Brinzolamide
featured

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 317350

CAS#: 138890-62-7

Description: Brinzolamide is a carbonic anhydrase inhibitor used to lower intraocular pressure in patients with open-angle glaucoma or ocular hypertension. Inhibition of carbonic anhydrase in the ciliary processes of the eye decreases aqueous humor secretion and thus lowers the intraocular pressure in the anterior chamber, presumably by reducing the rate of formation of bicarbonate ions with subsequent reduction in sodium and fluid transport; this alleviates the effects of open-angle glaucoma.

Chemical Structure

img
Brinzolamide
CAS# 138890-62-7
Instruction

Theoretical Analysis

MedKoo Cat#: 317350
Name: Brinzolamide
CAS#: 138890-62-7
Chemical Formula: C12H21N3O5S3
Exact Mass: 383.06
Molecular Weight: 383.510
Elemental Analysis: C, 37.58; H, 5.52; N, 10.96; O, 20.86; S, 25.08.

Price and Availability

Size Price Availability Quantity
25mg USD 150
100mg USD 450
200mg USD 750
Bulk inquiry

Synonym: AL-4862; AL 4862; AL4862; Brinzolamide; trade names Azopt, Alcon Laboratories, Befardin, Fardi Medicals

IUPAC/Chemical Name: (4R)-4-(ethylamino)-2-(3-methoxypropyl)-1,1-dioxo-3,4-dihydrothieno[3,2-e]thiazine-6-sulfonamide

InChi Key: HCRKCZRJWPKOAR-JTQLQIEISA-N

InChi Code: InChI=1S/C12H21N3O5S3/c1-3-14-10-8-15(5-4-6-20-2)23(18,19)12-9(10)7-11(21-12)22(13,16)17/h7,10,14H,3-6,8H2,1-2H3,(H2,13,16,17)/t10-/m0/s1

SMILES Code: O=S(C(S1)=CC2=C1S(N(CCCOC)C[C@@H]2NCC)(=O)=O)(N)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 383.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Hommer A, Hubatsch DA, Cano-Parra J. Safety and Efficacy of Adding
Fixed-Combination Brinzolamide/Timolol Maleate to Prostaglandin Therapy for
Treatment of Ocular Hypertension or Glaucoma. J Ophthalmol. 2015;2015:131970.
doi: 10.1155/2015/131970. Epub 2015 Oct 1. PubMed PMID: 26495134; PubMed Central
PMCID: PMC4606181.


2: Li H, Liu Y, Zhang Y, Fang D, Xu B, Zhang L, Chen T, Ren K, Nie Y, Yao S, Song
X. Liposomes as a Novel Ocular Delivery System for Brinzolamide: In Vitro and In
Vivo Studies. AAPS PharmSciTech. 2015 Sep 3. [Epub ahead of print] PubMed PMID:
26335415.