WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 522488
Description: PF-04937319 is a glucokinase activator which is under development for the treatment of type 2 diametes mellitus. Glucose-phosphorylating enzyme, glucokinase (GK) plays a major role in glucose homeostasis primarily through its regulatory actions in pancreatic β-cells and liver hepatocytes. Conversion of glucose to glucose-6-phosphate by GK promotes glycogen synthesis in liver hepatocytes, and insulin release in the pancreatic β-cells.
MedKoo Cat#: 522488
Chemical Formula: C22H20N6O4
Exact Mass: 432.1546
Molecular Weight: 432.44
Elemental Analysis: C, 61.10; H, 4.66; N, 19.43; O, 14.80
PF-04937319, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.
Synonym: PF-04937319; PF04937319; PF 04937319; PF-4937319; PF 4937319; PF4937319.
IUPAC/Chemical Name: N,N-dimethyl-5-((2-methyl-6-((5-methylpyrazin-2-yl)carbamoyl)benzofuran-4-yl)oxy)pyrimidine-2-carboxamide
InChi Key: MASKQITXHVYVFL-UHFFFAOYSA-N
InChi Code: InChI=1S/C22H20N6O4/c1-12-8-24-19(11-23-12)27-21(29)14-6-17-16(5-13(2)31-17)18(7-14)32-15-9-25-20(26-10-15)22(30)28(3)4/h5-11H,1-4H3,(H,24,27,29)
SMILES Code: O=C(C1=NC=C(OC2=C3C=C(C)OC3=CC(C(NC4=NC=C(C)N=C4)=O)=C2)C=N1)N(C)C
The following data is based on the product molecular weight 432.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Amin NB, Aggarwal N, Pall D, Paragh G, Denney WS, Le V, Riggs M, Calle RA. Two
dose-ranging studies with PF-04937319, a systemic partial activator of
glucokinase, as add-on therapy to metformin in adults with type 2 diabetes.
Diabetes Obes Metab. 2015 Aug;17(8):751-9. doi: 10.1111/dom.12474. Epub 2015 May
11. PubMed PMID: 25885172.
2: Sharma R, Litchfield J, Atkinson K, Eng H, Amin NB, Denney WS, Pettersen JC,
Goosen TC, Di L, Lee E, Pfefferkorn JA, Dalvie DK, Kalgutkar AS. Metabolites in
safety testing assessment in early clinical development: a case study with a
glucokinase activator. Drug Metab Dispos. 2014 Nov;42(11):1926-39. doi:
10.1124/dmd.114.060087. Epub 2014 Aug 20. PubMed PMID: 25142735.
3: Pettersen JC, Litchfield J, Neef N, Schmidt SP, Shirai N, Walters KM, Enerson
BE, Chatman LA, Pfefferkorn JA. The relationship of glucokinase activator-induced
hypoglycemia with arteriopathy, neuronal necrosis, and peripheral neuropathy in
nonclinical studies. Toxicol Pathol. 2014 Jun;42(4):696-708. doi:
10.1177/0192623314526006. Epub 2014 Apr 24. PubMed PMID: 24771080.