Triprolidine HCl

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 318958

CAS#: 6138-79-0 (HCl)

Description: Triprolidine is an over-the-counter antihistamine with anticholinergic properties. It is used to combat the symptoms associated with allergies and is sometimes combined with other cold medications designed to provide general relief for flu-like symptoms. Like many antihistamines, the most common side effect is drowsiness. Triprolidine is a quick acting drug that can clear congestion and stop runny noses in 15–30 minutes. .

Chemical Structure

Triprolidine HCl
CAS# 6138-79-0 (HCl)

Theoretical Analysis

MedKoo Cat#: 318958
Name: Triprolidine HCl
CAS#: 6138-79-0 (HCl)
Chemical Formula: C19H23ClN2
Exact Mass:
Molecular Weight: 314.857
Elemental Analysis: C, 72.48; H, 7.36; Cl, 11.26; N, 8.90

Price and Availability

Size Price Availability Quantity
1.0g USD 190.0 2 Weeks
2.0g USD 350.0 2 Weeks
5.0g USD 550.0 2 Weeks
10.0g USD 850.0 2 Weeks
20.0g USD 1250.0 2 Weeks
50.0g USD 1850.0 2 Weeks
100.0g USD 2850.0 2 Weeks
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Related CAS #: 6138-79-0 (HCl)   486-12-4 (free base)    

Synonym: Triprolidine HCl; Actidilat; Pro-Actidil; Pro-Entra; Venen; Entra; Actidilon.

IUPAC/Chemical Name: 2-[(E)-1-(4-methylphenyl)-3-pyrrolidin-1-ylprop-1-enyl]pyridine hydrochloride


InChi Code: InChI=1S/C19H22N2.ClH/c1-16-7-9-17(10-8-16)18(19-6-2-3-12-20-19)11-15-21-13-4-5-14-21;/h2-3,6-12H,4-5,13-15H2,1H3;1H/b18-11+;


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 314.857 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Xuan X, Huang L, Pan X, Li N. [Simultaneous determination of five cold medicine ingredients in paracetamol triprolidine hydrochloride and pseudoephedrine hydrochloride tablets by pH/organic solvent double-gradient high performance liquid chromatography]. Se Pu. 2013 Feb;31(2):133-8. Chinese. PubMed PMID: 23697177.

2: Dev R, Kumar A, Pathak K. Solubility-modulated asymmetric membrane tablets of triprolidine hydrochloride: statistical optimization and evaluation. AAPS PharmSciTech. 2012 Mar;13(1):174-83. doi: 10.1208/s12249-011-9738-3. Epub 2011 Dec 20. PubMed PMID: 22183255; PubMed Central PMCID: PMC3299447.

3: Sandhya B, Hegde AH, Kalanur SS, Katrahalli U, Seetharamappa J. Interaction of triprolidine hydrochloride with serum albumins: thermodynamic and binding characteristics, and influence of site probes. J Pharm Biomed Anal. 2011 Apr 5;54(5):1180-6. doi: 10.1016/j.jpba.2010.12.012. Epub 2010 Dec 16. PubMed PMID: 21215548.

4: Manassra A, Khamis M, El-Dakiky M, Abdel-Qader Z, Al-Rimawi F. Simultaneous HPLC analysis of pseudophedrine hydrochloride, codeine phosphate, and triprolidine hydrochloride in liquid dosage forms. J Pharm Biomed Anal. 2010 Mar 11;51(4):991-3. doi: 10.1016/j.jpba.2009.10.024. Epub 2009 Nov 10. PubMed PMID: 19954915.

5: Shakya AK, Arafat TA, Abuawwad AN, Melhim M, Al-Ghani J, Yacoub MJ. Simultaneous determination of triprolidine and pseudoephedrine in human plasma by liquid chromatography-ion trap mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Dec 15;877(32):4071-8. doi: 10.1016/j.jchromb.2009.10.021. Epub 2009 Oct 31. PubMed PMID: 19926351.

6: Kandimalla KK, Donovan MD. Transport of hydroxyzine and triprolidine across bovine olfactory mucosa: role of passive diffusion in the direct nose-to-brain uptake of small molecules. Int J Pharm. 2005 Sep 30;302(1-2):133-44. PubMed PMID: 16105724.

7: Shin SC, Choi JS. Enhanced efficacy of triprolidine by transdermal application of the EVA matrix system in rabbits and rats. Eur J Pharm Biopharm. 2005 Sep;61(1-2):14-9. PubMed PMID: 16005195.

8: Zayed SI, Habib IH. Adsorptive stripping voltammetric determination of triprolidine hydrochloride in pharmaceutical tablets. Farmaco. 2005 Jun-Jul;60(6-7):621-5. PubMed PMID: 15950226.

9: Shin SC, Choi JS. Antihistamine effects of triprolidine from the transdermal administration of the TPX matrix in rats. Arch Pharm Res. 2005 Jan;28(1):111-4. PubMed PMID: 15742818.

10: Zayed SI. New plastic membrane and carbon paste ion selective electrodes for the determination of triprolidine. Anal Sci. 2004 Jul;20(7):1043-8. PubMed PMID: 15293399.

11: Shin SC, Lee HJ. Enhanced transdermal delivery of triprolidine from the ethylene-vinyl acetate matrix. Eur J Pharm Biopharm. 2002 Nov;54(3):325-8. PubMed PMID: 12445563.

12: Shin SC, Lee HJ. Controlled release of triprolidine using ethylene-vinyl acetate membrane and matrix systems. Eur J Pharm Biopharm. 2002 Sep;54(2):201-6. PubMed PMID: 12191692.

13: Hindmarch, Shamsi Z. The effects of single and repeated administration of ebastine on cognition and psychomotor performance in comparison to triprolidine and placebo in healthy volunteers. Curr Med Res Opin. 2001;17(4):273-81. PubMed PMID: 11922401.

14: Shin SC, Kim J, Yoon MK, Oh IJ, Choi JS. Transdermal delivery of triprolidine using TPX polymer membrane. Int J Pharm. 2002 Mar 20;235(1-2):141-7. PubMed PMID: 11879749.

15: Shin SC, Choi JS. Enhanced bioavailability of triprolidine from the transdermal TPX matrix system in rabbits. Int J Pharm. 2002 Mar 2;234(1-2):67-73. PubMed PMID: 11839438.

16: Shin SC, Yoon MK. Application of TPX polymer membranes for the controlled release of triprolidine. Int J Pharm. 2002 Jan 31;232(1-2):131-7. PubMed PMID: 11790496.

17: Metwally FH. Kinetic spectrophotometric methods for the quantitation of triprolidine in bulk and in drug formulations. J Pharm Biomed Anal. 2001 Sep;26(2):265-72. PubMed PMID: 11470203.

18: Salunga TL, Han XY, Wong SM, Takeuchi H, Matsunami K, Upton C, Mercer AD. Blocking effects of promethazine, triprolidine and their analogues on the excitation caused by the peptide, achatin-I. Eur J Pharmacol. 1996 May 23;304(1-3):163-71. PubMed PMID: 8813599.

19: Stanley N, Alford CA, Rombaut NE, Hindmarch I. Comparison of the effects of astemizole/pseudoephedrine and triprolidine/pseudoephedrine on CNS activity and psychomotor function. Int Clin Psychopharmacol. 1996 Mar;11(1):31-6. PubMed PMID: 8732311.

20: Greenman DL, Sheldon W, Schieferstein G, Allen R, Allaben WT. Triprolidine: 104-week feeding study in rats. Fundam Appl Toxicol. 1995 Sep;27(2):223-31. PubMed PMID: 8529817.

Additional Information

Related CAS#
CAS# 6138-79-0 ( TriprolidineHCl salt);
CAS#486-12-4 ( Triprolidine free base)