WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 558220
CAS#: 1513879-18-9
Description: KAI407 is a potent non-8-aminoquinoline compound that kills Plasmodium cynomolgi early dormant liver stage parasites in vitro. KAI407 showed an activity profile similar to that of primaquine (PQ), efficiently killing the earliest stages of the parasites that become either primary hepatic schizonts or hypnozoites (50% inhibitory concentration [IC50] for hypnozoites, KAI407, 0.69 μM, and PQ, 0.84 μM; for developing liver stages, KAI407, 0.64 μM, and PQ, 0.37 μM). KAI407 may represent a new compound class for P. vivax malaria prophylaxis and potentially a radical cure.
MedKoo Cat#: 558220
Name: KAI-407
CAS#: 1513879-18-9
Chemical Formula: C22H14F3N5O
Exact Mass: 421.11504
Molecular Weight: 421.38321
Elemental Analysis: C, 62.71; H, 3.35; F, 13.53; N, 16.62; O, 3.80
KAI-407 is not in stock, but may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.
Synonym: KAI-407; KAI 407; KAI407.
IUPAC/Chemical Name: N-(4-cyanophenyl)-N-methyl-3-(4-(trifluoromethyl)phenyl)imidazo[1,2-a]pyrazine-6-carboxamide
InChi Key: XAZOWMVYGFASLH-UHFFFAOYSA-N
InChi Code: InChI=1S/C22H14F3N5O/c1-29(17-8-2-14(10-26)3-9-17)21(31)18-13-30-19(11-28-20(30)12-27-18)15-4-6-16(7-5-15)22(23,24)25/h2-9,11-13H,1H3
SMILES Code: O=C(C1=CN2C(C=N1)=NC=C2C3=CC=C(C(F)(F)F)C=C3)N(C4=CC=C(C#N)C=C4)C
The following data is based on the product molecular weight 421.38321 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Zou B, Nagle A, Chatterjee AK, Leong SY, Tan LJ, Sim WL, Mishra P, Guntapalli
P, Tully DC, Lakshminarayana SB, Lim CS, Tan YC, Abas SN, Bodenreider C, Kuhen
KL, Gagaring K, Borboa R, Chang J, Li C, Hollenbeck T, Tuntland T, Zeeman AM,
Kocken CH, McNamara C, Kato N, Winzeler EA, Yeung BK, Diagana TT, Smith PW,
Roland J. Lead optimization of imidazopyrazines: a new class of antimalarial with
activity on Plasmodium liver stages. ACS Med Chem Lett. 2014 Jul 6;5(8):947-50.
doi: 10.1021/ml500244m. eCollection 2014 Aug 14. PubMed PMID: 25147620; PubMed
Central PMCID: PMC4137381.
2: Zeeman AM, van Amsterdam SM, McNamara CW, Voorberg-van der Wel A, Klooster EJ,
van den Berg A, Remarque EJ, Plouffe DM, van Gemert GJ, Luty A, Sauerwein R,
Gagaring K, Borboa R, Chen Z, Kuhen K, Glynne RJ, Chatterjee AK, Nagle A, Roland
J, Winzeler EA, Leroy D, Campo B, Diagana TT, Yeung BK, Thomas AW, Kocken CH.
KAI407, a potent non-8-aminoquinoline compound that kills Plasmodium cynomolgi
early dormant liver stage parasites in vitro. Antimicrob Agents Chemother.
2014;58(3):1586-95. doi: 10.1128/AAC.01927-13. Epub 2013 Dec 23. PubMed PMID:
24366744; PubMed Central PMCID: PMC3957848.
