WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 407196
CAS#: 20324-87-2
Description: AMI-1 is a potent and selective arginine methyltransferase inhibitor, is also a potent scavenger of NADPH-oxidase-derived superoxide. AMI-1 can modulate nuclear receptor-regulated transcription from estrogen and androgen response elements.
MedKoo Cat#: 407196
Name: AMI-1 disodium salt
CAS#: 20324-87-2
Chemical Formula: C21H14N2Na2O9S2
Exact Mass:
Molecular Weight: 548.44754
Elemental Analysis: C, 45.99; H, 2.57; N, 5.11; Na, 8.38; O, 26.25; S, 11.69
AMI-1 disodium salt, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.
Synonym: AMI-1; AMI 1; AMI1; AMI-1 disodium salt.
IUPAC/Chemical Name: Disodium 7,7'-(carbonyldiimino)bis(4-hydroxynaphthalene-2-sulphonate)
InChi Key: MOUNHKKCIGVIDI-UHFFFAOYSA-L
InChi Code: InChI=1S/C21H16N2O9S2.2Na/c24-19-9-15(33(27,28)29)7-11-5-13(1-3-17(11)19)22-21(26)23-14-2-4-18-12(6-14)8-16(10-20(18)25)34(30,31)32;;/h1-10,24-25H,(H2,22,23,26)(H,27,28,29)(H,30,31,32);;/q;2*+1/p-2
SMILES Code: O=C(NC1=CC2=CC(S(=O)([O-])=O)=CC(O)=C2C=C1)NC3=CC4=CC(S(=O)([O-])=O)=CC(O)=C4C=C3.[Na+].[Na+]
The following data is based on the product molecular weight 548.44754 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Castellano S, Milite C, Ragno R, Simeoni S, Mai A, Limongelli V, Novellino E,
Bauer I, Brosch G, Spannhoff A, Cheng D, Bedford MT, Sbardella G. Design,
synthesis and biological evaluation of carboxy analogues of arginine
methyltransferase inhibitor 1 (AMI-1). ChemMedChem. 2010 Mar 1;5(3):398-414. doi:
10.1002/cmdc.200900459. PubMed PMID: 20091730.
2: Chen F, Fulton DJ. An inhibitor of protein arginine methyltransferases,
7,7'-carbonylbis(azanediyl)bis(4-hydroxynaphthalene-2-sulfonic acid (AMI-1), is a
potent scavenger of NADPH-oxidase-derived superoxide. Mol Pharmacol. 2010
Feb;77(2):280-7. doi: 10.1124/mol.109.061077. Epub 2009 Nov 10. PubMed PMID:
19903831; PubMed Central PMCID: PMC3202478.