WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 407196
CAS#: 20324-87-2
Description: AMI-1 is a potent and selective arginine methyltransferase inhibitor, is also a potent scavenger of NADPH-oxidase-derived superoxide. AMI-1 can modulate nuclear receptor-regulated transcription from estrogen and androgen response elements.
MedKoo Cat#: 407196
Name: AMI-1 disodium salt
CAS#: 20324-87-2
Chemical Formula: C21H14N2Na2O9S2
Exact Mass:
Molecular Weight: 548.44754
Elemental Analysis: C, 45.99; H, 2.57; N, 5.11; Na, 8.38; O, 26.25; S, 11.69
This product is not in stock, which may be available by custom synthesis.
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Synonym: AMI-1; AMI 1; AMI1; AMI-1 disodium salt.
IUPAC/Chemical Name: Disodium 7,7'-(carbonyldiimino)bis(4-hydroxynaphthalene-2-sulphonate)
InChi Key: MOUNHKKCIGVIDI-UHFFFAOYSA-L
InChi Code: InChI=1S/C21H16N2O9S2.2Na/c24-19-9-15(33(27,28)29)7-11-5-13(1-3-17(11)19)22-21(26)23-14-2-4-18-12(6-14)8-16(10-20(18)25)34(30,31)32;;/h1-10,24-25H,(H2,22,23,26)(H,27,28,29)(H,30,31,32);;/q;2*+1/p-2
SMILES Code: O=C(NC1=CC2=CC(S(=O)([O-])=O)=CC(O)=C2C=C1)NC3=CC4=CC(S(=O)([O-])=O)=CC(O)=C4C=C3.[Na+].[Na+]
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 548.44754 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Castellano S, Milite C, Ragno R, Simeoni S, Mai A, Limongelli V, Novellino E,
Bauer I, Brosch G, Spannhoff A, Cheng D, Bedford MT, Sbardella G. Design,
synthesis and biological evaluation of carboxy analogues of arginine
methyltransferase inhibitor 1 (AMI-1). ChemMedChem. 2010 Mar 1;5(3):398-414. doi:
10.1002/cmdc.200900459. PubMed PMID: 20091730.
2: Chen F, Fulton DJ. An inhibitor of protein arginine methyltransferases,
7,7'-carbonylbis(azanediyl)bis(4-hydroxynaphthalene-2-sulfonic acid (AMI-1), is a
potent scavenger of NADPH-oxidase-derived superoxide. Mol Pharmacol. 2010
Feb;77(2):280-7. doi: 10.1124/mol.109.061077. Epub 2009 Nov 10. PubMed PMID:
19903831; PubMed Central PMCID: PMC3202478.
