WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 317250

CAS#: 71963-77-4

Description: Artemether is a natural product which effectively kills both malarial parasites P. falciparum and P. vivax. Artemether is usually used in combination with Lumefantrine for the treatment of malaria. Arthemether also kills trematodes of the species Schistosoma, providing protection against schistosomiasis. Sesquiterpene lactones like artemether, artesunate, and artemisinin have potential applications in certain types of cancer and inflammatory conditions.

Chemical Structure

CAS# 71963-77-4

Theoretical Analysis

MedKoo Cat#: 317250
Name: Artemether
CAS#: 71963-77-4
Chemical Formula: C16H26O5
Exact Mass: 298.17802
Molecular Weight: 298.37
Elemental Analysis: C, 64.41; H, 8.78; O, 26.81

Price and Availability

Size Price Availability Quantity
5.0mg USD 48.0 2 Weeks
10.0mg USD 50.0 2 Weeks
25.0mg USD 60.0 2 Weeks
50.0mg USD 70.0 2 Weeks
100.0mg USD 80.0 2 Weeks
200.0mg USD 90.0 2 Weeks
500.0mg USD 110.0 2 Weeks
1.0g USD 120.0 2 Weeks
2.0g USD 150.0 2 Weeks
5.0g USD 250.0 2 Weeks
10.0g USD 450.0 2 Weeks
20.0g USD 650.0 2 Weeks
50.0g USD 850.0 2 Weeks
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Synonym: Artemos; Artenam; Artesaph; Artesian; Dihydroartemisinin Methyl Ether; Falcidol; Gvither; Larither; Malartem; SM 224; β-Artemether; β-Dihydroartemisinin Methyl Ether

IUPAC/Chemical Name: (3R,5aS,6R,8aS,9R,10S,12R,12aR)-decahydro-10-methoxy-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin


InChi Code: InChI=1S/C16H26O5/c1-9-5-6-12-10(2)13(17-4)18-14-16(12)11(9)7-8-15(3,19-14)20-21-16/h9-14H,5-8H2,1-4H3/t9-,10-,11+,12+,13+,14-,15-,16-/m1/s1

SMILES Code: C[C@@H]1CC[C@H]2[C@H]([C@H](O[C@H]3[C@@]24[C@H]1CC[C@](O3)(OO4)C)OC)C

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 298.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Swain TR, Raulo A, Mohapatra N, Singha MR. Information Education and
Communication can Improve Adherence to Artemether-Lumefantrine Combination in
Patients of Uncomplicated Falciparum Malaria. J Clin Diagn Res. 2015
Sep;9(9):FC01-3. doi: 10.7860/JCDR/2015/13196.6544. Epub 2015 Sep 1. PubMed PMID:

2: Parikh S, Fehintola F, Huang L, Olson A, Adedeji WA, Darin KM, Morse GD,
Murphy RL, Taiwo BO, Akinyinka OO, Adewole IF, Aweeka FT, Scarsi KK.
Artemether-lumefantrine exposure in HIV-infected Nigerian subjects on
nevirapine-containing antiretroviral therapy. Antimicrob Agents Chemother. 2015
Sep 21. pii: AAC.01153-15. [Epub ahead of print] PubMed PMID: 26392500.

3: WorldWide Antimalarial Resistance Network (WWARN) Lumefantrine PK/PD Study
Group. Artemether-lumefantrine treatment of uncomplicated Plasmodium falciparum
malaria: a systematic review and meta-analysis of day 7 lumefantrine
concentrations and therapeutic response using individual patient data. BMC Med.
2015 Sep 18;13(1):227. doi: 10.1186/s12916-015-0456-7. PubMed PMID: 26381375;
PubMed Central PMCID: PMC4574542.

4: Gray AM, Arguin PM, Hamed K. Surveillance for the safety and effectiveness of
artemether-lumefantrine in patients with uncomplicated Plasmodium falciparum
malaria in the USA: a descriptive analysis. Malar J. 2015 Sep 17;14:349. doi:
10.1186/s12936-015-0881-2. PubMed PMID: 26377423; PubMed Central PMCID:

5: Yavo W, Konaté A, Kassi FK, Djohan V, Angora EK, Kiki-Barro PC, Vanga-Bosson
H, Menan EI. Efficacy and Safety of Artesunate-Amodiaquine versus
Artemether-Lumefantrine in the Treatment of Uncomplicated Plasmodium falciparum
Malaria in Sentinel Sites across Côte d'Ivoire. Malar Res Treat.
2015;2015:878132. doi: 10.1155/2015/878132. Epub 2015 Aug 12. PubMed PMID:
26347849; PubMed Central PMCID: PMC4549615.

6: Bendel D, Rulisa S, Ansah P, Sirima S. Efficacy of a Novel Sublingual Spray
Formulation of Artemether in African Children with Plasmodium falciparum Malaria.
Antimicrob Agents Chemother. 2015 Nov;59(11):6930-8. doi: 10.1128/AAC.00243-15.
Epub 2015 Aug 24. PubMed PMID: 26303805.

7: Sondo P, Derra K, Diallo-Nakanabo S, Tarnagda Z, Zampa O, Kazienga A, Valea I,
Sorgho H, Owusu-Dabo E, Ouedraogo JB, Guiguemde TR, Tinto H. Effectiveness and
safety of artemether-lumefantrine versus artesunate-amodiaquine for unsupervised
treatment of uncomplicated falciparum malaria in patients of all age groups in
Nanoro, Burkina Faso: a randomized open label trial. Malar J. 2015 Aug 20;14:325.
doi: 10.1186/s12936-015-0843-8. PubMed PMID: 26289949; PubMed Central PMCID:

8: Mekonnen SK, Medhin G, Berhe N, Clouse RM, Aseffa A. Efficacy of
artemether-lumefantrine therapy for the treatment of uncomplicated Plasmodium
falciparum malaria in Southwestern Ethiopia. Malar J. 2015 Aug 15;14:317. doi:
10.1186/s12936-015-0826-9. PubMed PMID: 26271736; PubMed Central PMCID:

9: Pfeil J, Borrmann S, Bassat Q, Mulenga M, Talisuna A, Tozan Y. An Economic
Evaluation of the Posttreatment Prophylactic Effect of
Dihydroartemisinin-Piperaquine Versus Artemether-Lumefantrine for First-Line
Treatment of Plasmodium falciparum Malaria Across Different Transmission Settings
in Africa. Am J Trop Med Hyg. 2015 Aug 3. pii: 15-0162. [Epub ahead of print]
PubMed PMID: 26240155.

10: Achieng AO, Muiruri P, Ingasia LA, Opot BH, Juma DW, Yeda R, Ngalah BS, Ogutu
BR, Andagalu B, Akala HM, Kamau E. Temporal trends in prevalence of Plasmodium
falciparum molecular markers selected for by artemether-lumefantrine treatment in
pre-ACT and post-ACT parasites in western Kenya. Int J Parasitol Drugs Drug
Resist. 2015 Jun 29;5(3):92-9. doi: 10.1016/j.ijpddr.2015.05.005. eCollection
2015 Dec. PubMed PMID: 26236581; PubMed Central PMCID: PMC4501530.

11: Wu J, Li H, Li M. Effects of artemether on the proliferation, apoptosis, and
differentiation of keratinocytes: potential application for psoriasis treatment.
Int J Clin Exp Med. 2015 May 15;8(5):7069-78. eCollection 2015. PubMed PMID:
26221244; PubMed Central PMCID: PMC4509189.

12: Ukah M, Badejoko O, Ogunniyi S, Loto O, Aboderin O, Fatusi A. A randomized
trial of artesunate-amodiaquine versus artemether-lumefantrine for the treatment
of acute uncomplicated malaria in pregnancy. Int J Gynaecol Obstet. 2015
Oct;131(1):41-4. doi: 10.1016/j.ijgo.2015.05.009. Epub 2015 Jul 3. PubMed PMID:

13: Wasunna B, Okiro EA, Webster J, Todd J, Snow RW, Jones C. The Impact of a
Community Awareness Strategy on Caregiver Treatment Seeking Behaviour and Use of
Artemether-Lumefantrine for Febrile Children in Rural Kenya. PLoS One. 2015 Jul
2;10(7):e0130305. doi: 10.1371/journal.pone.0130305. eCollection 2015. PubMed
PMID: 26135143; PubMed Central PMCID: PMC4489881.

14: Getnet G, Fola AA, Alemu A, Getie S, Fuehrer HP, Noedl H. Therapeutic
efficacy of artemether-lumefantrine for the treatment of uncomplicated Plasmodium
falciparum malaria in Enfranze, north-west Ethiopia. Malar J. 2015 Jun 24;14:258.
doi: 10.1186/s12936-015-0775-3. PubMed PMID: 26105035; PubMed Central PMCID:

15: Ansari MT, Hussain A, Nadeem S, Majeed H, Saeed-Ul-Hassan S, Tariq I, Mahmood
Q, Khan AK, Murtaza G. Preparation and Characterization of Solid Dispersions of
Artemether by Freeze-Dried Method. Biomed Res Int. 2015;2015:109563. doi:
10.1155/2015/109563. Epub 2015 May 17. PubMed PMID: 26097842; PubMed Central
PMCID: PMC4449868.

16: O'Neill JF, Johnston RC, Halferty L, Hanna RE, Brennan GP, Fairweather I. A
comparative study on the impact of two artemisinin derivatives, artemether and
artesunate, on the female reproductive system of Fasciola hepatica. Vet
Parasitol. 2015 Jul 30;211(3-4):182-94. doi: 10.1016/j.vetpar.2015.05.027. Epub
2015 Jun 6. PubMed PMID: 26093822.

17: Yalçın M, Sevim E, Duran A. [Treated with Artemether-Lumefantrine Five
Evaluation of P. Falciparum Malaria Cases in Terms of Hyponatremia and
Thrombocytopenia]. Turkiye Parazitol Derg. 2015 Jun;39(2):155-8. doi:
10.5152/tpd.2015.3520. Turkish. PubMed PMID: 26081891.

18: Djimde AA, Makanga M, Kuhen K, Hamed K. The emerging threat of artemisinin
resistance in malaria: focus on artemether-lumefantrine. Expert Rev Anti Infect
Ther. 2015 Aug;13(8):1031-45. doi: 10.1586/14787210.2015.1052793. Epub 2015 Jun
16. PubMed PMID: 26081265.

19: Denoeud-Ndam L, Dicko A, Baudin E, Guindo O, Grandesso F, Sagara I, Lasry E,
Palma PP, Parra AM, Stepniewska K, Djimde AA, Barnes KI, Doumbo OK, Etard JF. A
multi-center, open-label trial to compare the efficacy and pharmacokinetics of
Artemether-Lumefantrine in children with severe acute malnutrition versus
children without severe acute malnutrition: study protocol for the MAL-NUT study.
BMC Infect Dis. 2015 Jun 12;15:228. doi: 10.1186/s12879-015-0963-3. PubMed PMID:
26068100; PubMed Central PMCID: PMC4464227.

20: Ebstie YA, Zeynudin A, Belachew T, Desalegn Z, Suleman S. Assessment of
therapeutic efficacy and safety of artemether-lumefantrine (Coartem®) in the
treatment of uncomplicated Plasmodium falciparum malaria patients in Bahir Dar
district, Northwest Ethiopia: an observational cohort study. Malar J. 2015 Jun
5;14:236. doi: 10.1186/s12936-015-0744-x. PubMed PMID: 26045199; PubMed Central
PMCID: PMC4464854.