Buclizine HCl
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MedKoo CAT#: 317354

CAS#: 129-74-8 (HCl)

Description: Buclizine is an antihistamine and anticholinergic of the piperazine derivative family. It is considered to be an antiemetic, similar to meclizine.


Chemical Structure

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Buclizine HCl
CAS# 129-74-8 (HCl)

Theoretical Analysis

MedKoo Cat#: 317354
Name: Buclizine HCl
CAS#: 129-74-8 (HCl)
Chemical Formula: C28H35Cl3N2
Exact Mass: 432.23323
Molecular Weight: 505.952
Elemental Analysis: C, 66.47; H, 6.97; Cl, 21.02; N, 5.54

Price and Availability

Size Price Availability Quantity
10.0mg USD 90.0 2 Weeks
25.0mg USD 150.0 2 Weeks
50.0mg USD 250.0 2 Weeks
100.0mg USD 450.0 2 Weeks
200.0mg USD 650.0 2 Weeks
500.0mg USD 950.0 2 Weeks
1.0g USD 1650.0 2 Weeks
2.0g USD 2450.0 2 Weeks
5.0g USD 3450.0 2 Weeks
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Related CAS #: 129-74-8 (HCl)   82-95-1 (free base).  

Synonym: AH 2526, AH-2526, AH2526; Buclizine; Buclizine dihydrochloride; UCB-4445, Buclina, Longifene, Posdel, Vibazine.

IUPAC/Chemical Name: 1-(4-(tert-butyl)benzyl)-4-((4-chlorophenyl)(phenyl)methyl)piperazine dihydrochloride

InChi Key: SDBHDSZKNVDKNU-UHFFFAOYSA-N

InChi Code: InChI=1S/C28H33ClN2.2ClH/c1-28(2,3)25-13-9-22(10-14-25)21-30-17-19-31(20-18-30)27(23-7-5-4-6-8-23)24-11-15-26(29)16-12-24;;/h4-16,27H,17-21H2,1-3H3;2*1H

SMILES Code: ClC1=CC=C(C(N2CCN(CC3=CC=C(C(C)(C)C)C=C3)CC2)C4=CC=CC=C4)C=C1.[H]Cl.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 505.952 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Kuminek G, Stulzer HK, Tagliari MP, Oliveira PR, Bernardi LS, Rauber GS,
Cardoso SG. High-performance column liquid chromatographic method for the
simultaneous determination of buclizine, tryptophan, pyridoxine, and
cyanocobalamin in tablets and oral suspension. J AOAC Int. 2011
Nov-Dec;94(6):1785-90. PubMed PMID: 22320085.

2: Babu TA. Buclizine is back again! This time as a pediatric appetite stimulant.
Indian J Pharmacol. 2011 Apr;43(2):219. doi: 10.4103/0253-7613.77383. PubMed
PMID: 21572667; PubMed Central PMCID: PMC3081471.

3: Mostafa GA, Al-Badr AA. Buclizine. Profiles Drug Subst Excip Relat Methodol.
2011;36:1-33. doi: 10.1016/B978-0-12-387667-6.00001-4. Epub 2011 Jun 23. PubMed
PMID: 22469258.