WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 319503

CAS#: 412950-08-4

Description: Rilapladib, aslo known as SB-659032 and GTPL7376, is a lipoprotein-associated phospholipase A2 inhibitor.

Chemical Structure

CAS# 412950-08-4

Theoretical Analysis

MedKoo Cat#: 319503
Name: Rilapladib
CAS#: 412950-08-4
Chemical Formula: C40H38F5N3O3S
Exact Mass: 735.2554
Molecular Weight: 735.81402
Elemental Analysis: C, 65.29; H, 5.21; F, 12.91; N, 5.71; O, 6.52; S, 4.36

Size Price Shipping out time Quantity
Inquire bulk and customized quantity

Pricing updated 2021-03-04. Prices are subject to change without notice.

Rilapladib is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to to inquire quote.

Synonym: SB-659032; SB659032; SB 659032; GTPL7376; GTPL-7376; GTPL 7376; D05728; Rilapladib

IUPAC/Chemical Name: 2-[2-[(2,3-difluorophenyl)methylsulfanyl]-4-oxoquinolin-1-yl]-N-[1-(2-methoxyethyl)piperidin-4-yl]-N-[[4-[4-(trifluoromethyl)phenyl]phenyl]methyl]acetamide


InChi Code: InChI=1S/C40H38F5N3O3S/c1-51-22-21-46-19-17-32(18-20-46)47(24-27-9-11-28(12-10-27)29-13-15-31(16-14-29)40(43,44)45)37(50)25-48-35-8-3-2-6-33(35)36(49)23-38(48)52-26-30-5-4-7-34(41)39(30)42/h2-16,23,32H,17-22,24-26H2,1H3


Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:

Handling Instructions:

Preparing Stock Solutions

The following data is based on the product molecular weight 735.81402 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

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Dilution Calculator

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1: Shaddinger BC, Xu Y, Roger JH, Macphee CH, Handel M, Baidoo CA, Magee M,
Lepore JJ, Sprecher DL. Platelet aggregation unchanged by lipoprotein-associated
phospholipase A₂ inhibition: results from an in vitro study and two randomized
phase I trials. PLoS One. 2014 Jan 27;9(1):e83094. doi:
10.1371/journal.pone.0083094. eCollection 2014. PubMed PMID: 24475026; PubMed
Central PMCID: PMC3903475.

2: Tawakol A, Singh P, Rudd JH, Soffer J, Cai G, Vucic E, Brannan SP, Tarka EA,
Shaddinger BC, Sarov-Blat L, Matthews P, Subramanian S, Farkouh M, Fayad ZA.
Effect of treatment for 12 weeks with rilapladib, a lipoprotein-associated
phospholipase A2 inhibitor, on arterial inflammation as assessed with
18F-fluorodeoxyglucose-positron emission tomography imaging. J Am Coll Cardiol.
2014 Jan 7-14;63(1):86-8. doi: 10.1016/j.jacc.2013.07.050. Epub 2013 Aug 21.
PubMed PMID: 23973698.