Triprolidine HCl
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MedKoo CAT#: 318958

CAS#: 6138-79-0 (HCl)

Description: Triprolidine is an over-the-counter antihistamine with anticholinergic properties. It is used to combat the symptoms associated with allergies and is sometimes combined with other cold medications designed to provide general relief for flu-like symptoms. Like many antihistamines, the most common side effect is drowsiness. Triprolidine is a quick acting drug that can clear congestion and stop runny noses in 15–30 minutes. .


Chemical Structure

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Triprolidine HCl
CAS# 6138-79-0 (HCl)

Theoretical Analysis

MedKoo Cat#: 318958
Name: Triprolidine HCl
CAS#: 6138-79-0 (HCl)
Chemical Formula: C19H23ClN2
Exact Mass: 0.00
Molecular Weight: 314.857
Elemental Analysis: C, 72.48; H, 7.36; Cl, 11.26; N, 8.90

Price and Availability

Size Price Availability Quantity
1g USD 190
2g USD 350
5g USD 550
10g USD 850
20g USD 1250
50g USD 1850
100g USD 2850
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Related CAS #: 6138-79-0 (HCl)   486-12-4 (free base)    

Synonym: Triprolidine HCl; Actidilat; Pro-Actidil; Pro-Entra; Venen; Entra; Actidilon.

IUPAC/Chemical Name: 2-[(E)-1-(4-methylphenyl)-3-pyrrolidin-1-ylprop-1-enyl]pyridine hydrochloride

InChi Key: WYUYEJNGHIOFOC-NWBUNABESA-N

InChi Code: InChI=1S/C19H22N2.ClH/c1-16-7-9-17(10-8-16)18(19-6-2-3-12-20-19)11-15-21-13-4-5-14-21;/h2-3,6-12H,4-5,13-15H2,1H3;1H/b18-11+;

SMILES Code: CC1=CC=C(/C(C2=NC=CC=C2)=C\CN3CCCC3)C=C1.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info: Related CAS# CAS# 6138-79-0 ( TriprolidineHCl salt); CAS#486-12-4 ( Triprolidine free base)

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 314.86 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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19: Stanley N, Alford CA, Rombaut NE, Hindmarch I. Comparison of the effects of astemizole/pseudoephedrine and triprolidine/pseudoephedrine on CNS activity and psychomotor function. Int Clin Psychopharmacol. 1996 Mar;11(1):31-6. PubMed PMID: 8732311.

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