AM-9514

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 522490

CAS#: 1442677-18-0

Description: AM-9514 is a novel, potent Glucokinase (GK) activator. AM-9514 showed a favorable combination of in vitro potency, enzyme kinetic properties, acceptable pharmacokinetic profiles in preclinical species, and robust efficacy in a rodent PD model. Glucokinase (GK) activators represent a class of type 2 diabetes therapeutics actively pursued due to the central role that GK plays in regulating glucose homeostasis.


Chemical Structure

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AM-9514
CAS# 1442677-18-0

Theoretical Analysis

MedKoo Cat#: 522490
Name: AM-9514
CAS#: 1442677-18-0
Chemical Formula: C18H25N5O3
Exact Mass: 359.19574
Molecular Weight: 359.43
Elemental Analysis: C, 60.15; H, 7.01; N, 19.49; O, 13.35

Size Price Shipping out time Quantity
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Pricing updated 2021-03-08. Prices are subject to change without notice.

AM-9514, is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.

Synonym: AM-9514; AM9514; AM 9514.

IUPAC/Chemical Name: 1-(3-((1-ethyl-1H-pyrazol-5-yl)oxy)-5-(((1r,3s)-3-hydroxy-3-methylcyclobutyl)methyl)pyridin-2-yl)-3-methylurea

InChi Key: AZHFAXGDRCIDKF-KTXOBNNYSA-N

InChi Code: InChI=1S/C18H25N5O3/c1-4-23-15(5-6-21-23)26-14-8-12(7-13-9-18(2,25)10-13)11-20-16(14)22-17(24)19-3/h5-6,8,11,13,25H,4,7,9-10H2,1-3H3,(H2,19,20,22,24)/t13-,18-

SMILES Code: O=C(NC)NC1=NC=C(C[C@H]2C[C@](C)(O)C2)C=C1OC3=CC=NN3CC

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001

Handling Instructions:

Preparing Stock Solutions

The following data is based on the product molecular weight 359.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Du X, Hinklin RJ, Xiong Y, Dransfield P, Park J, Kohn TJ, Pattaropong V, Lai
S, Fu Z, Jiao X, Chow D, Jin L, Davda J, Veniant MM, Anderson DA, Baer BR,
Bencsik JR, Boyd SA, Chicarelli MJ, Mohr PJ, Wang B, Condroski KR, DeWolf WE,
Conn M, Tran T, Yang J, Aicher TD, Medina JC, Coward P, Houze JB.
C5-Alkyl-2-methylurea-Substituted Pyridines as a New Class of Glucokinase
Activators. ACS Med Chem Lett. 2014 Nov 22;5(12):1284-9. doi: 10.1021/ml500341w.
eCollection 2014 Dec 11. PubMed PMID: 25516785; PubMed Central PMCID: PMC4265826.