JNJ-42165279
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 522477

CAS#: 1346528-50-4 (free base); 1346528-52-6 (mono HCl salt); 1346528-51-5 (2HCl salt)

Description: JNJ-42165279 is a potent and selective fatty acid amide hydrolase (FAAH) inhibitor. JNJ-42165279 covalently inactivates the FAAH enzyme, but is highly selective with regard to other enzymes, ion channels, transporters, and receptors. JNJ-42165279 exhibited excellent ADME and pharmacodynamic properties as evidenced by its ability to block FAAH in the brain and periphery of rats and thereby cause an elevation of the concentrations of anandamide (AEA), oleoylethanolamide (OEA), and palmitoyl ethanolamide (PEA). JNJ-42165279 was also efficacious in the spinal nerve ligation (SNL) model of neuropathic pain. JNJ-42165279 is currently under clinical trials.


Price and Availability

Size Price Shipping out time Quantity
100mg USD 1350 2 Weeks
200mg USD 2150 2 Weeks
500mg USD 2950 2 Weeks
1g USD 3650 2 Weeks
2g USD 4250 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-10-28. Prices are subject to change without notice.

JNJ-42165279, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 522477
Name: JNJ-42165279
CAS#: 1346528-50-4 (free base); 1346528-52-6 (mono HCl salt); 1346528-51-5 (2HCl salt)
Chemical Formula: C18H17ClF2N4O3
Exact Mass: 410.09572
Molecular Weight: 410.81
Elemental Analysis: C, 52.63; H, 4.17; Cl, 8.63; F, 9.25; N, 13.64; O, 11.68


Synonym: JNJ-42165279; JNJ 42165279; JNJ42165279.

IUPAC/Chemical Name: N-(4-chloropyridin-3-yl)-4-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)methyl)piperazine-1-carboxamide

InChi Key: YWGYNGCRVZLMCS-UHFFFAOYSA-N

InChi Code: InChI=1S/C18H17ClF2N4O3/c19-13-3-4-22-10-14(13)23-17(26)25-7-5-24(6-8-25)11-12-1-2-15-16(9-12)28-18(20,21)27-15/h1-4,9-10H,5-8,11H2,(H,23,26)

SMILES Code: O=C(N1CCN(CC2=CC=C(OC(F)(F)O3)C3=C2)CC1)NC4=C(Cl)C=CN=C4


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

John M. Keith,* William M. Jones, Mark Tichenor, Jing Liu, Mark Seierstad, James A. Palmer, Michael Webb, Mark Karbarz, Brian P. Scott, Sandy J. Wilson, Lin Luo, Michelle L. Wennerholm, Leon Chang, Michele Rizzolio, Raymond Rynberg, Sandra R. Chaplan, and J. Guy Breitenbucher. Preclinical Characterization of the FAAH Inhibitor JNJ-42165279, ACS Med. Chem. Lett. Articles ASAP (As Soon As Publishable), Publication Date (Web): November 2, 2015 (Letter), DOI: 10.1021/acsmedchemlett.5b00353