Alda-1
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 522470

CAS#: 349438-38-6

Description: Alda-1 is a potent and selective Aldehyde Dehydrogenase-2 Agonist. Alda-1 reverses alcohol-induced hepatic steatosis and cell death in mice. Alda-1 inhibits atherosclerosis and attenuates hepatic steatosis in apolipoprotein E-knockout mice. Alda-1 reduces cerebral ischemia/reperfusion injury in rat through clearance of reactive aldehydes. Pharmacological activation of ALDH2 by Alda-1 reversed alcoholic steatosis and apoptosis through accelerating aldehyde clearance. This study indicates that ALDH2 is a promising molecular target and Alda-1 has therapeutic potential for treating alcoholic liver disease.


Chemical Structure

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Alda-1
CAS# 349438-38-6

Theoretical Analysis

MedKoo Cat#: 522470
Name: Alda-1
CAS#: 349438-38-6
Chemical Formula: C15H11Cl2NO3
Exact Mass: 323.0116
Molecular Weight: 324.16
Elemental Analysis: C, 55.58; H, 3.42; Cl, 21.87; N, 4.32; O, 14.81

Size Price Shipping out time Quantity
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Pricing updated 2021-03-04. Prices are subject to change without notice.

Alda-1, is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.

Synonym: Alda-1; Alda1; Alda 1.

IUPAC/Chemical Name: N-(1,3-Benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide

InChi Key: NMKJFZCBCIUYHI-UHFFFAOYSA-N

InChi Code: InChI=1S/C15H11Cl2NO3/c16-10-2-1-3-11(17)14(10)15(19)18-7-9-4-5-12-13(6-9)21-8-20-12/h1-6H,7-8H2,(H,18,19)

SMILES Code: O=C(NCC1=CC=C(OCO2)C2=C1)C3=C(Cl)C=CC=C3Cl

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001

Handling Instructions:

Preparing Stock Solutions

The following data is based on the product molecular weight 324.16 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Stachowicz A, Głombik K, Olszanecki R, Basta-Kaim A, Suski M, Lasoń W, Korbut R. The impact of mitochondrial aldehyde dehydrogenase (ALDH2) activation by Alda-1 on the behavioral and biochemical disturbances in animal model of depression. Brain Behav Immun. 2015 Aug 4. pii: S0889-1591(15)00428-6. doi: 10.1016/j.bbi.2015.08.004. [Epub ahead of print] PubMed PMID: 26254233.

2: Ikeda T, Takahashi T, Tsujita M, Kanazawa M, Toriyabe M, Koyama M, Itoh K, Nakada T, Nishizawa M, Shimohata T. Effects of Alda-1, an Aldehyde Dehydrogenase-2 Agonist, on Hypoglycemic Neuronal Death. PLoS One. 2015 Jun 17;10(6):e0128844. doi: 10.1371/journal.pone.0128844. eCollection 2015. PubMed PMID: 26083658; PubMed Central PMCID: PMC4471358.

3: Zhong W, Zhang W, Li Q, Xie G, Sun Q, Sun X, Tan X, Sun X, Jia W, Zhou Z. Pharmacological activation of aldehyde dehydrogenase 2 by Alda-1 reverses alcohol-induced hepatic steatosis and cell death in mice. J Hepatol. 2015 Jun;62(6):1375-81. doi: 10.1016/j.jhep.2014.12.022. Epub 2014 Dec 24. PubMed PMID: 25543082.

4: Gomes KM, Bechara LR, Lima VM, Ribeiro MA, Campos JC, Dourado PM, Kowaltowski AJ, Mochly-Rosen D, Ferreira JC. Aldehydic load and aldehyde dehydrogenase 2 profile during the progression of post-myocardial infarction cardiomyopathy: benefits of Alda-1. Int J Cardiol. 2015 Jan 20;179:129-38. doi: 10.1016/j.ijcard.2014.10.140. Epub 2014 Oct 23. PubMed PMID: 25464432; PubMed Central PMCID: PMC4405147.

5: Stachowicz A, Olszanecki R, Suski M, Wiśniewska A, Totoń-Żurańska J, Madej J, Jawień J, Białas M, Okoń K, Gajda M, Głombik K, Basta-Kaim A, Korbut R. Mitochondrial aldehyde dehydrogenase activation by Alda-1 inhibits atherosclerosis and attenuates hepatic steatosis in apolipoprotein E-knockout mice. J Am Heart Assoc. 2014 Nov 12;3(6):e001329. doi: 10.1161/JAHA.114.001329. PubMed PMID: 25392542; PubMed Central PMCID: PMC4338726.

6: Fu SH, Zhang HF, Yang ZB, Li TB, Liu B, Lou Z, Ma QL, Luo XJ, Peng J. Alda-1 reduces cerebral ischemia/reperfusion injury in rat through clearance of reactive aldehydes. Naunyn Schmiedebergs Arch Pharmacol. 2014 Jan;387(1):87-94. doi: 10.1007/s00210-013-0922-8. Epub 2013 Oct 1. PubMed PMID: 24081521.

7: Ning S, Budas GR, Churchill EN, Chen CH, Knox SJ, Mochly-Rosen D. Mitigation of radiation-induced dermatitis by activation of aldehyde dehydrogenase 2 using topical alda-1 in mice. Radiat Res. 2012 Jul;178(1):69-74. Epub 2012 Mar 9. PubMed PMID: 22404739; PubMed Central PMCID: PMC3417825.

8: Perez-Miller S, Younus H, Vanam R, Chen CH, Mochly-Rosen D, Hurley TD. Alda-1 is an agonist and chemical chaperone for the common human aldehyde dehydrogenase 2 variant. Nat Struct Mol Biol. 2010 Feb;17(2):159-64. doi: 10.1038/nsmb.1737. Epub 2010 Jan 10. PubMed PMID: 20062057; PubMed Central PMCID: PMC2857674.

9: Beretta M, Gorren AC, Wenzl MV, Weis R, Russwurm M, Koesling D, Schmidt K, Mayer B. Characterization of the East Asian variant of aldehyde dehydrogenase-2: bioactivation of nitroglycerin and effects of Alda-1. J Biol Chem. 2010 Jan 8;285(2):943-52. doi: 10.1074/jbc.M109.014548. Epub 2009 Nov 11. PubMed PMID: 19906643; PubMed Central PMCID: PMC2801295.