Bromazepam

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 317351

CAS#: 1812-30-2

Description: Bromazepam is a benzodiazepine derivative drug, patented by Roche in 1963 and developed clinically in the 1970s. It has mainly an anti-anxiety agent with similar side effects to diazepam (Valium). In addition to being used to treat anxiety or panic states, bromazepam may be used as a premedicant prior to minor surgery. Bromazepam is contraindicated and should be used with caution in women who are pregnant, the elderly, patients with a history of alcohol or other substance abuse disorders and children. Bromazepam is discontinued.


Chemical Structure

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Bromazepam
CAS# 1812-30-2

Theoretical Analysis

MedKoo Cat#: 317351
Name: Bromazepam
CAS#: 1812-30-2
Chemical Formula: C14H10BrN3O
Exact Mass: 315.00072
Molecular Weight: 316.15
Elemental Analysis: C, 53.19; H, 3.19; Br, 25.27; N, 13.29; O, 5.06.

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Pricing updated 2021-02-27. Prices are subject to change without notice.

Bromazepam is discontinued. (DEA controlled substance)

Synonym: Bromazepam, Ro 53350, Ro-53350, Ro53350, Lectopam, Lexotan, Lexilium, Lexaurin, Brazepam, Rekotnil, Bromaze, Somalium, Lexotanil

IUPAC/Chemical Name: 7-bromo-5-pyridin-2-yl-1,3-dihydro-1,4-benzodiazepin-2-one

InChi Key: VMIYHDSEFNYJSL-UHFFFAOYSA-N

InChi Code: InChI=1S/C14H10BrN3O/c15-9-4-5-11-10(7-9)14(17-8-13(19)18-11)12-3-1-2-6-16-12/h1-7H,8H2,(H,18,19)

SMILES Code: O=C1NC2=CC=C(Br)C=C2C(C3=NC=CC=C3)=NC1

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001

Handling Instructions:

Preparing Stock Solutions

The following data is based on the product molecular weight 316.15 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Aprigio D, Adolfo W, Bittencourt J, Gongora M, Teixeira S, Basile LF, Budde H,
Cagy M, Ribeiro P, Velasques B. Alpha power oscillation in the frontal cortex
under Bromazepam and Modafinil effects. Arq Neuropsiquiatr. 2015
Nov;73(11):918-23. doi: 10.1590/0004-282X20150140. PubMed PMID: 26517214.

2: Samanidou V, Kaltzi I, Kabir A, Furton KG. Simplifying sample preparation
using fabric phase sorptive extraction technique for the determination of
benzodiazepines in blood serum by high-performance liquid chromatography. Biomed
Chromatogr. 2015 Sep 17. doi: 10.1002/bmc.3615. [Epub ahead of print] PubMed
PMID: 26378746.