Bentiromide
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MedKoo CAT#: 317312

CAS#: 37106-97-1

Description: Bentiromide is a peptide used as a screening test for exocrine pancreatic insufficiency and to monitor the adequacy of supplemental pancreatic therapy. It is given by mouth as a noninvasive test. The amount of 4-aminobenzoic acid and its metabolites excreted in the urine is taken as a measure of the chymotrypsin-secreting activity of the pancreas.


Chemical Structure

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Bentiromide
CAS# 37106-97-1

Theoretical Analysis

MedKoo Cat#: 317312
Name: Bentiromide
CAS#: 37106-97-1
Chemical Formula: C23H20N2O5
Exact Mass: 404.13722
Molecular Weight: 404.42
Elemental Analysis: C, 68.31; H, 4.98; N, 6.93; O, 19.78

Price and Availability

Size Price Availability Quantity
5.0mg USD 70.0 2 weeks
10.0mg USD 80.0 2 weeks
25.0mg USD 90.0 2 weeks
50.0mg USD 120.0 2 weeks
100.0mg USD 150.0 2 weeks
200.0mg USD 250.0 2 weeks
500.0mg USD 450.0 2 weeks
1.0g USD 650.0 2 weeks
2.0g USD 950.0 2 weeks
5.0g USD 1650.0 2 weeks
10.0g USD 2650.0 2 weeks
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Synonym: Bentiromide; Bentiromido; Bentiromidum; CHEBI:31263; 37106-97-1; PFT; BTPABA; PFT

IUPAC/Chemical Name: 4-[2-benzamido-3- (4-hydroxyphenyl)- propanoyl] aminobenzoic acid

InChi Key: SPPTWHFVYKCNNK-UHFFFAOYSA-N

InChi Code: InChI=1S/C23H20N2O5/c26-19-12-6-15(7-13-19)14-20(25-21(27)16-4-2-1-3-5-16)22(28)24-18-10-8-17(9-11-18)23(29)30/h1-13,20,26H,14H2,(H,24,28)(H,25,27)(H,29,30)

SMILES Code: C1=CC=C(C=C1)C(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC3=CC=C(C=C3)C(=O)O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 404.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Egesel T, Unsal I, Dikmen G, Bayraktar Y. The assessment of pancreatic
exocrine function by bentiromide test in patients with chronic portal vein
thrombosis. Pancreas. 2002 Nov;25(4):355-9. PubMed PMID: 12409829.

2: Chung JB, Park SW, Song SY, Moon YM, Kang JK, Park IS. Comparative study of
bentiromide test and endoscopic retrograde pancreatography in patients with
chronic pancreatitis. Yonsei Med J. 1998 Feb;39(1):45-9. PubMed PMID: 9529984.

3: Oyama H, Watanabe S. [PFD test (bentiromide test, BT-PABA test)]. Nihon
Rinsho. 1997 Apr;55 Suppl 2:202-5. Review. Japanese. PubMed PMID: 9172506.

4: Durie PR, Yung-Jato LY, Soldin SJ, Verjee Z, Ellis L. Bentiromide test using
liquid-chromatographic measurement of p-aminobenzoic acid and its metabolites for
diagnosing pancreatic insufficiency in childhood. J Pediatr. 1992
Sep;121(3):413-6. PubMed PMID: 1517919.

5: Laufer D, Cleghorn G, Forstner G, Ellis L, Koren G, Durie P. The bentiromide
test using plasma p-aminobenzoic acid for diagnosing pancreatic insufficiency in
young children. The effect of two different doses and a liquid meal.
Gastroenterology. 1991 Jul;101(1):207-13. PubMed PMID: 2044909.

6: Bujanover Y, Harel A, Geter R, Blau H, Yahav J, Spirer Z. The development of
the chymotryptic activity during postnatal life using the bentiromide test. Int J
Pancreatol. 1988 Jan-Feb;3(1):53-8. PubMed PMID: 3258344.

7: Meyer BM, Campbell DR, Curington CW, Toskes PP. Bentiromide test is not
affected in patients with small bowel disease or liver disease. Pancreas.
1987;2(1):44-7. PubMed PMID: 3494995.

8: Berg JD, Chesner IM, Allen-Narker RA, Buckley BM, Lawson N. Exocrine
pancreatic function as determined in a same-day test with use of bentiromide and
p-aminosalicylic acid. Clin Chem. 1986 Jun;32(6):1010-2. PubMed PMID: 3486726.

9: Hawkins EC, Meric SM, Washabau RJ, Feldman EC, Turrel JM. Digestion of
bentiromide and absorption of xylose in healthy cats and absorption of xylose in
cats with infiltrative intestinal disease. Am J Vet Res. 1986 Mar;47(3):567-9.
PubMed PMID: 3485942.

10: Ertan A, Degertekin H, Akdamar K, Godiwala T, Mather F. A new criterion in
the assessment of bentiromide as a test of exocrine pancreatic function in
alcoholics. Pancreas. 1986;1(2):176-9. PubMed PMID: 3494993.

11: Patel VP, Jain NK, Agarwal N, GeeVarghese PJ, Pitchumoni CS. Comparison of
bentiromide test and rice flour breath hydrogen test in the detection of exocrine
pancreatic insufficiency. Pancreas. 1986;1(2):172-5. PubMed PMID: 3494992.

12: Koren G, Weizman Z, Forstner G, MacLeod SM, Durie PR. Altered PABA
pharmacokinetics in cystic fibrosis. Implications for bentiromide test. Dig Dis
Sci. 1985 Oct;30(10):928-32. PubMed PMID: 3875462.

13: Heyman MB. The bentiromide test: how good is it? Gastroenterology. 1985
Sep;89(3):685-7. PubMed PMID: 3874805.

14: Weizman Z, Forstner GG, Gaskin KJ, Kopelman H, Wong S, Durie PR. Bentiromide
test for assessing pancreatic dysfunction using analysis of para-aminobenzoic
acid in plasma and urine. Studies in cystic fibrosis and Shwachman's syndrome.
Gastroenterology. 1985 Sep;89(3):596-604. PubMed PMID: 3874804.

15: Gharbo SA, Boyer JA, Williamson MJ. Colorimetric plasma assay for the
bentiromide test (BT-PABA) for exocrine pancreatic insufficiency. Anal Biochem.
1985 Jul;148(1):228-32. PubMed PMID: 3876041.

16: Zimmer JF, Todd SE. Further evaluation of bentiromide in the diagnosis of
canine exocrine pancreatic insufficiency. Cornell Vet. 1985 Jul;75(3):426-40.
PubMed PMID: 3874751.

17: Karnes HT, Riley CM, Curry SH, Schulman SG. Analysis of
N-benzoyl-L-tyrosyl-p-aminobenzoic acid (bentiromide) metabolites in urine by
ion-pair high-performance liquid chromatography. J Chromatogr. 1985 Mar
22;338(2):377-88. PubMed PMID: 3873465.

18: Hubbard VS, Wolf RO, Lester LA, Egge AC. Diagnostic and therapeutic
applications of bentiromide screening test for exocrine pancreatic insufficiency
in patients with cystic fibrosis. Comparison with other tests of exocrine
pancreatic disease. Dig Dis Sci. 1984 Oct;29(10):881-9. PubMed PMID: 6206989.

19: Karnes HT, Bateh RP, Winefordner JD, Schulman SG. Determination of
p-aminobenzoic acid in urine by room-temperature phosphorimetry, with application
to the bentiromide test for pancreatic function. Clin Chem. 1984
Sep;30(9):1565-7. PubMed PMID: 6331913.

20: Bentiromide--a test of pancreatic insufficiency. Med Lett Drugs Ther. 1984
May 11;26(661):50. PubMed PMID: 6609300.