Azidocillin

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 317303

CAS#: 17243-38-8

Description: Azidocillin is a penicillin antibiotic similar to ampicillin. Azidocillin is a narrow-spectrum, semisynthetic penicillin derivative with antibacterial activity. Azidocillin binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall.


Chemical Structure

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Azidocillin
CAS# 17243-38-8

Theoretical Analysis

MedKoo Cat#: 317303
Name: Azidocillin
CAS#: 17243-38-8
Chemical Formula: C16H17N5O4S
Exact Mass: 375.10012
Molecular Weight: 375.4
Elemental Analysis: C, 51.19; H, 4.56; N, 18.66; O, 17.05; S, 8.54

Size Price Shipping out time Quantity
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Pricing updated 2021-03-07. Prices are subject to change without notice.

Azidocillin, purity > 98%, is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.

Synonym: Azidocillin; SPC 297 D; Brl 2534; Globacillin; Azidocilina ; Azidocilline; Azidocillinum; D-(-)-(alpha-Azidobenzyl)penicillin

IUPAC/Chemical Name: (2S,5R,6R)-6-[[(2R)-2-azido-2-phenylacetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid

InChi Key: ODFHGIPNGIAMDK-NJBDSQKTSA-N

InChi Code: InChI=1S/C16H17N5O4S/c1-16(2)11(15(24)25)21-13(23)10(14(21)26-16)18-12(22)9(19-20-17)8-6-4-3-5-7-8/h3-7,9-11,14H,1-2H3,(H,18,22)(H,24,25)/t9-,10-,11+,14-/m1/s1

SMILES Code: O=C([C@@H](C(C)(C)S[C@]1([H])[C@@H]2NC([C@H](N=[N+]=[N-])C3=CC=CC=C3)=O)N1C2=O)O

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001

Handling Instructions:

Preparing Stock Solutions

The following data is based on the product molecular weight 375.4 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Margarit F, Moreno-Dalmau J, Obach R, Peraire C, Plá-Delfina JM. Intestinal absorption kinetics of a series of aminopenicillins and azidocillin. A comparative study in the rat. Eur J Drug Metab Pharmacokinet. 1991;Spec No 3:102-7. PubMed PMID: 1820862.

2: Mignone F, Sardella ML, Leone N, Sciolla N, Vianzone M, Bona F, Ciravegna P, Martina A. [Azidocillin and streptococcal infections: pharmacokinetics and clinical aspects]. Minerva Pediatr. 1983 Jun 15;35(11):587-95. Italian. PubMed PMID: 6688654.

3: Mabeck CE. Prescription of antibacterial drugs for treatment of otitis media and upper respiratory tract infections in general practice in Denmark. Acta Otolaryngol. 1982 Jan-Feb;93(1-2):69-72. PubMed PMID: 7064698.

4: Gonschewski HH, Stempel G. [Treatment of chronic bronchitis with azidocillin and co-trimoxazole]. Fortschr Med. 1981 Mar 12;99(10):357-60. German. PubMed PMID: 6971244.

5: Axelsson A, Jensen C, Melin O, Singer F, von Sydow C. Treatment of acute maxillary sinusitis. V. Amoxicillin azidocillin, phenylpropanolamine and pivampicillin. Acta Otolaryngol. 1981 Mar-Apr;91(3-4):313-8. PubMed PMID: 6894819.

6: Bystedt H, Nord CE, Nordenram A. Effect of azidocillin, erythromycin, clindamycin and doxycycline on postoperative complications after surgical removal of impacted mandibular third molars. Int J Oral Surg. 1980 Jun;9(3):157-65. PubMed PMID: 6777314.

7: Wieser O, Weuta H. Azidocillin in acute attacks of chronic bronchitis. Comparisons of b.i.d. and t.i.d. administration. Br J Clin Pract. 1980 Apr;34(4):101-6. PubMed PMID: 6893157.