WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 317355

CAS#: 28395-03-1

Description: Bumetanide is a loop diuretic of the sulfamyl category to treat heart failure. It is often used in people in whom high doses of furosemide are ineffective. It is marketed by Hoffmann-La Roche. The main difference between the two substances is in bioavailability and pharmacodynamic potency. Furosemide is incompletely absorbed in the intestine (60%), and there are substantial inter- and intraindividual differences in bioavailability (range 10-90%). Bumetanide is almost completely absorbed (80%), and the absorption is not altered when it is taken with food. It is said to be a more predictable diuretic, meaning that the predictable absorption is reflected in a more predictable effect.

Chemical Structure

CAS# 28395-03-1

Theoretical Analysis

MedKoo Cat#: 317355
Name: Bumetanide
CAS#: 28395-03-1
Chemical Formula: C17H20N2O5S
Exact Mass: 364.10929
Molecular Weight: 364.4161
Elemental Analysis: C, 56.03; H, 5.53; N, 7.69; O, 21.95; S, 8.80

Price and Availability

Size Price Availability Quantity
10.0mg USD 60.0 2 Weeks
25.0mg USD 65.0 2 Weeks
50.0mg USD 70.0 2 Weeks
100.0mg USD 90.0 2 Weeks
200.0mg USD 120.0 2 Weeks
500.0mg USD 190.0 2 Weeks
1.0g USD 350.0 2 Weeks
2.0g USD 550.0 2 Weeks
5.0g USD 1050.0 2 Weeks
10.0g USD 1650.0 2 Weeks
20.0g USD 2650.0 2 Weeks
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Synonym: Bumetanide, Trade names: Bumex or Burinex; PF 1593, PF-1593, PF1593

IUPAC/Chemical Name: 3-(butylamino)-4-phenoxy-5-sulfamoylbenzoic acid


InChi Code: InChI=1S/C17H20N2O5S/c1-2-3-9-19-14-10-12(17(20)21)11-15(25(18,22)23)16(14)24-13-7-5-4-6-8-13/h4-8,10-11,19H,2-3,9H2,1H3,(H,20,21)(H2,18,22,23)


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 364.4161 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Mitsui R, Hashitani H. Mechanisms underlying spontaneous constrictions of
postcapillary venules in the rat stomach. Pflugers Arch. 2015 Nov 4. [Epub ahead
of print] PubMed PMID: 26530829.

2: Krueger D, Michel K, Zeller F, Demir IE, Ceyhan GO, Slotta-Huspenina J,
Schemann M. Neural influences on human intestinal epithelium in vitro. J Physiol.
2015 Nov 2. doi: 10.1113/JP271493. [Epub ahead of print] PubMed PMID: 26527433.

3: Pressler RM, Boylan GB, Marlow N, de Vries LS, Blennow M, Chiron C, Cross JH,
Hallberg B, Hellström-Westas L, Jullien V, Mangum B, Murphy B, Murray D, Pons G,
Rennie J, Toet MC, Zohar S; NEMO consortium (NEonatal seizure treatment with
Medication Off-patent). Bumetanide for neonatal seizures-back from the cotside.
Nat Rev Neurol. 2015 Nov 3. doi: 10.1038/nrneurol.2015.116. [Epub ahead of print]
PubMed PMID: 26526530.