750 2 Weeks
20g USD 1250 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2021-03-01. Prices are subject to change without notice.

Tropicamide, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received. Delivery time: overnight (USA/Canada); 3-5 days (worldwide).

Synonym: Tropicamide, Mydral; Mydriafair; Mydriaticum; Mydrum.

IUPAC/Chemical Name: N-ethyl-3-hydroxy-2-phenyl-N-(pyridin-4-ylmethyl)propanamide

InChi Key: BGDKAVGWHJFAGW-UHFFFAOYSA-N

InChi Code: InChI=1S/C17H20N2O2/c1-2-19(12-14-8-10-18-11-9-14)17(21)16(13-20)15-6-4-3-5-7-15/h3-11,16,20H,2,12-13H2,1H3

SMILES Code: O=C(N(CC)CC1=CC=NC=C1)C(C2=CC=CC=C2)CO

Appearance:
White to off-white crystalline powder.

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001

Handling Instructions:

Preparing Stock Solutions

The following data is based on the product molecular weight 284.359 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Yuan Y, Zhang Z, Zhu J, He X, Du E, Jiang K, Zheng W, Ke B. Responses of the Ocular Anterior Segment and Refraction to 0.5% Tropicamide in Chinese School-Aged Children of Myopia, Emmetropia, and Hyperopia. J Ophthalmol. 2015;2015:612728. doi: 10.1155/2015/612728. Epub 2015 Sep 20. PubMed PMID: 26457196; PubMed Central PMCID: PMC4592723.

2: Hatzav M, Bdolah-Abram T, Ofri R. Interaction with therapeutic soft contact lenses affects the intraocular efficacy of tropicamide and latanoprost in dogs. J Vet Pharmacol Ther. 2015 Sep 28. doi: 10.1111/jvp.12263. [Epub ahead of print] PubMed PMID: 26411631.

3: Selk Ghaffari M, Javadzadeh R, Rajaei SM. Effects of two concentrations of topical tropicamide on the Schirmer tear test in clinically normal cats. J Feline Med Surg. 2015 Aug 27. pii: 1098612X15602524. [Epub ahead of print] PubMed PMID: 26316517.

4: Bersani FS, Imperatori C, Prilutskaya M, Kuliev R, Corazza O. Injecting eye-drops: a mini-review on the non-clinical use of tropicamide. Hum Psychopharmacol. 2015 Jul;30(4):262-4. doi: 10.1002/hup.2481. PubMed PMID: 26216560.

5: Luo S, Wan Z, Yin X, Ye Z, Lu Y. Comparison of the mydriatic effects of mydrin-P and compound tropicamide in the screening of retinopathy of prematurity. Eye Sci. 2014 Dec;29(4):219-22. PubMed PMID: 26016074.

6: Ka AM, De Medeiros ME, Sow AS, Ndiaye PA, Weladji C, Diallo HM, Wane AM, Diagne JP, Kane A, Ndiaye JM, Ndoye Roth PA, Ba EA, Ndiaye MR. [Objective refraction in black children: cyclopentolate and tropicamide combination, a reliable alternative to atropine?]. J Fr Ophtalmol. 2014 Nov;37(9):689-94. doi: 10.1016/j.jfo.2014.05.005. Epub 2014 Sep 6. French. PubMed PMID: 25199485.

7: Bozkurt M, Karabulut V, Evren C, Seker M, Kan H. Intravenous Abuse of Tropicamide in Opioid Use Disorder: Presentation of 2 Cases. Subst Abus. 2015;36(2):170-3. doi: 10.1080/08897077.2014.924465. Epub 2014 Jun 3. PubMed PMID: 24892477.

8: Kovalenko NY, Matsievskii DD, Reshetnyak VK. Effect of selective blockade of M4 cholinoreceptors by tropicamide on blood supply in brain, splanchnic azygous organs, and hindlimbs in intact rats. Bull Exp Biol Med. 2014 Apr;156(6):740-2. doi: 10.1007/s10517-014-2437-9. Epub 2014 May 3. PubMed PMID: 24824684.

9: Haroun-Díaz E, Ruíz-García M, De Luxán de la Lastra S, Pastor-Vargas C, De las Heras M, Sastre Domínguez J, Cuesta-Herranz J. Contact dermatitis to both tropicamide and phenylephrine eye drops. Dermatitis. 2014 May-Jun;25(3):149-50. doi: 10.1097/DER.0000000000000043. PubMed PMID: 24819290.

10: Ogun OA, Oliver JW, Ashaye AO, Ajayi BG. Evaluating the potentiating effect of amethocaine on tropicamide-induced mydriasis in darkly pigmented irides, using infrared pupillometry. Ophthalmol Eye Dis. 2014 Apr 8;6:13-9. doi: 10.4137/OED.S13991. eCollection 2014. PubMed PMID: 24812528; PubMed Central PMCID: PMC4001628.

11: Oltulu R, Satirtav G, Altunkaya O, Bitirgen G, Okka M. Effect of mydriasis induced by topical 0.5% tropicamide instillation on the corneal biomechanical properties in healthy individuals measured by ocular response analyzer. Cutan Ocul Toxicol. 2015 Mar;34(1):35-7. doi: 10.3109/15569527.2014.883404. Epub 2014 Mar 31. PubMed PMID: 24678749.

12: Zhu X, Chen M, Dai J, Lu Y. The effect of 0.5% tropicamide/0.5% phenylephrine mixed eye drop in Chinese adults with myopia and its inter-eye difference in refractive outcomes. Curr Med Res Opin. 2014 Mar;30(3):481-7. doi: 10.1185/03007995.2013.861348. Epub 2013 Nov 15. PubMed PMID: 24215472.

13: Yu X, Liao Z, Yao Q, Liu H, Li X, Yi P. The investigation of the interaction between Tropicamide and bovine serum albumin by spectroscopic methods. Spectrochim Acta A Mol Biomol Spectrosc. 2014 Jan 24;118:331-6. doi: 10.1016/j.saa.2013.08.103. Epub 2013 Aug 31. PubMed PMID: 24056312.

14: Bersani FS, Corazza O, Simonato P, Mylokosta A, Levari E, Lovaste R, Schifano F. Drops of madness? Recreational misuse of tropicamide collyrium; early warning alerts from Russia and Italy. Gen Hosp Psychiatry. 2013 Sep-Oct;35(5):571-3. doi: 10.1016/j.genhosppsych.2013.04.013. Epub 2013 May 23. PubMed PMID: 23706777.

15: Spagnolo PA, Badiani A, Nencini P. Polydrug abuse by intravenous use of heroin and tropicamide-containing eyedrops. Clin Neuropharmacol. 2013 May-Jun;36(3):100-1. doi: 10.1097/WNF.0b013e31828da20e. PubMed PMID: 23673915.

16: McMullen RJ Jr, Davidson MG, Gilger BC. The effect of 1% tropicamide-induced mydriasis and cycloplegia on spherical refraction of the adult horse. Vet Ophthalmol. 2014 Mar;17(2):120-5. doi: 10.1111/vop.12055. Epub 2013 May 6. PubMed PMID: 23647634.

17: Harazny JM, Schmieder RE, Welzenbach J, Michelson G. Local application of tropicamide 0.5% reduces retinal capillary blood flow. Blood Press. 2013 Dec;22(6):371-6. doi: 10.3109/08037051.2013.782956. Epub 2013 Apr 18. PubMed PMID: 23597124.

18: Dilbaghi N, Kaur H, Ahuja M, Kumar S. Evaluation of tropicamide-loaded tamarind seed xyloglucan nanoaggregates for ophthalmic delivery. Carbohydr Polym. 2013 Apr 15;94(1):286-91. doi: 10.1016/j.carbpol.2013.01.054. Epub 2013 Jan 25. PubMed PMID: 23544540.

19: Palamar M, Alkan Z, Egrilmez S, Yagci A. Influences of tropicamide on anterior segment parameters with Pentacam in healthy individuals. J Ocul Pharmacol Ther. 2013 Apr;29(3):349-52. doi: 10.1089/jop.2012.0145. Epub 2012 Oct 12. PubMed PMID: 23061415.

20: Vandewalle E, Abegão Pinto L, Olafsdottir OB, Stalmans I. Phenylephrine 5% added to tropicamide 0.5% eye drops does not influence retinal oxygen saturation values or retinal vessel diameter in glaucoma patients. Acta Ophthalmol. 2013 Dec;91(8):733-7. doi: 10.1111/j.1755-3768.2012.02545.x. Epub 2012 Sep 23. PubMed PMID: 22998076.