WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 317313
CAS#: 132-17-2
Description: Benztropine is a synthetic compound derived from the combination of atropine and diphenhydramine that acts centrally to antagonize M1 muscarinic acetylcholine receptors. Benztropine has been used in the management of Parkinson’s disease symptoms to address involuntary tremor and dystonia. It can also increase the availability of dopamine by inhibiting uptake through the dopamine transporter.
MedKoo Cat#: 317313
Name: Benztropine Mesylate
CAS#: 132-17-2
Chemical Formula: C22H27NO4S
Exact Mass:
Molecular Weight: 401.52
Elemental Analysis: C, 65.81; H, 6.78; N, 3.49; O, 15.94; S, 7.99
Benztropine Mesylate, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.
Synonym: Benztropine Mesylate; Cogentin; Cogentin mesylate; MLS000737056; Benztropine methanesulfonate; NSC42199; ST50997629; Benzotropine mesylate
IUPAC/Chemical Name: (1R,3r,5S)-3-(benzhydryloxy)-8-methyl-8-azabicyclo[3.2.1]octane methanesulfonate
InChi Key: CPFJLLXFNPCTDW-BWSPSPBFSA-N
InChi Code: InChI=1S/C21H25NO.CH4O3S/c1-22-18-12-13-19(22)15-20(14-18)23-21(16-8-4-2-5-9-16)17-10-6-3-7-11-17;1-5(2,3)4/h2-11,18-21H,12-15H2,1H3;1H3,(H,2,3,4)/t18-,19+,20+;
SMILES Code: CN1[C@@H]2C[C@@H](OC(C3=CC=CC=C3)C4=CC=CC=C4)C[C@H]1CC2.OS(C)(=O)=O
The following data is based on the product molecular weight 401.52 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
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olanzapine and subsequently with benztropine mesylate. Psychosomatics. 2000
May-Jun;41(3):277-8. PubMed PMID: 10849461.
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7879808.
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benztropine mesylate. Am J Psychiatry. 1992 May;149(5):711. PubMed PMID: 1575268.
4: Rosenberg JM, Sideman M, Kampa IS, McGuire H, Kampa L. Effects of benztropine
mesylate on haloperidol-induced prolactin secretion and serum haloperidol levels
in rats. J Pharm Sci. 1984 Dec;73(12):1833-5. PubMed PMID: 6527272.
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PMID: 6362765.
6: Thaler JS. Effects of benztropine mesylate (Cogentin) on accommodation in
normal volunteers. Am J Optom Physiol Opt. 1982 Nov;59(11):918-9. PubMed PMID:
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8: Rapp MS. Benztropine mesylate and social anxiety. Am J Psychiatry. 1979
Dec;136(12):1611. PubMed PMID: 507226.
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syndrome and tardive dyskinesia. Am J Psychiatry. 1977 Nov;134(11):1301-2. PubMed
PMID: 910992.
10: Stenson RL, Donion PT, Meyer JE. Comparison of benztropine mesylate and
amantadine HCl in neuroleptic-induced extrapyramidal symptoms. Compr Psychiatry.
1976 Nov-Dec;17(6):763-8. PubMed PMID: 791573.
11: el-Yousef MK, Manier DH. Letter: The effect of benztropine mesylate on plasma
levels of butaperazine maleate. Am J Psychiatry. 1974 Apr;131(4):471-2. PubMed
PMID: 4149998.
12: Kelly JT, Zimmermann RL, Abuzzahab FS, Schiele BC. A double-blind study of
amantadine hydrochloride versus benztropine mesylate in drug-induced
parkinsonism. Pharmacology. 1974;12(2):65-73. PubMed PMID: 4610599.
13: Stricklin MC. Collaborative study of a colorimetric determination of
benztropine mesylate in tablets and injections. J Assoc Off Anal Chem. 1973
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14: Mushet GR, Dreifuss FE. Paroxysmal dyskinesia. A case responsive to
benztropine mesylate. Arch Dis Child. 1967 Dec;42(226):654-6. PubMed PMID:
4965319; PubMed Central PMCID: PMC2019877.
15: Hanlon TE, Schoenrich C, Freinek W, Turek I, Kurland AA.
Perphenazine-benztropine mesylate treatment of newly admitted psychiatric
patients. Psychopharmacologia. 1966;9(4):328-39. PubMed PMID: 4874349.
