ONO-2050297

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 522491

CAS#: 1637756-67-2

Description: ONO-2050297 is the first potent dual CysLT1 and CysLT2 antagonist with IC50 values of 0.017 μM (CysLT1) and 0.00087 μM (CysLT2), respectively.


Chemical Structure

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ONO-2050297
CAS# 1637756-67-2

Theoretical Analysis

MedKoo Cat#: 522491
Name: ONO-2050297
CAS#: 1637756-67-2
Chemical Formula: C30H32N2O7
Exact Mass: 532.22095
Molecular Weight: 532.593
Elemental Analysis: C, 67.66; H, 6.06; N, 5.26; O, 21.03

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Synonym: ONO-2050297; ONO 2050297; ONO2050297.

IUPAC/Chemical Name: (S)-4-(3-carboxypropyl)-8-(4-(4-phenylbutoxy)benzamido)-3,4-dihydro-2H-benzo[b][1,4]oxazine-2-carboxylic acid

InChi Key: CCNFJZLJCWVIGY-SANMLTNESA-N

InChi Code: InChI=1S/C30H32N2O7/c33-27(34)13-7-18-32-20-26(30(36)37)39-28-24(11-6-12-25(28)32)31-29(35)22-14-16-23(17-15-22)38-19-5-4-10-21-8-2-1-3-9-21/h1-3,6,8-9,11-12,14-17,26H,4-5,7,10,13,18-20H2,(H,31,35)(H,33,34)(H,36,37)/t26-/m0/s1

SMILES Code: O=C([C@H]1OC2=C(NC(C3=CC=C(OCCCCC4=CC=CC=C4)C=C3)=O)C=CC=C2N(CCCC(O)=O)C1)O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 532.593 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Itadani S, Takahashi S, Ima M, Sekiguchi T, Fujita M, Nakayama Y, Takeuchi J.
Discovery of Highly Potent Dual CysLT1 and CysLT2 Antagonist. ACS Med Chem Lett.
2014 Oct 6;5(11):1230-4. doi: 10.1021/ml500298y. eCollection 2014 Nov 13. PubMed
PMID: 25408836; PubMed Central PMCID: PMC4233365.