Brinzolamide
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 317350

CAS#: 138890-62-7

Description: Brinzolamide is a carbonic anhydrase inhibitor used to lower intraocular pressure in patients with open-angle glaucoma or ocular hypertension. Inhibition of carbonic anhydrase in the ciliary processes of the eye decreases aqueous humor secretion and thus lowers the intraocular pressure in the anterior chamber, presumably by reducing the rate of formation of bicarbonate ions with subsequent reduction in sodium and fluid transport; this alleviates the effects of open-angle glaucoma.


Chemical Structure

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Brinzolamide
CAS# 138890-62-7

Theoretical Analysis

MedKoo Cat#: 317350
Name: Brinzolamide
CAS#: 138890-62-7
Chemical Formula: C12H21N3O5S3
Exact Mass: 383.06433
Molecular Weight: 383.51
Elemental Analysis: C, 37.58; H, 5.52; N, 10.96; O, 20.86; S, 25.08.

Size Price Shipping out time Quantity
25mg USD 150 2 Weeks
100mg USD 450 2 Weeks
200mg USD 750 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2021-02-26. Prices are subject to change without notice.

Brinzolamide, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.

Synonym: AL-4862; AL 4862; AL4862; Brinzolamide; trade names Azopt, Alcon Laboratories, Befardin, Fardi Medicals

IUPAC/Chemical Name: (4R)-4-(ethylamino)-2-(3-methoxypropyl)-1,1-dioxo-3,4-dihydrothieno[3,2-e]thiazine-6-sulfonamide

InChi Key: HCRKCZRJWPKOAR-JTQLQIEISA-N

InChi Code: InChI=1S/C12H21N3O5S3/c1-3-14-10-8-15(5-4-6-20-2)23(18,19)12-9(10)7-11(21-12)22(13,16)17/h7,10,14H,3-6,8H2,1-2H3,(H2,13,16,17)/t10-/m0/s1

SMILES Code: O=S(C(S1)=CC2=C1S(N(CCCOC)C[C@@H]2NCC)(=O)=O)(N)=O

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001

Handling Instructions:

Preparing Stock Solutions

The following data is based on the product molecular weight 383.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Hommer A, Hubatsch DA, Cano-Parra J. Safety and Efficacy of Adding
Fixed-Combination Brinzolamide/Timolol Maleate to Prostaglandin Therapy for
Treatment of Ocular Hypertension or Glaucoma. J Ophthalmol. 2015;2015:131970.
doi: 10.1155/2015/131970. Epub 2015 Oct 1. PubMed PMID: 26495134; PubMed Central
PMCID: PMC4606181.

2: Li H, Liu Y, Zhang Y, Fang D, Xu B, Zhang L, Chen T, Ren K, Nie Y, Yao S, Song
X. Liposomes as a Novel Ocular Delivery System for Brinzolamide: In Vitro and In
Vivo Studies. AAPS PharmSciTech. 2015 Sep 3. [Epub ahead of print] PubMed PMID:
26335415.