Atomoxetine HCl
featured

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 317256

CAS#: 82248-59-7 (HCl)

Description: Atomoxetine is a norepinephrine reuptake inhibitor approved for the treatment of attention deficit hyperactivity disorder (ADHD). The brand name is Strattera. The initial therapeutic effects of atomoxetine usually take 2–4 weeks to become apparent. There has been some suggestion that atomoxetine might be a helpful adjunct in people with major depression, especially in cases where ADHD occurs comorbidly to major depression.

Chemical Structure

img
Atomoxetine HCl
CAS# 82248-59-7 (HCl)
Product data Instruction

Theoretical Analysis

MedKoo Cat#: 317256
Name: Atomoxetine HCl
CAS#: 82248-59-7 (HCl)
Chemical Formula: C17H22ClNO
Exact Mass: 255.16
Molecular Weight: 291.819
Elemental Analysis: C, 69.97; H, 7.60; Cl, 12.15; N, 4.80; O, 5.48

Price and Availability

Size Price Availability Quantity
500mg USD 250 2 Weeks
1g USD 450 2 Weeks
2g USD 750 2 Weeks
5g USD 1450 2 Weeks
10g USD 2250 2 Weeks
20g USD 3450 2 Weeks
Bulk inquiry

Related CAS #: 83015-26-3 (free base)   82248-59-7 (HCl)    

Synonym: Atomoxetine; Tomoxetine; Tomoxetina; Tomoxetinum; (-)-Tomoxetine; Strattera

IUPAC/Chemical Name: (3R)-N-methyl-3-(2-methylphenoxy)-3-phenylpropan-1-amine hydrochloride

InChi Key: LUCXVPAZUDVVBT-UNTBIKODSA-N

InChi Code: InChI=1S/C17H21NO.ClH/c1-14-8-6-7-11-16(14)19-17(12-13-18-2)15-9-4-3-5-10-15;/h3-11,17-18H,12-13H2,1-2H3;1H/t17-;/m1./s1

SMILES Code: CC1=CC=CC=C1O[C@@H](C2=CC=CC=C2)CCNC.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Product Data:
Product Data
Instruction:
View handling instruction
Biological target: Atomoxetine hydrochloride is a potent and selective noradrenalin re-uptake inhibitor (Ki values are 5, 77 and 1451 nM for inhibition of radioligand binding to human NET, SERT and DAT respectively).
In vitro activity: Concentration-dependence of atomoxetine-induced hERG block was analysed in a HEK cell line stably expressing hERG channels using the whole-cell patch clamp technique. From a holding potential of −80 mV, a constant test pulse to +20 mV (400 ms) was applied, followed by a return pulse to −120 mV (400 ms) to elicit large inward tail currents (Figure 3, inset). Atomoxetine, over a range of concentrations (0.1–100 µmol·L−1), reduced peak tail currents (n = 5–7, Figure 3). The dose–response curve was fitted using the Hill equation and yielded an IC50 of 6.26 ± 0.92 µmol·L−1 (nH = 0.6 ± 0.06). Reference: Br J Pharmacol. 2009 Jan; 156(2): 226–236. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2697834/
In vivo activity: The Bonferroni post hoc test revealed that there was a significant increase in the mean number of proliferating cells in the ATX (Atomoxetine)‐treated rat group compared with saline‐, DOX‐ and ATX + DOX‐treated groups (p < .001), as shown in Figure 4. Moreover, co‐administration of ATX and DOX significantly increased the mean number of Ki67 positive cells compared with the DOX‐treated group (p < .05). The saline‐treated group showed a significant increase in the mean number of Ki67 positive cells compared with the DOX‐treated one (p < .001), as shown in Figure 4. Figure 5 shows a representative image of Ki67 positive proliferating cells within the DG counter‐stained with haematoxylin stain. Reference: Vet Med Sci. 2020 Nov; 6(4): 1017–1024. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7738722/

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 62.7 214.76
DMF 30.0 102.80
Ethanol 33.5 114.80
PBS (pH 7.2) 2.0 6.85
Water 8.3 28.44

Preparing Stock Solutions

The following data is based on the product molecular weight 291.82 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol: 1. Ludolph AG, Udvardi PT, Schaz U, Henes C, Adolph O, Weigt HU, Fegert JM, Boeckers TM, Föhr KJ. Atomoxetine acts as an NMDA receptor blocker in clinically relevant concentrations. Br J Pharmacol. 2010 May;160(2):283-91. doi: 10.1111/j.1476-5381.2010.00707.x. PMID: 20423340; PMCID: PMC2874851. 2. Scherer D, Hassel D, Bloehs R, Zitron E, von Löwenstern K, Seyler C, Thomas D, Konrad F, Bürgers HF, Seemann G, Rottbauer W, Katus HA, Karle CA, Scholz EP. Selective noradrenaline reuptake inhibitor atomoxetine directly blocks hERG currents. Br J Pharmacol. 2009 Jan;156(2):226-36. doi: 10.1111/j.1476-5381.2008.00018.x. Epub 2009 Jan 16. PMID: 19154426; PMCID: PMC2697834. 3. Alamri FF, Al Shoyaib A, Syeara N, Paul A, Jayaraman S, Karamyan ST, Arumugam TV, Karamyan VT. Delayed atomoxetine or fluoxetine treatment coupled with limited voluntary running promotes motor recovery in mice after ischemic stroke. Neural Regen Res. 2021 Jul;16(7):1244-1251. doi: 10.4103/1673-5374.301031. PMID: 33318401. 4. Salman A, El Beltagy M, Shatarat A, Alzghoul L, Oweis L, Al Antary N, Al Fegie S, Mohsen M, Salman S. Atomoxetine improves hippocampal cell proliferation but not memory in Doxorubicin-treated adult male rats. Vet Med Sci. 2020 Nov;6(4):1017-1024. doi: 10.1002/vms3.276. Epub 2020 Apr 27. PMID: 32342640; PMCID: PMC7738722.
In vitro protocol: 1. Ludolph AG, Udvardi PT, Schaz U, Henes C, Adolph O, Weigt HU, Fegert JM, Boeckers TM, Föhr KJ. Atomoxetine acts as an NMDA receptor blocker in clinically relevant concentrations. Br J Pharmacol. 2010 May;160(2):283-91. doi: 10.1111/j.1476-5381.2010.00707.x. PMID: 20423340; PMCID: PMC2874851. 2. Scherer D, Hassel D, Bloehs R, Zitron E, von Löwenstern K, Seyler C, Thomas D, Konrad F, Bürgers HF, Seemann G, Rottbauer W, Katus HA, Karle CA, Scholz EP. Selective noradrenaline reuptake inhibitor atomoxetine directly blocks hERG currents. Br J Pharmacol. 2009 Jan;156(2):226-36. doi: 10.1111/j.1476-5381.2008.00018.x. Epub 2009 Jan 16. PMID: 19154426; PMCID: PMC2697834.
In vivo protocol: 1. Alamri FF, Al Shoyaib A, Syeara N, Paul A, Jayaraman S, Karamyan ST, Arumugam TV, Karamyan VT. Delayed atomoxetine or fluoxetine treatment coupled with limited voluntary running promotes motor recovery in mice after ischemic stroke. Neural Regen Res. 2021 Jul;16(7):1244-1251. doi: 10.4103/1673-5374.301031. PMID: 33318401. 2. Salman A, El Beltagy M, Shatarat A, Alzghoul L, Oweis L, Al Antary N, Al Fegie S, Mohsen M, Salman S. Atomoxetine improves hippocampal cell proliferation but not memory in Doxorubicin-treated adult male rats. Vet Med Sci. 2020 Nov;6(4):1017-1024. doi: 10.1002/vms3.276. Epub 2020 Apr 27. PMID: 32342640; PMCID: PMC7738722.

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Handen BL, Aman MG, Arnold LE, Hyman SL, Tumuluru RV, Lecavalier L, Corbett-Dick P, Pan X, Hollway JA, Buchan-Page KA, Silverman LB, Brown NV, Rice RR Jr, Hellings J, Mruzek DW, McAuliffe-Bellin S, Hurt EA, Ryan MM, Levato L, Smith T. Atomoxetine, Parent Training, and Their Combination in Children With Autism Spectrum Disorder and Attention-Deficit/Hyperactivity Disorder. J Am Acad Child Adolesc Psychiatry. 2015 Nov;54(11):905-915. doi: 10.1016/j.jaac.2015.08.013. Epub 2015 Sep 3. PubMed PMID: 26506581.

2: Clemow DB, Mason OW, Sarkis EH, Ruff DD, Berman BD, Donnelly CL, Robb AS, Holland DS, Schuh KJ, Barnes JM, Araujo AB. Atomoxetine monotherapy compared with combination therapy for the treatment of ADHD: a retrospective chart review study. Expert Rev Neurother. 2015 Oct 21:1-14. [Epub ahead of print] PubMed PMID: 26488905.

3: Fang Y, Ji N, Cao Q, Su Y, Chen M, Wang Y, Yang L. Variants of Dopamine Beta Hydroxylase Gene Moderate Atomoxetine Response in Children with Attention-Deficit/Hyperactivity Disorder. J Child Adolesc Psychopharmacol. 2015 Oct;25(8):625-32. doi: 10.1089/cap.2014.0178. Epub 2015 Oct 8. PubMed PMID: 26447643.

4: Chou TL, Chia S, Shang CY, Gau SS. Differential therapeutic effects of 12-week treatment of atomoxetine and methylphenidate on drug-naïve children with attention deficit/hyperactivity disorder: A counting Stroop functional MRI study. Eur Neuropsychopharmacol. 2015 Sep 8. pii: S0924-977X(15)00280-1. doi: 10.1016/j.euroneuro.2015.08.024. [Epub ahead of print] PubMed PMID: 26409297.

5: Hale GM, Brenner M. Atomoxetine for Orthostatic Hypotension in an Elderly Patient Over 10 Weeks: A Case Report. Pharmacotherapy. 2015 Sep;35(9):e141-8. doi: 10.1002/phar.1635. PubMed PMID: 26406777.

6: Lin HY, Gau SS. Atomoxetine Treatment Strengthens an Anti-Correlated Relationship between Functional Brain Networks in Medication-Naïve Adults with Attention-Deficit Hyperactivity Disorder: A Randomized Double-Blind Placebo-Controlled Clinical Trial. Int J Neuropsychopharmacol. 2015 Sep 16. pii: pyv094. doi: 10.1093/ijnp/pyv094. [Epub ahead of print] PubMed PMID: 26377368.

7: Perugi G, Vannucchi G. The use of stimulants and atomoxetine in adults with comorbid ADHD and bipolar disorder. Expert Opin Pharmacother. 2015 Oct;16(14):2193-204. doi: 10.1517/14656566.2015.1079620. PubMed PMID: 26364896.

8: Clemow DB, Bushe CJ. Atomoxetine in patients with ADHD: A clinical and pharmacological review of the onset, trajectory, duration of response and implications for patients. J Psychopharmacol. 2015 Sep 8. pii: 0269881115602489. [Epub ahead of print] Review. PubMed PMID: 26349559.

9: Stegmann B, Dörfelt A, Haen E. Quantification of Methylphenidate, Dexamphetamine and Atomoxetine in Human Serum and Oral Fluid by HPLC with Fluorescence Detection. Ther Drug Monit. 2015 Sep 2. [Epub ahead of print] PubMed PMID: 26349081.

10: Walker DJ, Mason O, Clemow DB, Day KA. Atomoxetine treatment in adults with attention-deficit/hyperactivity disorder. Postgrad Med. 2014 Sep;127(7):686-701. doi: 10.1080/00325481.2015.1081046. PubMed PMID: 26343377.

11: Yamada N, Kakuda W, Yamamoto K, Momosaki R, Abo M. Atomoxetine administration combined with intensive speech therapy for post-stroke aphasia: evaluation by a novel SPECT method. Int J Neurosci. 2015 Sep 3:1-10. [Epub ahead of print] PubMed PMID: 26335615.

12: Kabul S, Alatorre C, Montejano LB, Farr AM, Clemow DB. Real-World Dosing Patterns of Atomoxetine in Adults with Attention-Deficit/Hyperactivity Disorder. CNS Neurosci Ther. 2015 Aug 30. doi: 10.1111/cns.12442. [Epub ahead of print] PubMed PMID: 26331467.

13: Upadhyaya H, Tanaka Y, Lipsius S, Kryzhanovskaya LA, Lane JR, Escobar R, Trzepacz PT, Allen AJ. Time-to-onset and -resolution of adverse events before/after atomoxetine discontinuation in adult patients with ADHD. Postgrad Med. 2014 Sep;127(7):677-85. doi: 10.1080/00325481.2015.1083394. Epub 2015 Sep 2. PubMed PMID: 26329980.

14: Brown JT, Bishop JR. Atomoxetine pharmacogenetics: associations with pharmacokinetics, treatment response and tolerability. Pharmacogenomics. 2015 Aug;16(13):1513-20. doi: 10.2217/PGS.15.93. Epub 2015 Aug 28. PubMed PMID: 26314574.

15: Cortese S, Panei P, Arcieri R, Germinario EA, Capuano A, Margari L, Chiarotti F, Curatolo P. Safety of Methylphenidate and Atomoxetine in Children with Attention-Deficit/Hyperactivity Disorder (ADHD): Data from the Italian National ADHD Registry. CNS Drugs. 2015 Aug 21. [Epub ahead of print] PubMed PMID: 26293742.

16: Yamada N, Kakuda W, Yamamoto K, Momosaki R, Abo M. Atomoxetine administration combined with intensive speech therapy for post-stroke aphasia: Evaluation using a novel SPECT method. Int J Neurosci. 2015 Aug 13:1-28. [Epub ahead of print] PubMed PMID: 26268403.

17: Byeon JY, Kim YH, Na HS, Jang JH, Kim SH, Lee YJ, Bae JW, Kim IS, Jang CG, Chung MW, Lee SY. Effects of the CYP2D6*10 allele on the pharmacokinetics of atomoxetine and its metabolites. Arch Pharm Res. 2015 Aug 9. [Epub ahead of print] PubMed PMID: 26254792.

18: Ozbaran B, Kose S, Yuzuguldu O, Atar B, Aydin C. Combined methylphenidate and atomoxetine pharmacotherapy in attention deficit hyperactivity disorder. World J Biol Psychiatry. 2015 Jul 30:1-6. [Epub ahead of print] PubMed PMID: 26223958.

19: Shang CY, Pan YL, Lin HY, Huang LW, Gau SS. An Open-Label, Randomized Trial of Methylphenidate and Atomoxetine Treatment in Children with Attention-Deficit/Hyperactivity Disorder. J Child Adolesc Psychopharmacol. 2015 Sep;25(7):566-73. doi: 10.1089/cap.2015.0035. Epub 2015 Jul 29. PubMed PMID: 26222447.

20: Ince Tasdelen B, Karakaya E, Oztop DB. Effects of Atomoxetine and Osmotic Release Oral System-Methylphenidate on Executive Functions in Patients with Combined Type Attention-Deficit/Hyperactivity Disorder. J Child Adolesc Psychopharmacol. 2015 Aug;25(6):494-500. doi: 10.1089/cap.2014.0155. Epub 2015 Jul 28. PubMed PMID: 26218871.