APD597 (JNJ-38431055)
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MedKoo CAT#: 522481

CAS#: 897732-93-3

Description: APD597, also known as JNJ-38431055, is a potent and selective GPR119 agonist, which is potential useful for the treatment of type 2 diabetes. GPR119 agonists mediate a unique nutrient-dependent dual elevation of both insulin and glucagon like peptide 1/glucose-dependent insulinotropic peptide levels in vivo.


Price and Availability

Size Price Shipping out time Quantity
50mg USD 250 2 Weeks
100mg USD 450 2 Weeks
200mg USD 850 2 Weeks
500mg USD 1650 2 Weeks
1g USD 2650 2 Weeks
2g USD 3650 2 Weeks
5g USD 4850 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-10-28. Prices are subject to change without notice.

APD597, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 522481
Name: APD597 (JNJ-38431055)
CAS#: 897732-93-3
Chemical Formula: C21H29N5O6S
Exact Mass: 479.18385
Molecular Weight: 479.552
Elemental Analysis: C, 52.60; H, 6.10; N, 14.60; O, 20.02; S, 6.69


Synonym: APD597; APD-597; APD 597; JNJ-38431055; JNJ 38431055; JNJ38431055.

IUPAC/Chemical Name: isopropyl 4-((5-methoxy-6-((2-methyl-6-(methylsulfonyl)pyridin-3-yl)amino)pyrimidin-4-yl)oxy)piperidine-1-carboxylate

InChi Key: WPDCHTSXOPUOII-UHFFFAOYSA-N

InChi Code: InChI=1S/C21H29N5O6S/c1-13(2)31-21(27)26-10-8-15(9-11-26)32-20-18(30-4)19(22-12-23-20)25-16-6-7-17(24-14(16)3)33(5,28)29/h6-7,12-13,15H,8-11H2,1-5H3,(H,22,23,25)

SMILES Code: CC1=NC(S(C)(=O)=O)=CC=C1NC2=NC=NC(OC3CCN(C(OC(C)C)=O)CC3)=C2OC


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Buzard DJ, Kim SH, Lehmann J, Han S, Calderon I, Wong A, Kawasaki A, Narayanan
S, Bhat R, Gharbaoui T, Lopez L, Yue D, Whelan K, Al-Shamma H, Unett DJ, Shu HH,
Tung SF, Chang S, Chuang CF, Morgan M, Sadeque A, Chu ZL, Leonard JN, Jones RM.
Discovery and optimization of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists.
Bioorg Med Chem Lett. 2014 Sep 1;24(17):4332-5. doi: 10.1016/j.bmcl.2014.06.071.
Epub 2014 Jul 3. PubMed PMID: 25088191.

2: Semple G, Lehmann J, Wong A, Ren A, Bruce M, Shin YJ, Sage CR, Morgan M, Chen
WC, Sebring K, Chu ZL, Leonard JN, Al-Shamma H, Grottick AJ, Du F, Liang Y,
Demarest K, Jones RM. Discovery of a second generation agonist of the orphan
G-protein coupled receptor GPR119 with an improved profile. Bioorg Med Chem Lett.
2012 Feb 15;22(4):1750-5. doi: 10.1016/j.bmcl.2011.12.092. Epub 2011 Dec 30.
PubMed PMID: 22264481.

3: Jones RM, Leonard JN, Buzard DJ, Lehmann J. GPR119 agonists for the treatment
of type 2 diabetes. Expert Opin Ther Pat. 2009 Oct;19(10):1339-59. doi:
10.1517/13543770903153878. Review. PubMed PMID: 19780700.