Atomoxetine HCl

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 317256

CAS#: 82248-59-7 (HCl)

Description: Atomoxetine is a norepinephrine reuptake inhibitor approved for the treatment of attention deficit hyperactivity disorder (ADHD). The brand name is Strattera. The initial therapeutic effects of atomoxetine usually take 2–4 weeks to become apparent. There has been some suggestion that atomoxetine might be a helpful adjunct in people with major depression, especially in cases where ADHD occurs comorbidly to major depression.

Chemical Structure

Atomoxetine HCl
CAS# 82248-59-7 (HCl)

Theoretical Analysis

MedKoo Cat#: 317256
Name: Atomoxetine HCl
CAS#: 82248-59-7 (HCl)
Chemical Formula: C17H22ClNO
Exact Mass: 255.16231
Molecular Weight: 291.819
Elemental Analysis: C, 69.97; H, 7.60; Cl, 12.15; N, 4.80; O, 5.48

Price and Availability

Size Price Availability Quantity
500.0mg USD 250.0 2 Weeks
1.0g USD 450.0 2 Weeks
2.0g USD 750.0 2 Weeks
5.0g USD 1450.0 2 Weeks
10.0g USD 2250.0 2 Weeks
20.0g USD 3450.0 2 Weeks
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Related CAS #: 83015-26-3 (free base)   82248-59-7 (HCl)    

Synonym: Atomoxetine; Tomoxetine; Tomoxetina; Tomoxetinum; (-)-Tomoxetine; Strattera

IUPAC/Chemical Name: (3R)-N-methyl-3-(2-methylphenoxy)-3-phenylpropan-1-amine hydrochloride


InChi Code: InChI=1S/C17H21NO.ClH/c1-14-8-6-7-11-16(14)19-17(12-13-18-2)15-9-4-3-5-10-15;/h3-11,17-18H,12-13H2,1-2H3;1H/t17-;/m1./s1


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 291.819 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Handen BL, Aman MG, Arnold LE, Hyman SL, Tumuluru RV, Lecavalier L, Corbett-Dick P, Pan X, Hollway JA, Buchan-Page KA, Silverman LB, Brown NV, Rice RR Jr, Hellings J, Mruzek DW, McAuliffe-Bellin S, Hurt EA, Ryan MM, Levato L, Smith T. Atomoxetine, Parent Training, and Their Combination in Children With Autism Spectrum Disorder and Attention-Deficit/Hyperactivity Disorder. J Am Acad Child Adolesc Psychiatry. 2015 Nov;54(11):905-915. doi: 10.1016/j.jaac.2015.08.013. Epub 2015 Sep 3. PubMed PMID: 26506581.

2: Clemow DB, Mason OW, Sarkis EH, Ruff DD, Berman BD, Donnelly CL, Robb AS, Holland DS, Schuh KJ, Barnes JM, Araujo AB. Atomoxetine monotherapy compared with combination therapy for the treatment of ADHD: a retrospective chart review study. Expert Rev Neurother. 2015 Oct 21:1-14. [Epub ahead of print] PubMed PMID: 26488905.

3: Fang Y, Ji N, Cao Q, Su Y, Chen M, Wang Y, Yang L. Variants of Dopamine Beta Hydroxylase Gene Moderate Atomoxetine Response in Children with Attention-Deficit/Hyperactivity Disorder. J Child Adolesc Psychopharmacol. 2015 Oct;25(8):625-32. doi: 10.1089/cap.2014.0178. Epub 2015 Oct 8. PubMed PMID: 26447643.

4: Chou TL, Chia S, Shang CY, Gau SS. Differential therapeutic effects of 12-week treatment of atomoxetine and methylphenidate on drug-naïve children with attention deficit/hyperactivity disorder: A counting Stroop functional MRI study. Eur Neuropsychopharmacol. 2015 Sep 8. pii: S0924-977X(15)00280-1. doi: 10.1016/j.euroneuro.2015.08.024. [Epub ahead of print] PubMed PMID: 26409297.

5: Hale GM, Brenner M. Atomoxetine for Orthostatic Hypotension in an Elderly Patient Over 10 Weeks: A Case Report. Pharmacotherapy. 2015 Sep;35(9):e141-8. doi: 10.1002/phar.1635. PubMed PMID: 26406777.

6: Lin HY, Gau SS. Atomoxetine Treatment Strengthens an Anti-Correlated Relationship between Functional Brain Networks in Medication-Naïve Adults with Attention-Deficit Hyperactivity Disorder: A Randomized Double-Blind Placebo-Controlled Clinical Trial. Int J Neuropsychopharmacol. 2015 Sep 16. pii: pyv094. doi: 10.1093/ijnp/pyv094. [Epub ahead of print] PubMed PMID: 26377368.

7: Perugi G, Vannucchi G. The use of stimulants and atomoxetine in adults with comorbid ADHD and bipolar disorder. Expert Opin Pharmacother. 2015 Oct;16(14):2193-204. doi: 10.1517/14656566.2015.1079620. PubMed PMID: 26364896.

8: Clemow DB, Bushe CJ. Atomoxetine in patients with ADHD: A clinical and pharmacological review of the onset, trajectory, duration of response and implications for patients. J Psychopharmacol. 2015 Sep 8. pii: 0269881115602489. [Epub ahead of print] Review. PubMed PMID: 26349559.

9: Stegmann B, Dörfelt A, Haen E. Quantification of Methylphenidate, Dexamphetamine and Atomoxetine in Human Serum and Oral Fluid by HPLC with Fluorescence Detection. Ther Drug Monit. 2015 Sep 2. [Epub ahead of print] PubMed PMID: 26349081.

10: Walker DJ, Mason O, Clemow DB, Day KA. Atomoxetine treatment in adults with attention-deficit/hyperactivity disorder. Postgrad Med. 2014 Sep;127(7):686-701. doi: 10.1080/00325481.2015.1081046. PubMed PMID: 26343377.

11: Yamada N, Kakuda W, Yamamoto K, Momosaki R, Abo M. Atomoxetine administration combined with intensive speech therapy for post-stroke aphasia: evaluation by a novel SPECT method. Int J Neurosci. 2015 Sep 3:1-10. [Epub ahead of print] PubMed PMID: 26335615.

12: Kabul S, Alatorre C, Montejano LB, Farr AM, Clemow DB. Real-World Dosing Patterns of Atomoxetine in Adults with Attention-Deficit/Hyperactivity Disorder. CNS Neurosci Ther. 2015 Aug 30. doi: 10.1111/cns.12442. [Epub ahead of print] PubMed PMID: 26331467.

13: Upadhyaya H, Tanaka Y, Lipsius S, Kryzhanovskaya LA, Lane JR, Escobar R, Trzepacz PT, Allen AJ. Time-to-onset and -resolution of adverse events before/after atomoxetine discontinuation in adult patients with ADHD. Postgrad Med. 2014 Sep;127(7):677-85. doi: 10.1080/00325481.2015.1083394. Epub 2015 Sep 2. PubMed PMID: 26329980.

14: Brown JT, Bishop JR. Atomoxetine pharmacogenetics: associations with pharmacokinetics, treatment response and tolerability. Pharmacogenomics. 2015 Aug;16(13):1513-20. doi: 10.2217/PGS.15.93. Epub 2015 Aug 28. PubMed PMID: 26314574.

15: Cortese S, Panei P, Arcieri R, Germinario EA, Capuano A, Margari L, Chiarotti F, Curatolo P. Safety of Methylphenidate and Atomoxetine in Children with Attention-Deficit/Hyperactivity Disorder (ADHD): Data from the Italian National ADHD Registry. CNS Drugs. 2015 Aug 21. [Epub ahead of print] PubMed PMID: 26293742.

16: Yamada N, Kakuda W, Yamamoto K, Momosaki R, Abo M. Atomoxetine administration combined with intensive speech therapy for post-stroke aphasia: Evaluation using a novel SPECT method. Int J Neurosci. 2015 Aug 13:1-28. [Epub ahead of print] PubMed PMID: 26268403.

17: Byeon JY, Kim YH, Na HS, Jang JH, Kim SH, Lee YJ, Bae JW, Kim IS, Jang CG, Chung MW, Lee SY. Effects of the CYP2D6*10 allele on the pharmacokinetics of atomoxetine and its metabolites. Arch Pharm Res. 2015 Aug 9. [Epub ahead of print] PubMed PMID: 26254792.

18: Ozbaran B, Kose S, Yuzuguldu O, Atar B, Aydin C. Combined methylphenidate and atomoxetine pharmacotherapy in attention deficit hyperactivity disorder. World J Biol Psychiatry. 2015 Jul 30:1-6. [Epub ahead of print] PubMed PMID: 26223958.

19: Shang CY, Pan YL, Lin HY, Huang LW, Gau SS. An Open-Label, Randomized Trial of Methylphenidate and Atomoxetine Treatment in Children with Attention-Deficit/Hyperactivity Disorder. J Child Adolesc Psychopharmacol. 2015 Sep;25(7):566-73. doi: 10.1089/cap.2015.0035. Epub 2015 Jul 29. PubMed PMID: 26222447.

20: Ince Tasdelen B, Karakaya E, Oztop DB. Effects of Atomoxetine and Osmotic Release Oral System-Methylphenidate on Executive Functions in Patients with Combined Type Attention-Deficit/Hyperactivity Disorder. J Child Adolesc Psychopharmacol. 2015 Aug;25(6):494-500. doi: 10.1089/cap.2014.0155. Epub 2015 Jul 28. PubMed PMID: 26218871.