Trimipramine

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 318955

CAS#: 739-71-9

Description: Trimipramine is an antidepressant with an anxiety-reducing sedative component to its action. The mode of action of Trimipramine on the central nervous system is not known. However, unlike amphetamine-type compounds it does not act primarily by stimulation of the central nervous system. It does not act by inhibition of the monoamine oxidase system.


Chemical Structure

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Trimipramine
CAS# 739-71-9

Theoretical Analysis

MedKoo Cat#: 318955
Name: Trimipramine
CAS#: 739-71-9
Chemical Formula: C20H26N2
Exact Mass: 294.2096
Molecular Weight: 294.442
Elemental Analysis: C, 81.58; H, 8.90; N, 9.51

Price and Availability

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Synonym: Trimipramine; Brand name: Surmontil, Rhotrimine, Stangyl.

IUPAC/Chemical Name: 3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,N,2-trimethylpropan-1-amine

SMILES Code: CC(CC1=CC2=CC=CCC2NC3=CC=CC=C13)CN(C)C

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 294.442 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Berger M, Gastpar M. Trimipramine: a challenge to current concepts on antidepressives. Eur Arch Psychiatry Clin Neurosci. 1996;246(5):235-9. Review. PubMed PMID: 8863001.

2: Gastpar M. Clinical originality and new biology of trimipramine. Drugs. 1989;38 Suppl 1:43-8; discussion 49-50. Review. PubMed PMID: 2693055.

3: Pecknold JC, Luthe L. Trimipramine, anxiety, depression and sleep. Drugs. 1989;38 Suppl 1:25-31; discussion 49-50. Review. PubMed PMID: 2693052.

4: Lapierre YD. A review of trimipramine. 30 years of clinical use. Drugs. 1989;38 Suppl 1:17-24; discussion 49-50. Review. PubMed PMID: 2693051.

5: Rüther E. Depression, circadian rhythms and trimipramine. Drugs. 1989;38 Suppl 1:1-3; discussion 49-50. Review. PubMed PMID: 2693050.

6: Tytgat GN, Hameeteman W, van Olffen GH. Sucralfate, bismuth compounds, substituted benzimidazoles, trimipramine and pirenzepine in the short- and long-term treatment of duodenal ulcer. Clin Gastroenterol. 1984 May;13(2):543-68. Review. PubMed PMID: 6378446.

7: Myren J. [Effect of trimipramine (Surmontil) on ventricle secretion and healing of peptic ulcer]. Tidsskr Nor Laegeforen. 1977 Feb 20;97(5):259. Review. Norwegian. PubMed PMID: 320713.