Lorediplon
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MedKoo CAT#: 317148

CAS#: 917393-39-6

Description: Lorediplon is a nonbenzodiazepine of the pyrazolopyrimidine family that is being pursued as a treatment for insomnia but has not completed development. Lorediplon demonstrated a dose-dependent improvement in sleep, whereas zolpidem showed a more sustained WASO effect. No next-day hangover effects were observed. These sleep effects are also consistent with the pharmacokinetic profile of lorediplon. These results warrant clinical trials in patients with insomnia.


Chemical Structure

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Lorediplon
CAS# 917393-39-6

Theoretical Analysis

MedKoo Cat#: 317148
Name: Lorediplon
CAS#: 917393-39-6
Chemical Formula: C20H15FN4O2S
Exact Mass: 394.08997
Molecular Weight: 394.42
Elemental Analysis: C, 60.90; H, 3.83; F, 4.82; N, 14.21; O, 8.11; S, 8.13

Price and Availability

Size Price Availability Quantity
10.0mg USD 120.0 2 Weeks
25.0mg USD 150.0 2 Weeks
50.0mg USD 250.0 2 Weeks
100.0mg USD 450.0 2 Weeks
200.0mg USD 850.0 2 Weeks
500.0mg USD 1650.0 2 Weeks
1.0g USD 2650.0 2 Weeks
2.0g USD 3950.0 2 Weeks
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Synonym: Lorediplon

IUPAC/Chemical Name: N-[2-fluoro-5-[3-(thiophene-2-carbonyl)pyrazolo[1,5-a]pyrimidin-7-yl]phenyl]-N-methylacetamide

InChi Key: NQPOCLFSADOXBR-UHFFFAOYSA-N

InChi Code: InChI=1S/C20H15FN4O2S/c1-12(26)24(2)17-10-13(5-6-15(17)21)16-7-8-22-20-14(11-23-25(16)20)19(27)18-4-3-9-28-18/h3-11H,1-2H3

SMILES Code: CC(N(C1=CC(C2=CC=NC3=C(C(C4=CC=CS4)=O)C=NN23)=CC=C1F)C)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 394.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Zisapel N. Current Phase II investigational therapies for insomnia. Expert
Opin Investig Drugs. 2015 Mar;24(3):401-11. doi: 10.1517/13543784.2015.987340.
Epub 2014 Nov 25. Review. PubMed PMID: 25423562.

2: Horoszok L, Baleeiro T, D'Aniello F, Gropper S, Santos B, Guglietta A, Roth T.
A single-dose, randomized, double-blind, double dummy, placebo and
positive-controlled, five-way cross-over study to assess the pharmacodynamic
effects of lorediplon in a phase advance model of insomnia in healthy Caucasian
adult male subjects. Hum Psychopharmacol. 2014 May;29(3):266-73. doi:
10.1002/hup.2395. PubMed PMID: 24911577.