WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 317350
Description: Brinzolamide is a carbonic anhydrase inhibitor used to lower intraocular pressure in patients with open-angle glaucoma or ocular hypertension. Inhibition of carbonic anhydrase in the ciliary processes of the eye decreases aqueous humor secretion and thus lowers the intraocular pressure in the anterior chamber, presumably by reducing the rate of formation of bicarbonate ions with subsequent reduction in sodium and fluid transport; this alleviates the effects of open-angle glaucoma.
MedKoo Cat#: 317350
Chemical Formula: C12H21N3O5S3
Exact Mass: 383.06433
Molecular Weight: 383.51
Elemental Analysis: C, 37.58; H, 5.52; N, 10.96; O, 20.86; S, 25.08.
Synonym: AL-4862; AL 4862; AL4862; Brinzolamide; trade names Azopt, Alcon Laboratories, Befardin, Fardi Medicals
IUPAC/Chemical Name: (4R)-4-(ethylamino)-2-(3-methoxypropyl)-1,1-dioxo-3,4-dihydrothieno[3,2-e]thiazine-6-sulfonamide
InChi Key: HCRKCZRJWPKOAR-JTQLQIEISA-N
InChi Code: InChI=1S/C12H21N3O5S3/c1-3-14-10-8-15(5-4-6-20-2)23(18,19)12-9(10)7-11(21-12)22(13,16)17/h7,10,14H,3-6,8H2,1-2H3,(H2,13,16,17)/t10-/m0/s1
SMILES Code: O=S(C(S1)=CC2=C1S(N(CCCOC)C[C@@H]2NCC)(=O)=O)(N)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 383.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Hommer A, Hubatsch DA, Cano-Parra J. Safety and Efficacy of Adding
Fixed-Combination Brinzolamide/Timolol Maleate to Prostaglandin Therapy for
Treatment of Ocular Hypertension or Glaucoma. J Ophthalmol. 2015;2015:131970.
doi: 10.1155/2015/131970. Epub 2015 Oct 1. PubMed PMID: 26495134; PubMed Central
2: Li H, Liu Y, Zhang Y, Fang D, Xu B, Zhang L, Chen T, Ren K, Nie Y, Yao S, Song
X. Liposomes as a Novel Ocular Delivery System for Brinzolamide: In Vitro and In
Vivo Studies. AAPS PharmSciTech. 2015 Sep 3. [Epub ahead of print] PubMed PMID: