WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 522491
Description: ONO-2050297 is the first potent dual CysLT1 and CysLT2 antagonist with IC50 values of 0.017 μM (CysLT1) and 0.00087 μM (CysLT2), respectively.
MedKoo Cat#: 522491
Chemical Formula: C30H32N2O7
Exact Mass: 532.22095
Molecular Weight: 532.593
Elemental Analysis: C, 67.66; H, 6.06; N, 5.26; O, 21.03
Synonym: ONO-2050297; ONO 2050297; ONO2050297.
IUPAC/Chemical Name: (S)-4-(3-carboxypropyl)-8-(4-(4-phenylbutoxy)benzamido)-3,4-dihydro-2H-benzo[b][1,4]oxazine-2-carboxylic acid
InChi Key: CCNFJZLJCWVIGY-SANMLTNESA-N
InChi Code: InChI=1S/C30H32N2O7/c33-27(34)13-7-18-32-20-26(30(36)37)39-28-24(11-6-12-25(28)32)31-29(35)22-14-16-23(17-15-22)38-19-5-4-10-21-8-2-1-3-9-21/h1-3,6,8-9,11-12,14-17,26H,4-5,7,10,13,18-20H2,(H,31,35)(H,33,34)(H,36,37)/t26-/m0/s1
SMILES Code: O=C([C@H]1OC2=C(NC(C3=CC=C(OCCCCC4=CC=CC=C4)C=C3)=O)C=CC=C2N(CCCC(O)=O)C1)O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 532.593 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Itadani S, Takahashi S, Ima M, Sekiguchi T, Fujita M, Nakayama Y, Takeuchi J.
Discovery of Highly Potent Dual CysLT1 and CysLT2 Antagonist. ACS Med Chem Lett.
2014 Oct 6;5(11):1230-4. doi: 10.1021/ml500298y. eCollection 2014 Nov 13. PubMed
PMID: 25408836; PubMed Central PMCID: PMC4233365.