WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 522496
Description: ML398 is potent D4 receptor Antagonist with IC50 = 130 nM and K i = 36 nM and shows no activity against the other dopamine receptors tested (>20 μM against D1, D2S, D2L, D3, and D5). Further in vivo studies showed that ML398 reversed cocaine-induced hyperlocomotion at 10 mg/kg. ML398 shows >100-fold selectivity for the other dopamine receptors.
MedKoo Cat#: 522496
Name: ML398 HCl salt
Chemical Formula: C20H24ClN3O
Molecular Weight: 357.882
Elemental Analysis: C, 67.12; H, 6.76; Cl, 9.91; N, 11.74; O, 4.47
ML398 HCl is not in stock, but may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to firstname.lastname@example.org to inquire quote.
Synonym: ML398; ML-398; ML 398. ML398 HCl salt.
IUPAC/Chemical Name: (R)-4-((1H-benzo[d]imidazol-2-yl)methyl)-2-phenethylmorpholine hydrochloride
InChi Key: UVMILKJETIKUBK-UNTBIKODSA-N
InChi Code: InChI=1S/C20H23N3O.ClH/c1-2-6-16(7-3-1)10-11-17-14-23(12-13-24-17)15-20-21-18-8-4-5-9-19(18)22-20;/h1-9,17H,10-15H2,(H,21,22);1H/t17-;/m1./s1
SMILES Code: [H]Cl.C1(CN2C[C@@H](CCC3=CC=CC=C3)OCC2)=NC4=CC=CC=C4N1
The following data is based on the product molecular weight 357.882 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Berry CB, Locuson CW, Daniels JS, Lindsley CW, Hopkins CR. Discovery and
characterization of ML398, a potent and selective chiral morpholine based
antagonist of the dopamine 4 (D(4)) receptor. 2014 Apr 15 [updated 2015 Jan 16].
Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD):
National Center for Biotechnology Information (US); 2010-. Available from
PubMed PMID: 25834901.
2: Berry CB, Bubser M, Jones CK, Hayes JP, Wepy JA, Locuson CW, Daniels JS,
Lindsley CW, Hopkins CR. Discovery and Characterization of ML398, a Potent and
Selective Antagonist of the D4 Receptor with in Vivo Activity. ACS Med Chem Lett.
2014 Jul 9;5(9):1060-4. doi: 10.1021/ml500267c. eCollection 2014 Sep 11. PubMed
PMID: 25221667; PubMed Central PMCID: PMC4160761.
3: Luschini MA, Fletcher DJ, Schoeffler GL. Incidence of ionized hypocalcemia in
septic dogs and its association with morbidity and mortality: 58 cases
(2006-2007). J Vet Emerg Crit Care (San Antonio). 2010 Aug;20(4):406-12. doi:
10.1111/j.1476-4431.2010.00553.x. PubMed PMID: 20731806.