WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 522482
CAS#: 733750-99-7
Description: AR231453 is a potent and selective GPR119 agonist, AR231453 can stimulate β-cell replication and improve islet graft function.
MedKoo Cat#: 522482
Name: AR231453
CAS#: 733750-99-7
Chemical Formula: C21H24FN7O5S
Exact Mass: 505.15437
Molecular Weight: 505.5254
Elemental Analysis: C, 49.89; H, 4.79; F, 3.76; N, 19.40; O, 15.82; S, 6.34
AR231453, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.
Synonym: AR231453; AR-231453; AR 231453; AR-231,453; AR231,453; AR231,453.
IUPAC/Chemical Name: N-(2-fluoro-4-methanesulfonylphenyl)-(6-[4-(3-isopropyl-[1,2,4]oxadiazol-5-yl)-piperidin-1-yl]-5-nitropyrimidin-4-yl)amine
InChi Key: DGBKNTVAKIFYNU-UHFFFAOYSA-N
InChi Code: InChI=1S/C21H24FN7O5S/c1-12(2)18-26-21(34-27-18)13-6-8-28(9-7-13)20-17(29(30)31)19(23-11-24-20)25-16-5-4-14(10-15(16)22)35(3,32)33/h4-5,10-13H,6-9H2,1-3H3,(H,23,24,25)
SMILES Code: O=[N+](C1=C(N2CCC(C3=NC(C(C)C)=NO3)CC2)N=CN=C1NC4=CC=C(S(=O)(C)=O)C=C4F)[O-]
The following data is based on the product molecular weight 505.5254 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
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2: Engelstoft MS, Norn C, Hauge M, Holliday ND, Elster L, Lehmann J, Jones RM, Frimurer TM, Schwartz TW. Structural basis for constitutive activity and agonist-induced activation of the enteroendocrine fat sensor GPR119. Br J Pharmacol. 2014 Dec;171(24):5774-89. doi: 10.1111/bph.12877. PubMed PMID: 25117266; PubMed Central PMCID: PMC4290716.
3: Zhang M, Feng Y, Wang J, Zhao J, Li T, He M, Yang D, Nosjean O, Boutin J, Renard P, Wang MW. High-throughput screening for GPR119 modulators identifies a novel compound with anti-diabetic efficacy in db/db mice. PLoS One. 2013 May 21;8(5):e63861. doi: 10.1371/journal.pone.0063861. Print 2013. PubMed PMID: 23704946; PubMed Central PMCID: PMC3660563.
4: Gao J, Tian L, Weng G, O'Brien TD, Luo J, Guo Z. Stimulating β-cell replication and improving islet graft function by AR231453, A GPR119 agonist. Transplant Proc. 2011 Nov;43(9):3217-20. doi: 10.1016/j.transproceed.2011.10.021. PubMed PMID: 22099761.
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12: Chu ZL, Carroll C, Alfonso J, Gutierrez V, He H, Lucman A, Pedraza M, Mondala H, Gao H, Bagnol D, Chen R, Jones RM, Behan DP, Leonard J. A role for intestinal endocrine cell-expressed g protein-coupled receptor 119 in glycemic control by enhancing glucagon-like Peptide-1 and glucose-dependent insulinotropic Peptide release. Endocrinology. 2008 May;149(5):2038-47. doi: 10.1210/en.2007-0966. Epub 2008 Jan 17. PubMed PMID: 18202141.
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