WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 522481
CAS#: 897732-93-3
Description: APD597, also known as JNJ-38431055, is a potent and selective GPR119 agonist, which is potential useful for the treatment of type 2 diabetes. GPR119 agonists mediate a unique nutrient-dependent dual elevation of both insulin and glucagon like peptide 1/glucose-dependent insulinotropic peptide levels in vivo.
MedKoo Cat#: 522481
Name: APD597 (JNJ-38431055)
CAS#: 897732-93-3
Chemical Formula: C21H29N5O6S
Exact Mass: 479.18385
Molecular Weight: 479.552
Elemental Analysis: C, 52.60; H, 6.10; N, 14.60; O, 20.02; S, 6.69
APD597, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.
Synonym: APD597; APD-597; APD 597; JNJ-38431055; JNJ 38431055; JNJ38431055.
IUPAC/Chemical Name: isopropyl 4-((5-methoxy-6-((2-methyl-6-(methylsulfonyl)pyridin-3-yl)amino)pyrimidin-4-yl)oxy)piperidine-1-carboxylate
InChi Key: WPDCHTSXOPUOII-UHFFFAOYSA-N
InChi Code: InChI=1S/C21H29N5O6S/c1-13(2)31-21(27)26-10-8-15(9-11-26)32-20-18(30-4)19(22-12-23-20)25-16-6-7-17(24-14(16)3)33(5,28)29/h6-7,12-13,15H,8-11H2,1-5H3,(H,22,23,25)
SMILES Code: CC1=NC(S(C)(=O)=O)=CC=C1NC2=NC=NC(OC3CCN(C(OC(C)C)=O)CC3)=C2OC
The following data is based on the product molecular weight 479.552 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Buzard DJ, Kim SH, Lehmann J, Han S, Calderon I, Wong A, Kawasaki A, Narayanan
S, Bhat R, Gharbaoui T, Lopez L, Yue D, Whelan K, Al-Shamma H, Unett DJ, Shu HH,
Tung SF, Chang S, Chuang CF, Morgan M, Sadeque A, Chu ZL, Leonard JN, Jones RM.
Discovery and optimization of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists.
Bioorg Med Chem Lett. 2014 Sep 1;24(17):4332-5. doi: 10.1016/j.bmcl.2014.06.071.
Epub 2014 Jul 3. PubMed PMID: 25088191.
2: Semple G, Lehmann J, Wong A, Ren A, Bruce M, Shin YJ, Sage CR, Morgan M, Chen
WC, Sebring K, Chu ZL, Leonard JN, Al-Shamma H, Grottick AJ, Du F, Liang Y,
Demarest K, Jones RM. Discovery of a second generation agonist of the orphan
G-protein coupled receptor GPR119 with an improved profile. Bioorg Med Chem Lett.
2012 Feb 15;22(4):1750-5. doi: 10.1016/j.bmcl.2011.12.092. Epub 2011 Dec 30.
PubMed PMID: 22264481.
3: Jones RM, Leonard JN, Buzard DJ, Lehmann J. GPR119 agonists for the treatment
of type 2 diabetes. Expert Opin Ther Pat. 2009 Oct;19(10):1339-59. doi:
10.1517/13543770903153878. Review. PubMed PMID: 19780700.
