Bentiromide
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MedKoo CAT#: 317312

CAS#: 37106-97-1

Description: Bentiromide is a peptide used as a screening test for exocrine pancreatic insufficiency and to monitor the adequacy of supplemental pancreatic therapy. It is given by mouth as a noninvasive test. The amount of 4-aminobenzoic acid and its metabolites excreted in the urine is taken as a measure of the chymotrypsin-secreting activity of the pancreas.


Price and Availability

Size
Price

5mg
USD 70
50mg
USD 120
500mg
USD 450
5g
USD 1650
50g
Ask price
Size
Price

10mg
USD 80
100mg
USD 150
1g
USD 650
10g
USD 2650
100g
Ask price
Size
Price

25mg
USD 90
200mg
USD 250
2g
USD 950
20g
Ask price

Bentiromide,purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 317312
Name: Bentiromide
CAS#: 37106-97-1
Chemical Formula: C23H20N2O5
Exact Mass: 404.13722
Molecular Weight: 404.42
Elemental Analysis: C, 68.31; H, 4.98; N, 6.93; O, 19.78


Synonym: Bentiromide; Bentiromido; Bentiromidum; CHEBI:31263; 37106-97-1; PFT; BTPABA; PFT

IUPAC/Chemical Name: 4-[2-benzamido-3- (4-hydroxyphenyl)- propanoyl] aminobenzoic acid

InChi Key: SPPTWHFVYKCNNK-UHFFFAOYSA-N

InChi Code: InChI=1S/C23H20N2O5/c26-19-12-6-15(7-13-19)14-20(25-21(27)16-4-2-1-3-5-16)22(28)24-18-10-8-17(9-11-18)23(29)30/h1-13,20,26H,14H2,(H,24,28)(H,25,27)(H,29,30)

SMILES Code: C1=CC=C(C=C1)C(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC3=CC=C(C=C3)C(=O)O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Egesel T, Unsal I, Dikmen G, Bayraktar Y. The assessment of pancreatic
exocrine function by bentiromide test in patients with chronic portal vein
thrombosis. Pancreas. 2002 Nov;25(4):355-9. PubMed PMID: 12409829.

2: Chung JB, Park SW, Song SY, Moon YM, Kang JK, Park IS. Comparative study of
bentiromide test and endoscopic retrograde pancreatography in patients with
chronic pancreatitis. Yonsei Med J. 1998 Feb;39(1):45-9. PubMed PMID: 9529984.

3: Oyama H, Watanabe S. [PFD test (bentiromide test, BT-PABA test)]. Nihon
Rinsho. 1997 Apr;55 Suppl 2:202-5. Review. Japanese. PubMed PMID: 9172506.

4: Durie PR, Yung-Jato LY, Soldin SJ, Verjee Z, Ellis L. Bentiromide test using
liquid-chromatographic measurement of p-aminobenzoic acid and its metabolites for
diagnosing pancreatic insufficiency in childhood. J Pediatr. 1992
Sep;121(3):413-6. PubMed PMID: 1517919.

5: Laufer D, Cleghorn G, Forstner G, Ellis L, Koren G, Durie P. The bentiromide
test using plasma p-aminobenzoic acid for diagnosing pancreatic insufficiency in
young children. The effect of two different doses and a liquid meal.
Gastroenterology. 1991 Jul;101(1):207-13. PubMed PMID: 2044909.

6: Bujanover Y, Harel A, Geter R, Blau H, Yahav J, Spirer Z. The development of
the chymotryptic activity during postnatal life using the bentiromide test. Int J
Pancreatol. 1988 Jan-Feb;3(1):53-8. PubMed PMID: 3258344.

7: Meyer BM, Campbell DR, Curington CW, Toskes PP. Bentiromide test is not
affected in patients with small bowel disease or liver disease. Pancreas.
1987;2(1):44-7. PubMed PMID: 3494995.

8: Berg JD, Chesner IM, Allen-Narker RA, Buckley BM, Lawson N. Exocrine
pancreatic function as determined in a same-day test with use of bentiromide and
p-aminosalicylic acid. Clin Chem. 1986 Jun;32(6):1010-2. PubMed PMID: 3486726.

9: Hawkins EC, Meric SM, Washabau RJ, Feldman EC, Turrel JM. Digestion of
bentiromide and absorption of xylose in healthy cats and absorption of xylose in
cats with infiltrative intestinal disease. Am J Vet Res. 1986 Mar;47(3):567-9.
PubMed PMID: 3485942.

10: Ertan A, Degertekin H, Akdamar K, Godiwala T, Mather F. A new criterion in
the assessment of bentiromide as a test of exocrine pancreatic function in
alcoholics. Pancreas. 1986;1(2):176-9. PubMed PMID: 3494993.

11: Patel VP, Jain NK, Agarwal N, GeeVarghese PJ, Pitchumoni CS. Comparison of
bentiromide test and rice flour breath hydrogen test in the detection of exocrine
pancreatic insufficiency. Pancreas. 1986;1(2):172-5. PubMed PMID: 3494992.

12: Koren G, Weizman Z, Forstner G, MacLeod SM, Durie PR. Altered PABA
pharmacokinetics in cystic fibrosis. Implications for bentiromide test. Dig Dis
Sci. 1985 Oct;30(10):928-32. PubMed PMID: 3875462.

13: Heyman MB. The bentiromide test: how good is it? Gastroenterology. 1985
Sep;89(3):685-7. PubMed PMID: 3874805.

14: Weizman Z, Forstner GG, Gaskin KJ, Kopelman H, Wong S, Durie PR. Bentiromide
test for assessing pancreatic dysfunction using analysis of para-aminobenzoic
acid in plasma and urine. Studies in cystic fibrosis and Shwachman's syndrome.
Gastroenterology. 1985 Sep;89(3):596-604. PubMed PMID: 3874804.

15: Gharbo SA, Boyer JA, Williamson MJ. Colorimetric plasma assay for the
bentiromide test (BT-PABA) for exocrine pancreatic insufficiency. Anal Biochem.
1985 Jul;148(1):228-32. PubMed PMID: 3876041.

16: Zimmer JF, Todd SE. Further evaluation of bentiromide in the diagnosis of
canine exocrine pancreatic insufficiency. Cornell Vet. 1985 Jul;75(3):426-40.
PubMed PMID: 3874751.

17: Karnes HT, Riley CM, Curry SH, Schulman SG. Analysis of
N-benzoyl-L-tyrosyl-p-aminobenzoic acid (bentiromide) metabolites in urine by
ion-pair high-performance liquid chromatography. J Chromatogr. 1985 Mar
22;338(2):377-88. PubMed PMID: 3873465.

18: Hubbard VS, Wolf RO, Lester LA, Egge AC. Diagnostic and therapeutic
applications of bentiromide screening test for exocrine pancreatic insufficiency
in patients with cystic fibrosis. Comparison with other tests of exocrine
pancreatic disease. Dig Dis Sci. 1984 Oct;29(10):881-9. PubMed PMID: 6206989.

19: Karnes HT, Bateh RP, Winefordner JD, Schulman SG. Determination of
p-aminobenzoic acid in urine by room-temperature phosphorimetry, with application
to the bentiromide test for pancreatic function. Clin Chem. 1984
Sep;30(9):1565-7. PubMed PMID: 6331913.

20: Bentiromide--a test of pancreatic insufficiency. Med Lett Drugs Ther. 1984
May 11;26(661):50. PubMed PMID: 6609300.