FRAX1036
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MedKoo CAT#: 407203

CAS#: 1432908-05-8

Description: FRAX1036 is a potent and selective PAK1 inhibitor. Administration of docetaxel with either FRAX1036, or PAK1 small interfering RNA oligonucleotides dramatically altered signaling to cytoskeletal-associated proteins, such as stathmin, and induced microtubule disorganization and cellular apoptosis. Live-cell imaging revealed that the duration of mitotic arrest mediated by docetaxel was significantly reduced in the presence of FRAX1036, and this was associated with increased kinetics of apoptosis.


Chemical Structure

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FRAX1036
CAS# 1432908-05-8

Theoretical Analysis

MedKoo Cat#: 407203
Name: FRAX1036
CAS#: 1432908-05-8
Chemical Formula: C28H32ClN7O
Exact Mass: 517.23569
Molecular Weight: 518.062
Elemental Analysis: C, 64.92; H, 6.23; Cl, 6.84; N, 18.93; O, 3.09

Price and Availability

Size Price Availability Quantity
10.0mg USD 110.0 Same day
25.0mg USD 190.0 Same day
50.0mg USD 350.0 Same day
100.0mg USD 550.0 Same day
200.0mg USD 850.0 Same day
500.0mg USD 1850.0 Same day
1.0g USD 2950.0 Same day
2.0g USD 5250.0 Same day
5.0g USD 7650.0 2 weeks
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Synonym: FRAX1036; FRAX-1036; FRAX 1036.

IUPAC/Chemical Name: 6-(2-chloro-4-(6-methylpyrazin-2-yl)phenyl)-8-ethyl-2-((2-(1-methylpiperidin-4-yl)ethyl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one

InChi Key: RYCBSFIKWACFBY-UHFFFAOYSA-N

InChi Code: InChI=1S/C28H32ClN7O/c1-4-36-26-21(16-32-28(34-26)31-10-7-19-8-11-35(3)12-9-19)13-23(27(36)37)22-6-5-20(14-24(22)29)25-17-30-15-18(2)33-25/h5-6,13-17,19H,4,7-12H2,1-3H3,(H,31,32,34)

SMILES Code: O=C1C(C2=CC=C(C3=NC(C)=CN=C3)C=C2Cl)=CC4=CN=C(NCCC5CCN(C)CC5)N=C4N1CC

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 518.062 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Mortazavi F, Lu J, Phan R, Lewis M, Trinidad K, Aljilani A, Pezeshkpour G,
Tamanoi F. Significance of KRAS/PAK1/Crk pathway in non-small cell lung cancer
oncogenesis. BMC Cancer. 2015 May 9;15:381. doi: 10.1186/s12885-015-1360-4.
PubMed PMID: 25956913; PubMed Central PMCID: PMC4477307.

2: Ong CC, Gierke S, Pitt C, Sagolla M, Cheng CK, Zhou W, Jubb AM, Strickland L,
Schmidt M, Duron SG, Campbell DA, Zheng W, Dehdashti S, Shen M, Yang N, Behnke
ML, Huang W, McKew JC, Chernoff J, Forrest WF, Haverty PM, Chin SF, Rakha EA,
Green AR, Ellis IO, Caldas C, O'Brien T, Friedman LS, Koeppen H, Rudolph J,
Hoeflich KP. Small molecule inhibition of group I p21-activated kinases in breast
cancer induces apoptosis and potentiates the activity of microtubule stabilizing
agents. Breast Cancer Res. 2015 Apr 23;17:59. doi: 10.1186/s13058-015-0564-5.
PubMed PMID: 25902869; PubMed Central PMCID: PMC4445529.

FRAX1036

10.0mg / USD 110.0