WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 407216

CAS#: 403646-00-4

Description: MC-205 is a new transcriptional up-regulator and a natural fungal metabolite with antiproliferative activity against cancer cell lines. Expression of the luciferase activity was activated ca. 2-, 4-, and 6-fold by 1, 10, and 100 microM TMC-205, respectively. TMC-205 activated the transcriptional activity in a manner dependent on the presence of the enhancer element of SV40 in its promoter region.

Chemical Structure

CAS# 403646-00-4

Theoretical Analysis

MedKoo Cat#: 407216
Name: TMC-205
CAS#: 403646-00-4
Chemical Formula: C14H13NO2
Exact Mass: 227.09463
Molecular Weight: 227.263
Elemental Analysis: C, 73.99; H, 5.77; N, 6.16; O, 14.08

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Synonym: TMC-205; TMC 205; TMC205.

IUPAC/Chemical Name: (E)-6-(3-methylbuta-1,3-dien-1-yl)-1H-indole-3-carboxylic acid


InChi Code: InChI=1S/C14H13NO2/c1-9(2)3-4-10-5-6-11-12(14(16)17)8-15-13(11)7-10/h3-8,15H,1H2,2H3,(H,16,17)/b4-3+

SMILES Code: O=C(C1=CNC2=C1C=CC(/C=C/C(C)=C)=C2)O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 227.263 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Gao Y, Osman S, Koide K. Total Synthesis and Biological Studies of TMC-205 and
Analogues as Anticancer Agents and Activators of SV40 Promoter. ACS Med Chem
Lett. 2014 Jun 23;5(8):863-7. doi: 10.1021/ml500025p. eCollection 2014 Aug 14.
PubMed PMID: 25147604; PubMed Central PMCID: PMC4137371.

2: Sakurai M, Kohno J, Nishio M, Yamamoto K, Okuda T, Kawano K, Nakanishi N.
TMC-205 a new transcriptional up-regulator of SV40 promoter produced by an
unidentified fungus. Fermentation, isolation, physico-chemical properties,
structural determination and biological activities. J Antibiot (Tokyo). 2001
Aug;54(8):628-34. PubMed PMID: 11592499.