AMI-1 disodium salt
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MedKoo CAT#: 407196

CAS#: 20324-87-2

Description: AMI-1 is a potent and selective arginine methyltransferase inhibitor, is also a potent scavenger of NADPH-oxidase-derived superoxide. AMI-1 can modulate nuclear receptor-regulated transcription from estrogen and androgen response elements.

Chemical Structure

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AMI-1 disodium salt
CAS# 20324-87-2
Handing Instruction

Theoretical Analysis

MedKoo Cat#: 407196
Name: AMI-1 disodium salt
CAS#: 20324-87-2
Chemical Formula: C21H14N2Na2O9S2
Exact Mass:
Molecular Weight: 548.44754
Elemental Analysis: C, 45.99; H, 2.57; N, 5.11; Na, 8.38; O, 26.25; S, 11.69

Size Price Shipping out time Quantity
Inquire bulk and customized quantity
Pricing updated 2021-02-25. Prices are subject to change without notice.

AMI-1 disodium salt, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.

Synonym: AMI-1; AMI 1; AMI1; AMI-1 disodium salt.

IUPAC/Chemical Name: Disodium 7,7'-(carbonyldiimino)bis(4-hydroxynaphthalene-2-sulphonate)

InChi Key: MOUNHKKCIGVIDI-UHFFFAOYSA-L

InChi Code: InChI=1S/C21H16N2O9S2.2Na/c24-19-9-15(33(27,28)29)7-11-5-13(1-3-17(11)19)22-21(26)23-14-2-4-18-12(6-14)8-16(10-20(18)25)34(30,31)32;;/h1-10,24-25H,(H2,22,23,26)(H,27,28,29)(H,30,31,32);;/q;2*+1/p-2

SMILES Code: O=C(NC1=CC2=CC(S(=O)([O-])=O)=CC(O)=C2C=C1)NC3=CC4=CC(S(=O)([O-])=O)=CC(O)=C4C=C3.[Na+].[Na+]

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001

Handling Instructions:
View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 548.44754 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

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1: Castellano S, Milite C, Ragno R, Simeoni S, Mai A, Limongelli V, Novellino E,
Bauer I, Brosch G, Spannhoff A, Cheng D, Bedford MT, Sbardella G. Design,
synthesis and biological evaluation of carboxy analogues of arginine
methyltransferase inhibitor 1 (AMI-1). ChemMedChem. 2010 Mar 1;5(3):398-414. doi:
10.1002/cmdc.200900459. PubMed PMID: 20091730.

2: Chen F, Fulton DJ. An inhibitor of protein arginine methyltransferases,
7,7'-carbonylbis(azanediyl)bis(4-hydroxynaphthalene-2-sulfonic acid (AMI-1), is a
potent scavenger of NADPH-oxidase-derived superoxide. Mol Pharmacol. 2010
Feb;77(2):280-7. doi: 10.1124/mol.109.061077. Epub 2009 Nov 10. PubMed PMID:
19903831; PubMed Central PMCID: PMC3202478.

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AMI-1 disodium salt