WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 522490
CAS#: 1442677-18-0
Description: AM-9514 is a novel, potent Glucokinase (GK) activator. AM-9514 showed a favorable combination of in vitro potency, enzyme kinetic properties, acceptable pharmacokinetic profiles in preclinical species, and robust efficacy in a rodent PD model. Glucokinase (GK) activators represent a class of type 2 diabetes therapeutics actively pursued due to the central role that GK plays in regulating glucose homeostasis.
MedKoo Cat#: 522490
Name: AM-9514
CAS#: 1442677-18-0
Chemical Formula: C18H25N5O3
Exact Mass: 359.19574
Molecular Weight: 359.43
Elemental Analysis: C, 60.15; H, 7.01; N, 19.49; O, 13.35
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Synonym: AM-9514; AM9514; AM 9514.
IUPAC/Chemical Name: 1-(3-((1-ethyl-1H-pyrazol-5-yl)oxy)-5-(((1r,3s)-3-hydroxy-3-methylcyclobutyl)methyl)pyridin-2-yl)-3-methylurea
InChi Key: AZHFAXGDRCIDKF-KTXOBNNYSA-N
InChi Code: InChI=1S/C18H25N5O3/c1-4-23-15(5-6-21-23)26-14-8-12(7-13-9-18(2,25)10-13)11-20-16(14)22-17(24)19-3/h5-6,8,11,13,25H,4,7,9-10H2,1-3H3,(H2,19,20,22,24)/t13-,18-
SMILES Code: O=C(NC)NC1=NC=C(C[C@H]2C[C@](C)(O)C2)C=C1OC3=CC=NN3CC
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 359.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Du X, Hinklin RJ, Xiong Y, Dransfield P, Park J, Kohn TJ, Pattaropong V, Lai
S, Fu Z, Jiao X, Chow D, Jin L, Davda J, Veniant MM, Anderson DA, Baer BR,
Bencsik JR, Boyd SA, Chicarelli MJ, Mohr PJ, Wang B, Condroski KR, DeWolf WE,
Conn M, Tran T, Yang J, Aicher TD, Medina JC, Coward P, Houze JB.
C5-Alkyl-2-methylurea-Substituted Pyridines as a New Class of Glucokinase
Activators. ACS Med Chem Lett. 2014 Nov 22;5(12):1284-9. doi: 10.1021/ml500341w.
eCollection 2014 Dec 11. PubMed PMID: 25516785; PubMed Central PMCID: PMC4265826.
