RO8994
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 407194

CAS#: 1309684-94-3

Description: RO8994 is a potent and selective spiroindolinone MDM2 inhibitor, and potential useful for cancer therapy. At variance to solid tumors, which show percentage of p53 deletions and/or mutations close to 50%, more than 80% of haematological malignancies express wild-type p53 at diagnosis. Therefore, activation of the p53 pathway by antagonizing its negative regulator murine double minute 2 (MDM2) might offer a new therapeutic strategy for the great majority of haematological malignancies.


Chemical Structure

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RO8994
CAS# 1309684-94-3

Theoretical Analysis

MedKoo Cat#: 407194
Name: RO8994
CAS#: 1309684-94-3
Chemical Formula: C31H31Cl2FN4O4
Exact Mass: 612.17064
Molecular Weight: 613.51
Elemental Analysis: C, 60.69; H, 5.09; Cl, 11.56; F, 3.10; N, 9.13; O, 10.43

Size Price Shipping out time Quantity
10mg USD 150 Same day
25mg USD 250 Same day
50mg USD 450 Same day
100mg USD 650 Same day
200mg USD 1050 Same day
500mg USD 1850 Same day
1g USD 2950 Same day
2g USD 5450 2 Weeks
5g USD 7850 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2021-02-27. Prices are subject to change without notice.

RO8994, purity > 98%, is in stock.The same day shipping out after order is received.

Synonym: RO8994; RO-8994; RO 8994.

IUPAC/Chemical Name: (2'S,3R,4'R,5'R)-N-(4-carbamoyl-2-methoxyphenyl)-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-neopentyl-2-oxospiro[indoline-3,3'-pyrrolidine]-5'-carboxamide

InChi Key: MURAVORBGFDSMA-KTHXJTJTSA-N

InChi Code: InChI=1S/C31H31Cl2FN4O4/c1-30(2,3)14-23-31(18-10-9-16(32)13-21(18)37-29(31)41)24(17-6-5-7-19(33)25(17)34)26(38-23)28(40)36-20-11-8-15(27(35)39)12-22(20)42-4/h5-13,23-24,26,38H,14H2,1-4H3,(H2,35,39)(H,36,40)(H,37,41)/t23-,24+,26+,31+/m0/s1

SMILES Code: O=C([C@H](N[C@H]1CC(C)(C)C)[C@@H](C2=CC=CC(Cl)=C2F)[C@@]31C(NC4=C3C=CC(Cl)=C4)=O)NC5=CC=C(C(N)=O)C=C5OC

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 613.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Zhang Z, Ding Q, Liu JJ, Zhang J, Jiang N, Chu XJ, Bartkovitz D, Luk KC,
Janson C, Tovar C, Filipovic ZM, Higgins B, Glenn K, Packman K, Vassilev LT,
Graves B. Discovery of potent and selective spiroindolinone MDM2 inhibitor,
RO8994, for cancer therapy. Bioorg Med Chem. 2014 Aug 1;22(15):4001-9. doi:
10.1016/j.bmc.2014.05.072. Epub 2014 Jun 11. PubMed PMID: 24997575.