WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 317163
CAS#: 66734-13-2
Description: Alclometasone is synthetic glucocorticoid steroid for topical use in dermatology as anti-inflammatory, antipruritic, antiallergic, antiproliferative and vasoconstrictive agent. The prodrug alclometasone dipropionate is marketed as Aclovate by GlaxoSmithKline.
MedKoo Cat#: 317163
Name: Alclometasone dipropionate
CAS#: 66734-13-2
Chemical Formula: C28H37ClO7
Exact Mass: 520.22278
Molecular Weight: 521.05
Elemental Analysis: C, 64.54; H, 7.16; Cl, 6.80; O, 21.49
Alclometasone dipropionate purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.
Synonym: Aclovate; Alclometasone dipropionate; Almeta; Delonal; Sch 22219; Vaderm.
IUPAC/Chemical Name: (7R,9S,10R,11S,13S,14S,16R,17R)-7-chloro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-(2-(propionyloxy)acetyl)-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl propionate
InChi Key: DJHCCTTVDRAMEH-DUUJBDRPSA-N
InChi Code: InChI=1S/C28H37ClO7/c1-6-22(33)35-14-21(32)28(36-23(34)7-2)15(3)10-18-24-19(29)12-16-11-17(30)8-9-26(16,4)25(24)20(31)13-27(18,28)5/h8-9,11,15,18-20,24-25,31H,6-7,10,12-14H2,1-5H3/t15-,18+,19-,20+,24-,25+,26+,27+,28+/m1/s1
SMILES Code: CCC(=O)OCC(=O)[C@]1([C@@H](C[C@@H]2[C@@]1(C[C@@H]([C@H]3[C@H]2[C@@H](CC4=CC(=O)C=C[C@]34C)Cl)O)C)C)OC(=O)CC
The following data is based on the product molecular weight 521.05 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
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6: Boyd AS. Localized chronic cutaneous lupus erythematosus masquerading as pigmented lesions: a new clinical subset? Lupus. 2006;15(5):292-5. PubMed PMID: 16761504.
7: Ujiie H, Shimizu T, Shimizu H. Cutaneous reactions to imatinib mesylate treated by topical steroid. Am J Hematol. 2005 Mar;78(3):246. PubMed PMID: 15726597.
8: Brazzini B, Pimpinelli N. New and established topical corticosteroids in dermatology: clinical pharmacology and therapeutic use. Am J Clin Dermatol. 2002;3(1):47-58. Review. PubMed PMID: 11817968.
9: Sakuma S, Higashi Y, Sato N, Sasakawa T, Sengoku T, Ohkubo Y, Amaya T, Goto T. Tacrolimus suppressed the production of cytokines involved in atopic dermatitis by direct stimulation of human PBMC system. (Comparison with steroids). Int Immunopharmacol. 2001 Jun;1(6):1219-26. PubMed PMID: 11407316.
10: Iwakiri K, Hata M, Miura Y, Numano K, Yuge M, Sasaki E. Allergic contact dermatitis due to bendazac and alclometasone dipropionate. Contact Dermatitis. 1999 Oct;41(4):218-39. Review. PubMed PMID: 10515101.
