Alclometasone dipropionate
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 317163

CAS#: 66734-13-2

Description: Alclometasone is synthetic glucocorticoid steroid for topical use in dermatology as anti-inflammatory, antipruritic, antiallergic, antiproliferative and vasoconstrictive agent. The prodrug alclometasone dipropionate is marketed as Aclovate by GlaxoSmithKline.


Chemical Structure

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Alclometasone dipropionate
CAS# 66734-13-2

Theoretical Analysis

MedKoo Cat#: 317163
Name: Alclometasone dipropionate
CAS#: 66734-13-2
Chemical Formula: C28H37ClO7
Exact Mass: 520.22278
Molecular Weight: 521.05
Elemental Analysis: C, 64.54; H, 7.16; Cl, 6.80; O, 21.49

Size Price Shipping out time Quantity
5mg USD 250 2 Weeks
10mg USD 450 2 Weeks
25mg USD 625 2 Weeks
50mg USD 850 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2021-02-28. Prices are subject to change without notice.

Alclometasone dipropionate purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.

Synonym: Aclovate; Alclometasone dipropionate; Almeta; Delonal; Sch 22219; Vaderm.

IUPAC/Chemical Name: (7R,9S,10R,11S,13S,14S,16R,17R)-7-chloro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-(2-(propionyloxy)acetyl)-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl propionate

InChi Key: DJHCCTTVDRAMEH-DUUJBDRPSA-N

InChi Code: InChI=1S/C28H37ClO7/c1-6-22(33)35-14-21(32)28(36-23(34)7-2)15(3)10-18-24-19(29)12-16-11-17(30)8-9-26(16,4)25(24)20(31)13-27(18,28)5/h8-9,11,15,18-20,24-25,31H,6-7,10,12-14H2,1-5H3/t15-,18+,19-,20+,24-,25+,26+,27+,28+/m1/s1

SMILES Code: CCC(=O)OCC(=O)[C@]1([C@@H](C[C@@H]2[C@@]1(C[C@@H]([C@H]3[C@H]2[C@@H](CC4=CC(=O)C=C[C@]34C)Cl)O)C)C)OC(=O)CC

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001

Handling Instructions:

Preparing Stock Solutions

The following data is based on the product molecular weight 521.05 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Ulff E, Maroti M, Serup J, Falkmer U. A potent steroid cream is superior to emollients in reducing acute radiation dermatitis in breast cancer patients treated with adjuvant radiotherapy. A randomised study of betamethasone versus two moisturizing creams. Radiother Oncol. 2013 Aug;108(2):287-92. doi: 10.1016/j.radonc.2013.05.033. Epub 2013 Jul 2. PubMed PMID: 23827771.

2: Zimmerman B, Chamlin SL. A 12-year-old boy with foot lesions. Pediatr Ann. 2013 Jan;42(1):11-2. doi: 10.3928/00904481-20121221-12. PubMed PMID: 23316825.

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4: Isaksson M. Corticosteroid contact allergy--the importance of late readings and testing with corticosteroids used by the patients. Contact Dermatitis. 2007 Jan;56(1):56-7. PubMed PMID: 17177720.

5: Nakagawa H. Comparison of the efficacy and safety of 0.1% tacrolimus ointment with topical corticosteroids in adult patients with atopic dermatitis: review of randomised, double-blind clinical studies conducted in Japan. Clin Drug Investig. 2006;26(5):235-46. Review. PubMed PMID: 17163257.

6: Boyd AS. Localized chronic cutaneous lupus erythematosus masquerading as pigmented lesions: a new clinical subset? Lupus. 2006;15(5):292-5. PubMed PMID: 16761504.

7: Ujiie H, Shimizu T, Shimizu H. Cutaneous reactions to imatinib mesylate treated by topical steroid. Am J Hematol. 2005 Mar;78(3):246. PubMed PMID: 15726597.

8: Brazzini B, Pimpinelli N. New and established topical corticosteroids in dermatology: clinical pharmacology and therapeutic use. Am J Clin Dermatol. 2002;3(1):47-58. Review. PubMed PMID: 11817968.

9: Sakuma S, Higashi Y, Sato N, Sasakawa T, Sengoku T, Ohkubo Y, Amaya T, Goto T. Tacrolimus suppressed the production of cytokines involved in atopic dermatitis by direct stimulation of human PBMC system. (Comparison with steroids). Int Immunopharmacol. 2001 Jun;1(6):1219-26. PubMed PMID: 11407316.

10: Iwakiri K, Hata M, Miura Y, Numano K, Yuge M, Sasaki E. Allergic contact dermatitis due to bendazac and alclometasone dipropionate. Contact Dermatitis. 1999 Oct;41(4):218-39. Review. PubMed PMID: 10515101.