Atracurium Besilate

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 317259

CAS#: 64228-81-5

Description: Atracurium Besilate is a neuromuscular-blocking drug or skeletal muscle relaxant in the category of non-depolarizing neuromuscular-blocking drugs, used adjunctively in anesthesia to facilitate endotracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation. Atracurium is classified as an intermediate-duration non-depolarizing neuromuscular-blocking agent.

Chemical Structure

Atracurium Besilate
CAS# 64228-81-5

Theoretical Analysis

MedKoo Cat#: 317259
Name: Atracurium Besilate
CAS#: 64228-81-5
Chemical Formula: C59H78N2O15S2+
Exact Mass:
Molecular Weight: 1087.32
Elemental Analysis: C, 65.17; H, 7.23; N, 2.58; O, 22.07; S, 2.95

Price and Availability

Size Price Availability Quantity
5.0mg USD 70.0 2 Weeks
10.0mg USD 80.0 2 Weeks
25.0mg USD 90.0 2 Weeks
50.0mg USD 120.0 2 Weeks
100.0mg USD 150.0 2 Weeks
200.0mg USD 250.0 2 Weeks
Bulk inquiry

Synonym: 33 A 74; A 74, 33; Atracurium; Atracurium Besilate; Atracurium Besylate; Atracurium Dibesylate; Besilate, Atracurium; BW 33A; BW-33A; BW33A; Glaxo Wellcome Brand of Atracurium Besilate; Pisa Brand of Atracurium Besilate; Relatrac; Tracrium; Wellcome Brand of Atracurium Besilate

IUPAC/Chemical Name: benzenesulfonate;5-[3-[1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-2-ium-2-yl]propanoyloxy]pentyl 3-[1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-2-ium-2-yl]propanoate


InChi Code: InChI=1S/C53H72N2O12.C6H6O3S/c1-12-13-14-27-66-50(56)21-25-55(3)24-20-38-40(42(55)29-36-16-18-44(59-5)46(31-36)61-7)34-49(64-10)53(65-11)52(38)67-51(57)22-26-54(2)23-19-37-32-47(62-8)48(63-9)33-39(37)41(54)28-35-15-17-43(58-4)45(30-35)60-6;7-10(8,9)6-4-2-1-3-5-6/h15-18,30-34,41-42H,12-14,19-29H2,1-11H3;1-5H,(H,7,8,9)/q+2;

SMILES Code: O=C(OCCCCC)CC[N+]1(C)C(CC2=CC=C(OC)C(OC)=C2)C3=C(C(OC(CC[N+]4(C)C(CC5=CC=C(OC)C(OC)=C5)C6=C(C=C(OC)C(OC)=C6)CC4)=O)=C(OC)C(OC)=C3)CC1.O=S(C7=CC=CC=C7)(O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 1087.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Ramaswamy AH, Kurdi MS, Sindhupriya. TIVA-A Promising Approach to Anaesthetic
Management of Montgomery T-tube Insertion. J Clin Diagn Res. 2015
Aug;9(8):UD03-4. doi: 10.7860/JCDR/2015/13563.6395. Epub 2015 Aug 1. PubMed PMID:
26436024; PubMed Central PMCID: PMC4576618.

2: Pandey RK, Subramanium RK, Darlong V, Lekha C, Garg R, Punj J, Rewari V,
Bajpai M. Evaluation of glottic view through Air-Q Intubating Laryngeal Airway in
the supine and lateral position and assessing it as a conduit for blind
endotracheal intubation in children in the supine position. Paediatr Anaesth.
2015 Dec;25(12):1241-7. doi: 10.1111/pan.12746. Epub 2015 Sep 29. PubMed PMID:

3: Batistaki C, Tentes P, Deligiannidi P, Karakosta A, Florou P, Kostopanagiotou
G. Residual neuromuscular blockade in a real life clinical setting. Correlation
with sugammadex or neostigmine administration. Minerva Anestesiol. 2015 Sep 22.
[Epub ahead of print] PubMed PMID: 26394365.

4: Jain D, Ghai B, Bala I, Gandhi K, Banerjee G. Evaluation of I-gel(™) airway in
different head and neck positions in anesthetized paralyzed children. Paediatr
Anaesth. 2015 Dec;25(12):1248-53. doi: 10.1111/pan.12748. Epub 2015 Sep 18.
PubMed PMID: 26383088.

5: Sudré EC, de Batista PR, Castiglia YM. Longer Immediate Recovery Time After
Anesthesia Increases Risk of Respiratory Complications After Laparotomy for
Bariatric Surgery: a Randomized Clinical Trial and a Cohort Study. Obes Surg.
2015 Nov;25(11):2205-12. doi: 10.1007/s11695-015-1855-8. PubMed PMID: 26374138.

6: Locks Gde F, Cavalcanti IL, Duarte NM, da Cunha RM, de Almeida MC. Use of
neuromuscular blockers in Brazil. Braz J Anesthesiol. 2015 Sep-Oct;65(5):319-25.
doi: 10.1016/j.bjane.2015.03.001. Epub 2015 Aug 15. PubMed PMID: 26323727.

7: Yoo YC, Kim NY, Shin S, Choi YD, Hong JH, Kim CY, Park H, Bai SJ. The
Intraocular Pressure under Deep versus Moderate Neuromuscular Blockade during
Low-Pressure Robot Assisted Laparoscopic Radical Prostatectomy in a Randomized
Trial. PLoS One. 2015 Aug 28;10(8):e0135412. doi: 10.1371/journal.pone.0135412.
eCollection 2015. PubMed PMID: 26317357; PubMed Central PMCID: PMC4552736.

8: Dewachter P, Mouton-Faivre C. Anaphylaxis incidence with rocuronium,
succinylcholine, and atracurium: how risk communication can influence behavior.
Anesthesiology. 2015 Sep;123(3):735-6. doi: 10.1097/ALN.0000000000000775. PubMed
PMID: 26284871.

9: Darlong V, Garg R, Pandey R, Khokhar S, Chandralekha, Sinha R, Punj J, Sinha
R. Evaluation of minimal dose of atracurium for cataract surgery in children: A
prospective randomized double-blind study. Saudi J Anaesth. 2015
Jul-Sep;9(3):283-8. doi: 10.4103/1658-354X.154711. PubMed PMID: 26240547; PubMed
Central PMCID: PMC4478821.

10: Locks Gde F, Cavalcanti IL, Duarte NM, Cunha RM, Almeida MC. [Use of
neuromuscular blockers in Brazil]. Rev Bras Anestesiol. 2015
Sep-Oct;65(5):319-25. doi: 10.1016/j.bjan.2015.03.001. Epub 2015 Jul 6.
Portuguese. PubMed PMID: 26160168.

11: Dębska M, Szymkiewicz-Dangel J, Koleśnik A, Kretowicz P, Rebizant B, Witwicki
J, Dębski R. [Fetal cardiac interventions - are we ready for them?]. Ginekol Pol.
2015 Apr;86(4):280-6. Polish. PubMed PMID: 26117987.

12: Marshall SD, Boden E, Serpell J. The effect of routine reversal of
neuromuscular blockade on adequacy of recurrent laryngeal nerve stimulation
during thyroid surgery. Anaesth Intensive Care. 2015 Jul;43(4):485-9. PubMed
PMID: 26099761.

13: Refaat AI, Hedaya MS, Ezzat HM, Fayed MM, Salama AF, Helmy AH. Randomized
clinical trial comparing two different techniques of local anesthesia
(subcutaneous versus subcutaneous & deep infiltration) for postoperative pain in
patients undergoing open appendecectomy. J Egypt Soc Parasitol. 2015
Apr;45(1):177-82. PubMed PMID: 26012232.

14: Zuche H, Morinello E, Viestenz A, Fiorentzis MF, Volk T, Seitz B, Viestenz A.
[The Effect of Non-Depolarising Muscle Relaxants on Ocular Pulse Amplitude and
Intraocular Pressure]. Klin Monbl Augenheilkd. 2015 May 21. [Epub ahead of print]
German. PubMed PMID: 25997093.

15: Galluzzi F, De Rensis F, Saleri R, Spattini G. Effect of urethral infusion of
atracurium besylate on manual bladder expression in dogs and cats with spinal
cord injuries: a randomised trial. Vet Rec. 2015 May 23;176(21):545. doi:
10.1136/vr.102825. Epub 2015 Apr 28. PubMed PMID: 25920417.

16: Berroa F, Lafuente A, Javaloyes G, Cabrera-Freitag P, de la Borbolla JM,
Moncada R, Goikoetxea MJ, Sanz ML, Ferrer M, Gastaminza G. The incidence of
perioperative hypersensitivity reactions: a single-center, prospective, cohort
study. Anesth Analg. 2015 Jul;121(1):117-23. doi: 10.1213/ANE.0000000000000776.
PubMed PMID: 25902325.

17: Das W, Bhattacharya S, Ghosh S, Saha S, Mallik S, Pal S. Comparison between
general anesthesia and spinal anesthesia in attenuation of stress response in
laparoscopic cholecystectomy: A randomized prospective trial. Saudi J Anaesth.
2015 Apr-Jun;9(2):184-8. doi: 10.4103/1658-354X.152881. PubMed PMID: 25829908;
PubMed Central PMCID: PMC4374225.

18: Banerjee A, Das B, Mukherjee D, Khanra M. A study of the effect of caudal
epidural block on bispectral index targeted propofol requirement in children: A
comparative study. J Indian Assoc Pediatr Surg. 2015 Apr-Jun;20(2):77-81. doi:
10.4103/0971-9261.151551. PubMed PMID: 25829671; PubMed Central PMCID:

19: Eftekhari J, Kazemi Haki B, Tizro P, Alizadeh V. A comparison to facilitate
insertion of the laryngeal mask: term of recovery and postoperative nausea and
vomiting after anesthesia with propofol- atracurium and thiopental-atracurium.
Acta Med Iran. 2015;53(2):117-21. PubMed PMID: 25725181.

20: Patel TK, Patel PB, Barvaliya MJ, Tripathi CB. Drug-induced anaphylactic
reactions in Indian population: A systematic review. Indian J Crit Care Med. 2014
Dec;18(12):796-806. doi: 10.4103/0972-5229.146313. PubMed PMID: 25538414; PubMed
Central PMCID: PMC4271279.