WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 317148
Description: Lorediplon is a nonbenzodiazepine of the pyrazolopyrimidine family that is being pursued as a treatment for insomnia but has not completed development. Lorediplon demonstrated a dose-dependent improvement in sleep, whereas zolpidem showed a more sustained WASO effect. No next-day hangover effects were observed. These sleep effects are also consistent with the pharmacokinetic profile of lorediplon. These results warrant clinical trials in patients with insomnia.
MedKoo Cat#: 317148
Chemical Formula: C20H15FN4O2S
Exact Mass: 394.08997
Molecular Weight: 394.42
Elemental Analysis: C, 60.90; H, 3.83; F, 4.82; N, 14.21; O, 8.11; S, 8.13
Lorediplon, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.
IUPAC/Chemical Name: N-[2-fluoro-5-[3-(thiophene-2-carbonyl)pyrazolo[1,5-a]pyrimidin-7-yl]phenyl]-N-methylacetamide
InChi Key: NQPOCLFSADOXBR-UHFFFAOYSA-N
InChi Code: InChI=1S/C20H15FN4O2S/c1-12(26)24(2)17-10-13(5-6-15(17)21)16-7-8-22-20-14(11-23-25(16)20)19(27)18-4-3-9-28-18/h3-11H,1-2H3
SMILES Code: CC(N(C1=CC(C2=CC=NC3=C(C(C4=CC=CS4)=O)C=NN23)=CC=C1F)C)=O
The following data is based on the product molecular weight 394.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Zisapel N. Current Phase II investigational therapies for insomnia. Expert
Opin Investig Drugs. 2015 Mar;24(3):401-11. doi: 10.1517/13543784.2015.987340.
Epub 2014 Nov 25. Review. PubMed PMID: 25423562.
2: Horoszok L, Baleeiro T, D'Aniello F, Gropper S, Santos B, Guglietta A, Roth T.
A single-dose, randomized, double-blind, double dummy, placebo and
positive-controlled, five-way cross-over study to assess the pharmacodynamic
effects of lorediplon in a phase advance model of insomnia in healthy Caucasian
adult male subjects. Hum Psychopharmacol. 2014 May;29(3):266-73. doi:
10.1002/hup.2395. PubMed PMID: 24911577.