WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 407207
Description: AZ9482 is a potent and selective PARP inhibitor featuring an amide linkage to a 2-piperazinyl-3-cyano-pyridine. AZ9482 exhibits very potent centrosome declustering activity in HeLa cells (EC50 < 18 nM). Encouragingly, AZ9482 also showed a 3 nM GI50 in the DLBCL cell line OCI-LY-19 in a 3-day AlamarBlue assay. Consistent with published siRNA knockdown experiments, AZ9482 was a 9 nM enzyme inhibitor of tankyrase 1 (TNKS1).
MedKoo Cat#: 407207
Chemical Formula: C26H22N6O2
Exact Mass: 450.18042
Molecular Weight: 450.502
Elemental Analysis: C, 69.32; H, 4.92; N, 18.66; O, 7.10
AZ9482, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.
Synonym: AZ9482; AZ-9482; AZ 9482.
IUPAC/Chemical Name: 2-(4-(3-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoyl)piperazin-1-yl)nicotinonitrile
InChi Key: ZDDPBFWHZOJFHF-UHFFFAOYSA-N
InChi Code: InChI=1S/C26H22N6O2/c27-17-20-7-4-10-28-24(20)31-11-13-32(14-12-31)26(34)19-6-3-5-18(15-19)16-23-21-8-1-2-9-22(21)25(33)30-29-23/h1-10,15H,11-14,16H2,(H,30,33)
SMILES Code: O=C1NN=C(CC2=CC=CC(C(N3CCN(C4=NC=CC=C4C#N)CC3)=O)=C2)C5=CC=CC=C51
The following data is based on the product molecular weight 450.502 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
Jeffrey W. Johannes, Lynsie Almeida, Kevin Daly, Andrew D. Ferguson, Shaun E. Grosskurth, Huiping Guan, Tina Howard, Stephanos Ioannidis, Steven Kazmirski, Michelle L. Lamb, Nicholas A. Larsen, Paul D. Lyne, Keith Mikule, Claude Ogoe, Bo Peng, Philip Petteruti, Jon A. Read, Nancy Su, Mark Sylvester, Scott Throner, Wenxian Wang, et al. Discovery of AZ0108, an orally bioavailable phthalazinone PARP inhibitor that blocks centrosome clustering
In Press, Corrected Proof, Available online 27 October 2015. Bioorg. Med. Chem . Lett. 2015.