AMI-1 disodium salt

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MedKoo CAT#: 407196

CAS#: 20324-87-2

Description: AMI-1 is a potent and selective arginine methyltransferase inhibitor, is also a potent scavenger of NADPH-oxidase-derived superoxide. AMI-1 can modulate nuclear receptor-regulated transcription from estrogen and androgen response elements.

Chemical Structure

AMI-1 disodium salt
CAS# 20324-87-2

Theoretical Analysis

MedKoo Cat#: 407196
Name: AMI-1 disodium salt
CAS#: 20324-87-2
Chemical Formula: C21H14N2Na2O9S2
Exact Mass:
Molecular Weight: 548.44754
Elemental Analysis: C, 45.99; H, 2.57; N, 5.11; Na, 8.38; O, 26.25; S, 11.69

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: AMI-1; AMI 1; AMI1; AMI-1 disodium salt.

IUPAC/Chemical Name: Disodium 7,7'-(carbonyldiimino)bis(4-hydroxynaphthalene-2-sulphonate)


InChi Code: InChI=1S/C21H16N2O9S2.2Na/c24-19-9-15(33(27,28)29)7-11-5-13(1-3-17(11)19)22-21(26)23-14-2-4-18-12(6-14)8-16(10-20(18)25)34(30,31)32;;/h1-10,24-25H,(H2,22,23,26)(H,27,28,29)(H,30,31,32);;/q;2*+1/p-2

SMILES Code: O=C(NC1=CC2=CC(S(=O)([O-])=O)=CC(O)=C2C=C1)NC3=CC4=CC(S(=O)([O-])=O)=CC(O)=C4C=C3.[Na+].[Na+]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 548.44754 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Castellano S, Milite C, Ragno R, Simeoni S, Mai A, Limongelli V, Novellino E,
Bauer I, Brosch G, Spannhoff A, Cheng D, Bedford MT, Sbardella G. Design,
synthesis and biological evaluation of carboxy analogues of arginine
methyltransferase inhibitor 1 (AMI-1). ChemMedChem. 2010 Mar 1;5(3):398-414. doi:
10.1002/cmdc.200900459. PubMed PMID: 20091730.

2: Chen F, Fulton DJ. An inhibitor of protein arginine methyltransferases,
7,7'-carbonylbis(azanediyl)bis(4-hydroxynaphthalene-2-sulfonic acid (AMI-1), is a
potent scavenger of NADPH-oxidase-derived superoxide. Mol Pharmacol. 2010
Feb;77(2):280-7. doi: 10.1124/mol.109.061077. Epub 2009 Nov 10. PubMed PMID:
19903831; PubMed Central PMCID: PMC3202478.